Backgrounds and Objective: The main important factors in decreasing cognitive performance are aging, proinflammatory and metabolic syndrome. The aim of this research was investigation the effect of twelve week aerobic exercise whit moderate intensity on IL-6, IL-10, and cognitive performance in 50-65 years old women with syndrome metabolic.

Materials and Methods: 24 women with metabolic syndrome (MetS) voluntarily took part in the study and were divided into two groups: MetS exercise (ME), MetS control (MC). The ME group participated in an aerobic exercise training (AT) program (12 weeks), three sessions per week, each session containing three performance parts and two rest parts. Also blood samples were drawn before and after training to evaluate levels of IL-6, IL-10. Cognitive performance was measured by digit span memory test. Data were analyzed using Pearson coefficient, pried-sample T-Test, and independent samples T-Test.

Results: After three months of aerobic exercise, IL-6 levels decrease while IL-10 levels and cognitive performance increased significantly (P<0.05). IL-6, IL-10, and cognitive performance in the control group were not altered after three months (P<0.05).

Conclusion: These findings indicate that three months of aerobic exercise can increase IL-10 level and decrease IL-6 while ameliorating cognitive performance.