دوره 19، شماره 76 - ( 3-1390 )                   جلد 19 شماره 76 صفحات 17-11 | برگشت به فهرست نسخه ها

XML English Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Karimi M, Divani Shishvan F, Mousavinasab S N. A Comparison of Serum Homocysteine, Folate and Vitamin B12 in Postmenopausal Women with Low and Normal Bone Mineral Density. J Adv Med Biomed Res 2011; 19 (76) :11-17
URL: http://journal.zums.ac.ir/article-1-1566-fa.html
کریمی مرجانه، دیوانی شیشوان فرشید، موسوی نسب سید نورالدین. مقـایسه‌ی سطح خونی هوموسیستئین، فولات و ویتامین B12 در خانم‌های یـائسه با دانسیته استخوانی پایین و نرمال. Journal of Advances in Medical and Biomedical Research. 1390; 19 (76) :11-17

URL: http://journal.zums.ac.ir/article-1-1566-fa.html

مقـایسه‌ی سطح خونی هوموسیستئین، فولات و ویتامین B12 در خانم‌های یـائسه با دانسیته استخوانی پایین و نرمال
مرجانه کریمی*1 ، فرشید دیوانی شیشوان ، سید نورالدین موسوی نسب2
1- متخصص داخلی و فوق تخصص روماتولوژی، استادیار دانشگاه علوم پزشکی زنجان، مرکز تحقیقات بیماری‌های متابولیک ، mrj_karimi@yahoo.com
2- دکترای آمار حیاتی، دانشیار دانشگاه علوم پزشکی زنجان
چکیده:   (166416 مشاهده)

Background and Objective: Osteoporotic fractures are major health problems in contemporary societies which are associated with increased morbidity and mortality and substantial economic costs. Recently, increased plasma homocysteine (Hcy) level has been suggested as an independent risk factor for osteoporotic fractures. This study aimed to compare the level of plasma homocysteine, folate and vitamin B12 in Iranian postmenopausal women with low and normal bone mineral density (BMD).
Materials and Methods: In this case-control study which was performed from August 2006 to May 2007, BMD of 130 Iranian postmenopausal women were measured by dual energy X- ray absorbtiometry (DXA). The subjects were assigned to one of the two groups of case (BMD < -1; n= 67) and control (BMD ≥ -1; n=63). Fasting plasma Homocysteine, folate and vitamin B12 were also determined. BMD at the neck of femur and lumbar spine, together with other collected data were analyzed with SPSS and T- test.
Results: The mean age of the subjects was 58.1 ± 6 years. The mean of Hcy level in the case group was 16.98±9.4 and in the control group was 12.39(p=0.002 M mol/L). The mean of vit-B12 in the case group was
598± 801 and in the control group was 551.2±410 (p=0.007 Pg/L). Mann-Whitney test exibited a significant difference. The mean of serum folate level in the case group was 5.2±2.9 and in the control group was 6.5±2.9 (p=0.017 Ng/L). Hcy, folate and B12 were significantly related to low BMD. LS –T score was negatively related to Hcy level and FN T-score had a positive relation with folate and B12 (p=0.002, p=0.017 and p=0.007, respectively). There was a relationship between folate and B12 and with increasing serm folate level, B12 level increased, too.
Conclusion: The results suggest an association of vitamin B12 and folate with BMD. Whether this relationship is causal, remains unclear and demands further study.

