دوره 26، شماره 116 - ( 5-1397 )                   جلد 26 شماره 116 صفحات 121-111 | برگشت به فهرست نسخه ها

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Mirazi N, Norbar E, Soleymani M. Effect of Hydroethanolic Echinophora platyloba L. Extract on Testosterone and Gonadotropin Serum Levels in Carbon Tetrachloride-Induced Male Rats. J Adv Med Biomed Res 2018; 26 (116) :111-121
URL: http://journal.zums.ac.ir/article-1-5093-fa.html
میرازی ناصر، نوربار الهام، سلیمانی مریم. بررسی اثر عصاره هیدروالکلی گیاه خوشاریزه (Echinophora platyloba L.) بر غلظت سرمی تستوسترون و گنادوتروپین‌ها در موش صحرایی نر القا شده با تتراکلرید کربن. Journal of Advances in Medical and Biomedical Research. 1397; 26 (116) :111-121

URL: http://journal.zums.ac.ir/article-1-5093-fa.html

بررسی اثر عصاره هیدروالکلی گیاه خوشاریزه (Echinophora platyloba L.) بر غلظت سرمی تستوسترون و گنادوتروپین‌ها در موش صحرایی نر القا شده با تتراکلرید کربن
ناصر میرازی* 1، الهام نوربار2 ، مریم سلیمانی2
1- دکترای تخصصی فیزیولوژی، دانشیار گروه زیست شناسی، دانشکده‌ی علوم پایه، دانشگاه بوعلی سینا، همدان ، Mirazi205@gmail.com
2- کارشناس ارشد فیزیولوژی، گروه زیست شناسی، دانشکده‌ی علوم پایه، دانشگاه بوعلی سینا، همدان
چکیده:   (154641 مشاهده)

Background and Objective: Carbon tetrachloride is one of the chemical toxins widely used in hygiene industries. The aim of this study was to investigate the effects of Echinophora platyloba extract (EPE) on serum levels of testosterone and gonadotropins in male rats induced with carbon tetrachloride.
Materials and Methods: In this experimental study 49  male Wistar  rats (220-250 g) were randomly divided into seven groups (n=7): Control group (2 ml/kg  normal saline, daily for 4 days, ip), toxicant group (2 ml/kg CCl4+olive oil.1:1, single dose ,ip), sham group (2 ml/kg  olive oil, single dose, ip), positive control group (400 mg/kg EPE daily for 4 days, ip), toxicant-treated groups 1, 2 and 3 (CCl4+ olive oil.1:1, single dose and 200 and 400 and 800 mg/kg of EPE, respectively, daily for 4 days, ip). At the end of the treatments, serum testosterone and FSH & LH hormones were measured.
Results: CCL4 resulted in significantly decreased testosterone and increased FSH & LH serum levels in the toxicant group compared with the control group (P<0.001). EPE treatment with 400 and 800 mg/kg resulted in a significant increase in testosterone and decrease in FSH & LH serum levels compared with the toxicant group (P<0.001).   
Conclusion: Hydro-ethanolic E. platyloba extract increased serum levels of testosterone and decreased FSH and LH serum levels in male rats induced with CCL4.

