Volume 30, Issue 140 (May & June 2022)                   J Adv Med Biomed Res 2022, 30(140): 211-214 | Back to browse issues page


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Allahverdi-Khani M, Ulloa L, Motaghinejad M, Salehirad M. Standardized Herbal PM014 Formula Ameliorates Pulmonary Fibrosis in COVID-19 Patients by Inhibiting the TGF-β1 Signaling Pathway. J Adv Med Biomed Res 2022; 30 (140) :211-214
URL: http://journal.zums.ac.ir/article-1-6453-en.html
1- Clinical Research Development Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran
2- Dept. of Anesthesiology, Center for Perioperative Organ Protection, Duke University, Durham, NC, USA
3- Chronic Respiratory Disease Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran , dr.motaghinejad6@gmail.com
4- Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Abstract:   (83659 Views)

A number of studies have previously provided evidence on the Anti-inflammatory properties of plant-derived compounds that can prevent lung injury. In this study, we attempted to analyze the therapeutic effects of PM 014 on inflammation and pulmonary fibrosis in COVID-19 as well as describing the treatment of one of the most challenging problems related to the coronavirus-19 (COVID-19). We believe that having a close look at all angles of the proposed mechanism goes beyond the physiological consequences of a way to design new strategies for providing an appropriate treatment.

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 In this study, we attempted to analyze the therapeutic effects of PM 014 on inflammation and pulmonary fibrosis in COVID-19 as well as describing the treatment of one of the most challenging problems related to the coronavirus-19 (COVID-19).


Type of Study: Short Communication | Subject: Pharmacology
Received: 2021/02/28 | Accepted: 2021/10/25 | Published: 2022/04/1

References
1. Kuiken T, Taubenberger J. Pathology of human influenza revisited. 2008. 26: p. D59-D66. [DOI:10.1016/j.vaccine.2008.07.025] [PMID] [PMCID]
2. Karbalaie Niya MH, Yavarian J, Shafiei Jandaghi NZ, Shahmahmoodi SH, Mokhtari Azad T. Comparison of real-time RT-PCR assay with direct sequencing for detection of sensitivity or resistant to oseltamivir in influenza A/H3N2 viruses. Virol & Antiviral Res. 2014. 3(1): 122-8. [DOI:10.4172/2324-8955.1000120]
3. Mauad T , Hajjar L, Callegari G, et al., Lung pathology in fatal novel human influenza A (H1N1) infection. Am J Respir Crit Care Med. 2010;181(1): 72-9. [DOI:10.1164/rccm.200909-1420OC] [PMID]
4. Baskin C, Bielefeldt-Ohmann H, Tumpey T,et al. Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus. Proc Natl Acad Sci U S A. 2009. 106(9): 3455-60. [DOI:10.1073/pnas.0813234106] [PMID] [PMCID]
5. Roh GS,Seo SW,Yeo SK,et al. Efficacy of a traditional Korean medicine, Chung-Sang-Bo-Ha-Tang, in a murine model of chronic asthma. Int Immunopharmacol.2005;5(2): 427-36. [DOI:10.1016/j.intimp.2004.09.036] [PMID]
6. Kim J, Shin D, Lee G, et al. Standardized herbal formula PM014 inhibits radiation-induced pulmonary inflammation in mice. Sci Report. 2017; 7(1): 1-11. https://doi.org/10.1016/j.ijrobp.2017.06.2049 [DOI:10.1038/srep45001]
7. Traves S, Culpitt S, Russell R, Barnes P, Donnelly L.Increased levels of the chemokines GROα and MCP-1 in sputum samples from patients with COPD. Thorax. 2002. 57(7): p. 590-595. [DOI:10.1136/thorax.57.7.590] [PMID] [PMCID]
8. Kim K , Lee S , Lee H,et al. A standardized herbal extract PM014 ameliorates pulmonary fibrosis by suppressing the TGF-β1 pathway.Sci Rep. 2018; 8(1): 1-12. [DOI:10.1038/s41598-018-35320-8] [PMID] [PMCID]
9. Spagnolo P , Maher T , Richeldi L,et al., Idiopathic pulmonary fibrosis: recent advances on pharmacological therapy. Pharmacol Ther.2015; 152: 18-27. [DOI:10.1016/j.pharmthera.2015.04.005] [PMID]

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