متن کامل [PDF 210 kb]   (162496 دریافت)    
نوع مطالعه: مقاله پژوهشی |
دریافت: 1390/6/2 | پذیرش: 1393/4/1 | انتشار: 1393/4/1
فهرست منابع
1. Martin Tj, Sim NK. Regulatory pathways reveal new approaches to the development of anabolic drugs for osteoporosis. Osteoporosis Int. 2008; 19: 1139-45. [DOI:10.1007/s00198-008-0575-5] [PMID]
2. Refsum H, Veland PM. Homocysteine and cardio vascular dis. Annu Rev med. 1998; 49: 31-62. [DOI:10.1146/annurev.med.49.1.31] [PMID]
3. Clarke R, Smith AD. Folate, Vit-B12, and serum total homocysteine levels in confirmed alzheimer disease. Arch Neurol.1998; 11: 1449-55. [DOI:10.1001/archneur.55.11.1449] [PMID]
4. Lubec B, Fang-kircher S. Evidence for MC kusick's hypothesis of deficient collagen cross-linking in patients with Homocystinuria. Biochim Biophys Acta. 1996; 1315: 159-62. [DOI:10.1016/0925-4439(95)00119-0]
5. Saito M, Fuji K, Degree of mineralization-related collagen cross linking in the femoral neck cancellous bone in cases of hip fracture and controls. Calcifi Tissue Int. 2006; 79: 160-8. [DOI:10.1007/s00223-006-0035-1] [PMID]
6. Krumdieck CL, prince CW. Mechanisms of homocysteine toxicity on connective tissue implications for morbidity of aging. J Nutr. 2000; 130: 3655-83. [DOI:10.1093/jn/130.2.365S] [PMID]
7. Mclean RR, Jacques PF. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med. 2004; 350: 2042-9. [DOI:10.1056/NEJMoa032739] [PMID]
8. LeBoff MS, Narweker R, Lacroix A, et al. Homocysteine levels and risk of hip fracture in postmenopausal women. J Clin Endocrinol Metab. 2009; 94: 1207-13. [DOI:10.1210/jc.2008-1777] [PMID] [PMCID]
9. Mudd SH, Skouby F. The natural history of homocystinuria due to cystathionine beta-synthase deficiency. Am J Hum Genet. 1985; 37: 1-31.
10. Golbahar J, Hamidi A, Aminzadeh MA. Association of plasma folate, plasma total homocysteine but not methylen tetrahydrofolate reductase C6677 polymorphism with BMD in postmenopausal. Iranian woman: a cross sectional study. Bone. 2004; 35: 760-5. [DOI:10.1016/j.bone.2004.04.018] [PMID]
11. Morris MS, Jacques PF. Relation between Hcy and B- vitamins statues indicators and BMD in older Americans. Bone. 2005; 37: 234-42. [DOI:10.1016/j.bone.2005.04.017] [PMID]
12. Rassmussen LB, Ovesen L, Bulow I, et al. Folate intake lifestyle factors, and homocysteine concentrations in younger and older woman. Am J clin Nut. 2000; 72: 1156-63. [DOI:10.1093/ajcn/72.5.1156] [PMID]
13. Das UN. Folic acid says no to vascular disease. Nutrition. 2003; 19: 686-92. [DOI:10.1016/S0899-9007(02)01044-4]
14. Stone KL, Baner DC. Low serum vit- B12 levels are associated with increased hip bone loss in older women: a prospective study. J Clin Endocrinol Metab. 2004; 89: 1214-21. [DOI:10.1210/jc.2003-030074] [PMID]
15. Dhonukshe-Rutten RA, Lips M. Vit - B12 status is associated with bone mineral content and BMD in frail elderly women but not in men. JNut. 2003; 133: 801-7 [DOI:10.1093/jn/133.3.801] [PMID]
16. Tucker KL, Hannan MT. Low plasma Vit- B12 associated with lower BMD: The Framingham osteoporosis study. J Bone Miner Res. 2005; 20: 152-8. [DOI:10.1359/jbmr.2005.20.1.152]
17. Cagnacci A, Baldassari F. Relation of homocysteine, folate and B12 to BMD of postmenopausal women. Bone. 2003; 33: 956-9. [DOI:10.1016/j.bone.2003.07.001] [PMID]
18. Sato Y, Honda Y. Effect of folate and metcobalamin on hip fractures in patients with stroke: a randomized controlled trial. JAMA. 2005; 293: 1082-8. [DOI:10.1001/jama.293.9.1082] [PMID]
19. McLean RR, JacquesPF, Selhub J, et al. Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women. J Clin Endocrinol Metab. 2008; 93: 2206-12. [DOI:10.1210/jc.2007-2710] [PMID] [PMCID]
20. Van Meurs JB. Homocysteine levels and the risk of osteoporotic fractures. N Eng J Med. 2004; 35: 2033-41. [DOI:10.1056/NEJMoa032546] [PMID]
21. Sato Y, Honda Y. Homocysteine as a predictive factor for hip fracture in stroke patients. Bone. 2005; 36: 721-6. [DOI:10.1016/j.bone.2005.01.011] [PMID]
22. Cagnocci A, Bagni B, Relation of folate, vit- B12 and homocystein to vertebral BMD change in postmenopausal women. A five- year longitudinal evaluation. Bone. 2008; 42: 314-20. [DOI:10.1016/j.bone.2007.10.022] [PMID]
23. Koh JM, Lee YS. Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation. J Bone Miner Res. 2006; 21: 1003-11. [DOI:10.1359/jbmr.060406] [PMID]
24. Khan M, Yamaguchi M. Homocysteine decreases chondrocyte mediated matrix mineralization in differentiating chick limb-bud mesenchymal cells micromass cultures. Bone. 2001; 28: 387-98. [DOI:10.1016/S8756-3282(01)00409-4]
25. Morris MS, Relation between homocysteine and vit - B12 status indicators and BMD in older Americans. Bone. 2005; 37: 234-42. [DOI:10.1016/j.bone.2005.04.017] [PMID]
26. Melton ME, Kochman ML. Reversal of severe osteoporosis with vit - B12 and etidronate therapy in a patient with pernicious Anemia. Metabolism. 1994; 43: 468-9. [DOI:10.1016/0026-0495(94)90078-7]
ارسال پیام به نویسنده مسئول

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به Journal of Advances in Medical and Biomedical Research می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2025 CC BY-NC 4.0 | Journal of Advances in Medical and Biomedical Research

Designed & Developed by : Yektaweb