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Volume 25, Issue 113 (8-2017)
J Adv Med Biomed Res 2017, 25(113): 113-121 |
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Mohebbi S, Hassan M, Gorji E. Preparation and Evaluation of Antibacterial and Antifungal Effects of Novel Isatin and Indole Derivatives Bearing a Hydantoin Moiety. J Adv Med Biomed Res 2017; 25 (113) :113-121
URL: http://journal.zums.ac.ir/article-1-4802-en.html
URL: http://journal.zums.ac.ir/article-1-4802-en.html
1- Dept. of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
2- Dept. of Food and Drug Control, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
2- Dept. of Food and Drug Control, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
Abstract: (150220 Views)
Background and Objective: Bacterial infections are an important and growing problem across the world. During the last few decades, the inappropriate consumption of antibiotics has led to increased antimicrobial resistance. A survey of literature demonstrates that isatin and indole rings are among the most favorable compounds with a potential for antimicrobial activity. Therefore in this study some novel isatin and indole derivatives coupled with hydantoin moiety were synthesized using a hybridization approach in order to evaluate the relationship between structure and antibacterial/antifungal activity.
Materials and Methods: The derivatives were prepared in good yields and their structures were confirmed using H-NMR, IR, and Mass Spectrometry. The antibacterial/antifungal activity of compounds was evaluated using the Broth Microdilution method on a series of gram positive and gram negative bacterial strains and Aspergillus niger.
Results: Among the tested compounds, the indole derivative #5 exhibited the highest activity against Pseudomonas aeruginosa with a MIC value of 31.25 µg/mL.
Conclusion[vog1] : These synthesized derivatives showed effective antibacterial activity mainly against Pseudomonas aeruginosa. On the other hand the tested compounds had appropriate spectrum effect ,because they showed antibacterial effect on both positive and negative strains.
Materials and Methods: The derivatives were prepared in good yields and their structures were confirmed using H-NMR, IR, and Mass Spectrometry. The antibacterial/antifungal activity of compounds was evaluated using the Broth Microdilution method on a series of gram positive and gram negative bacterial strains and Aspergillus niger.
Results: Among the tested compounds, the indole derivative #5 exhibited the highest activity against Pseudomonas aeruginosa with a MIC value of 31.25 µg/mL.
Conclusion[vog1] : These synthesized derivatives showed effective antibacterial activity mainly against Pseudomonas aeruginosa. On the other hand the tested compounds had appropriate spectrum effect ,because they showed antibacterial effect on both positive and negative strains.
[vog1] the English conclusion s the hould be written as Persian conclusion.
Type of Study: Clinical Trials |
Received: 2017/08/27 | Accepted: 2017/08/27 | Published: 2017/08/27
Received: 2017/08/27 | Accepted: 2017/08/27 | Published: 2017/08/27
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