دوشنبه 28 اردیبهشت 1405
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دوره 34، شماره 1 - ( 11-1404 )
جلد 34 شماره 1 صفحات 22-15 |
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Kadhim A R, Aowda S A, Kareem M M. Synthesis, Characterization and Antimicrobial Evaluation of Polyacrylic acid Drug Conjugates Using Benzidine as a Spacer. J Adv Med Biomed Res 2026; 34 (1) :15-22
URL: http://journal.zums.ac.ir/article-1-7926-fa.html
URL: http://journal.zums.ac.ir/article-1-7926-fa.html
Synthesis, Characterization and Antimicrobial Evaluation of Polyacrylic acid Drug Conjugates Using Benzidine as a Spacer. Journal of Advances in Medical and Biomedical Research. 1404; 34 (1) :15-22
چکیده: (56 مشاهده)
Background & Objective: Polyacrylic acid can serve as an effective drug-delivery platform when conjugated with pharmaceutical compounds via a reliable spacer. This study aimed to synthesize and characterize benzidine-linked polyacrylic acid drug conjugates and evaluate their antimicrobial activity.
Materials & Methods: Conjugates were prepared by reacting polyacrylic acid with benzidine, followed by attachment of carboxylic-acid-containing drugs. The resulting polymers were characterized for structural and physicochemical properties. Antibacterial activity against Staphylococcus aureus and Escherichia coli was assessed.
Results: FTIR and ¹HNMR confirmed successful conjugation. Polymers showed pH-dependent drug-release behavior and varying molecular weights. AB1 and AB6 exhibited strong inhibition against S. aureus (20 and 18 mm) and moderate activity against E. coli, while AB2 demonstrated the highest effect against E. coli (28 mm). Most conjugates displayed enhanced antibacterial activity compared to the free drugs.
Conclusion: Spacer-mediated polyacrylic acid drug conjugates effectively modulate drug release and enhance antibacterial performance, highlighting their potential as controlled drug-delivery systems.
نوع مطالعه: مقاله پژوهشی |
موضوع مقاله:
Life Science
دریافت: 1404/9/12 | پذیرش: 1404/11/19 | انتشار: 1404/12/9
دریافت: 1404/9/12 | پذیرش: 1404/11/19 | انتشار: 1404/12/9
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