متن کامل [PDF 3323 kb]   (156926 دریافت)    
نوع مطالعه: کارآزمایی بالینی |
دریافت: 1396/12/12 | پذیرش: 1396/12/12 | انتشار: 1396/12/12
فهرست منابع
1. Pourahmadi M , Bagheri M, Karimi Jashni H , Kargar Jahromi H, Zarei S. The effect of hydroalkoholic extract urtica dioica on concentrations of sex hormones in adult male rats. J Jahrom Univ Med Sci. 2013; 10: 29-34. [DOI:10.29252/jmj.10.4.29]
2. Mokhtari M, Abedinzade M, Naseran N. Effect of walnut (Juglans regia) extract on serum LH, FSH and testosterone levels in adult male rat. J Ardabil Univ Med Sci. 2011; 12: 157-165.
3. Soleimani Z, Mirazi N. Study of Avicennia marina hydroethanolic extract effects on spermatogenesis in male rats induced with carbon trtrachloride. Armaghane-Danesh. 2015; 20:677-88.
4. Saber, saker and Hawazen A, Lamfon. Protective effect of rosemary leaves extract on carbone tetrachloride induced nephrotoxicity in albino rats. Life Sci J. 2012; 9: 779-85.
5. El-mohsen A, Abdelaziz SA. The protective effect of date seeds on nephrotoxicity in rats. Int J Pharmaceutic Sci. 2014; 26: 62-68.
6. Sonmez M, Turk G, Ceribasi S, et al. Quercetin attenuates carbon tetrachloride-induced testicular damage in rats. aNDROLOGIa. 2014; 46: 848-58. [DOI:10.1111/and.12159] [PMID]
7. Sikka SC. Oxidative stress and role of antioxidants in normal and abnormal sperm function. Front Biosci. 1996; 1: e78-86. [DOI:10.2741/A146]
8. Aitken RJ, Clarkson JS. Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. J Reprod Fertil. 1987; 81: 459-69. [DOI:10.1530/jrf.0.0810459] [PMID]
9. Sadat Sadr M, Najafian M, Zareian M, Kargar H. Effect of broccoli (Brassica Oleracea) hydro-alcoholic extract on concentration of LH, FSH and Testosterone hormones in male adult rats. Jentashapir. 2013; 4: 101-10.
10. Mirghazanfari SM, Hosseinzadeh L, Shokoohinia Y, Aslany M, Kamali-Nejad M. Acute and subchronic toxicological evaluation of Echinophora platyloba DC (Apiaceae) total extract in wistar rats. Clinics (Sao Paulo). 2012; 67: 497-502. [DOI:10.6061/clinics/2012(05)15]
11. Delaram M, Kheiri S, Hodjati M. Comparing the effects of Echinophora-platyloba, fennel and placebo on pre-menstrual syndrome. J Reprod Infertil. 2011; 12: 221-226.
12. Pass M, Rashidipour M, Talei Gh, Doosty B. Chemical compositions, antibacterial and antioxidant properties of Echinophora cinerea essential oil. J Herbal Drug. 2012; 3: 67-74.
13. Zarali M, Hojjati M, Tahmouzi Didehban S, Jooinadeh H. Evaluation of chemical composition and antibacterial activities of Echinophora cinerea Boiss and Stachys lavandulifolia Vahl essential oils in vitro. JFST. 2016; 52: 1-10.
14. Aqababa H ,Golkary H , Zarei A , Changizi-Ashtiyani S. Effect of aerial parts extract of Echinophora Platyloba.L on liver and kidney function tests in obese hypercholesterolaemia rats. J Shahid Sadoughi Univ Med Sci. 2016; 23:943-56.
15. Heidarian E, Saffari J, Jafari-Dehkordi E. Hepatoprotective action of Echinophora platyloba DC leaves against acute toxicity of acetaminophen in rats. J Dietary Sup. 2014; 11: 53-63. [DOI:10.3109/19390211.2013.859217] [PMID]
16. Mirchenari M, Mokhtari M, Shariati M. The effect of hydroalcoholic extract of salvia officinalis on gonadotropin, and sex steroids in adult diabetic male rat. J Shahid Sadoughi Univ Med Sci. 2016; 23: 1018-27.
17. Grzegorczyk I, Matkowski A, Wysokinska H. Antioxidant activity of extracts from in vitro cultures of Salvia officinalis L. Food Chem. 2007; 104: 536-41. [DOI:10.1016/j.foodchem.2006.12.003]
18. Weber LW, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes carbon tertrachloride as toxicological model. Crit Rev Toxical. 2003; 33: 50-114. [DOI:10.1080/713611034] [PMID]
19. Hosseini SE, Jahandidea A, Mehrabani D. Effect of alcoholic extract of ginger during fetal life and breastfeeding on serum level of testosterone, LH, FSH and spermatogenic cells line in male mature offspring rats. J Gorgan Uni Med Sci. 2015; 17: 29-35.
20. Eidi A ,Olamfar S, Zaringhalam J, Rezazadeh S, Eidi M. Protective effect of walnut (Juglans regia L.) extract against ccl4 -induced hepatotoxicity in Rats. Res Med. 2011; 35: 87-92.
21. Ogbunugafor HA, Eneh FU, Ozumba AN, et al. Physico-chemical and anti-oxidant properties of Moringa oleifera seed oil. Pak J Nutr. 2011; 10: 409-14. [DOI:10.3923/pjn.2011.409.414]
22. Khaki A, Fathiazad F, Nouri M, et al. Anti-oxidative effect of citro flavonoids on spermatogenesis in rat. African J Pharmacy Pharmacol. 2011; 5: 721-25. [DOI:10.5897/AJPP11.277]
23. Ahmadi R, Balali S, Tavakoli P, Mafi M, Haji GR. The effect of hydroalcoholic leaf extract of Salvia Officinalis on serum levels of FSH, LH, testosterone and testicular tissue in rats. (FEYZ). 2013; 17: 225-31.
24. Souri E, Amin G, Farsma H, Barazandeh M. Screening of antioxidant activity and phenolic content of 24 medicinal plant extracts. DARU. 2008; 16: 83-87.
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