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Rostami M, Molaei Z, Motamed N. The Relationship between Fecal Myeloperoxidase Concentration and Growth Velocity in 2-5 Year-Old Children in Rural Areas of Zanjan, Iran. J Adv Med Biomed Res 2022; 30 (140) :255-262
URL: http://journal.zums.ac.ir/article-1-6517-en.html
The Relationship between Fecal Myeloperoxidase Concentration and Growth Velocity in 2-5 Year-Old Children in Rural Areas of Zanjan, Iran
Mina Rostami1 , Ziba Molaei * 2, Nima Motamed3
1- Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
2- Dept.of Pediatrics, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran , zibm1400@gmail.com
3- Dept. of Social Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Abstract:   (80181 Views)

Background and Objective: Growth is an important marker of child health. It has been shown recently that a chronic inflammatory condition, known as Environmental Enteric Dysfunction might play a more significant role on growth velocity than clinical infections. The present study aims to investigate the fecal myeloperoxidase concentration (a marker of gut inflammation) and its relationship with growth velocity.
Materials and Methods: In this prospective cohort study, 74 children from rural population of Iran (2 to 5 years of age) were randomly included. The heights and weights of the children were measured at a quarterly interval. The stool samples were obtained from all children in order to measure myeloperoxidase (MPO) concentration. The growth velocity was assessed on the basis of height for age Z-score and weight for age Z-score changes. A questionnaire on socioeconomic status was also completed by children’s parents.
Results: 82 children aged 2 to 5 years (37 females and 45 males) with mean age of 40.63 ± 12.7 months participated in this study. The mean fecal MPO level was 71.26 ng/ml (Min – Max: 2 – 232.33 ng/ml). There was no significant relationship between fecal myeloperoxidase level and changes in height and weight Z scores. Moreover, there was no significant relationship between socioeconomic status of households and fecal myeloperoxidase level.
Conclusion: The mean level of fecal MPO in the present study was lower than similar studies. This significant difference might be mainly due to the better social status of families and environmental conditions of villages in our study.

Keywords: Myeloperoxidase, Biomarkers, Environmental Enteric Dysfunction, Child growth
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✅ The mean level of fecal MPO in the present study was lower than similar studies. This significant difference might be mainly due to the better social status of families and environmental conditions of villages in our study.


Type of Study: Original Article | Subject: Clinical medicine
Received: 2021/04/23 | Accepted: 2021/08/14 | Published: 2022/04/1
References
1. WHO. Global Database on Child Growth and Malnutrition 2018. Available from: https://www.who.int/nutgrowthdb/estimates2017/en/.
2. Kosek M, Haque R, Lima A, et al. Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants. Am J Trop Med Hygiene. 2013;88(2):390-6. [DOI:10.4269/ajtmh.2012.12-0549] [PMID] [PMCID]
3. Branca F, Ferrari M. Impact of micronutrient deficiencies on growth: the stunting syndrome. Ann Nutr & Metab. 2002;46 Suppl 1:8-17. [DOI:10.1159/000066397] [PMID]
4. DeBoer MD, Schar f RJ, Leite AM, et al. Systemic inflammation, growth factors, and linear growth in the setting of infection and malnutrition. Nutrition. 2017;33:248-53. [DOI:10.1016/j.nut.2016.06.013] [PMID] [PMCID]
5. Syed S, Ali A, Duggan C. Environmental enteric dysfunction in children. J Pediatr Gastroenterol Nutr. 2016;63(1):6-14. [DOI:10.1097/MPG.0000000000001147] [PMID] [PMCID]
6. Marie C, Ali A, Chandwe K, Petri WA, Kelly P. Pathophysiology of environmental enteric dysfunction and its impact on oral vaccine efficacy. Mucos Immunol. 2018;11(5):1290-8. [DOI:10.1038/s41385-018-0036-1] [PMID]
7. Abd El-Maksoud AM, Khairy SA, Sharada HM, Abdalla MS, Ahmed NF. Evaluation of pro-inflammatory cytokines in nutritionally stunted Egyptian children. Egypt Pediatr Assoc Gazette. 2017;65(3):80-4. [DOI:10.1016/j.epag.2017.04.003]
8. Bartz S, Mody A, Hornik C, et al. Severe acute malnutrition in childhood: hormonal and metabolic status at presentation, response to treatment, and predictors of mortality. J Clin Endocrinol Metab. 2014;99(6):2128-37. [DOI:10.1210/jc.2013-4018] [PMID] [PMCID]
9. Campbell RK, Schulze KJ, Shaikh S, et al. Environmental enteric dysfunction and systemic inflammation predict reduced weight but not length gain in rural Bangladeshi children. Br J Nutr. 2018;119(4):407-14. [DOI:10.1017/S0007114517003683] [PMID]
10. Cheng WD, Wold KJ, Benzoni NS, et al. Lactoferrin and lysozyme to reduce environmental enteric dysfunction and stunting in Malawian children: study protocol for a randomized controlled trial. Trials. 2017;18(1):523. [DOI:10.1186/s13063-017-2278-8] [PMID] [PMCID]
11. Gilmartin AA, Petri WA. Exploring the role of environmental enteropathy in malnutrition, infant development and oral vaccine response. Philos Trans R Soc Lond B Biol Sci. 2015; 370(1671): 20140143. [DOI:10.1098/rstb.2014.0143] [PMID] [PMCID]
12. Naylor C, Lu M, Haque R, et al. Environmental enteropathy, oral vaccine failure and growth faltering in infants in Bangladesh. EBioMed. 2015;2(11):1759-66. [DOI:10.1016/j.ebiom.2015.09.036] [PMID] [PMCID]
13. George CM, Oldja L, Biswas SK, et al. Fecal markers of environmental enteropathy are associated with animal exposure and caregiver hygiene in Bangladesh. Am J Trop Med Hygiene. 2015;93(2):269-75. [DOI:10.4269/ajtmh.14-0694] [PMID] [PMCID]
14. Arndt MB, Richardson BA, Ahmed T, et al. Fecal markers of environmental enteropathy and subsequent growth in Bangladeshi children. Am J Trop Med Hygiene. 2016;95(3):694-701. [DOI:10.4269/ajtmh.16-0098] [PMID] [PMCID]
15. Chaima D. Characterization of the fecal microbiota of rural Malawian children, associations with biomarkers of environmental enteric dysfunction and the impact of a mass drug administration program. PhD thesis, London School of Hygiene & Tropical Medicine. (2020)
16. WHO child growth standards based on length/height, weight and age. Acta paediatrica (Oslo, Norway : 1992) Supplement. 2006;450:76-85. [DOI:10.1111/j.1651-2227.2006.tb02378.x] [PMID]
17. Kakwani N, Son HH. Global poverty estimates based on 2011 purchasing power parity: where should the new poverty line be drawn? J Economic Inequality. 2016;14(2):173-84. [DOI:10.1007/s10888-016-9322-x]
18. Hansberry DR, Shah K, Agarwal P, Agarwal N. Fecal myeloperoxidase as a biomarker for inflammatory bowel disease. Cureus. 2017;9(1):e1004. [DOI:10.7759/cureus.1004] [PMID] [PMCID]
19. Harper KM, Mutasa M, Prendergast AJ, Humphrey J, Manges AR. Environmental enteric dysfunction pathways and child stunting: A systematic review. PLoS Neglect Trop Disease. 2018;12(1):e0006205. [DOI:10.1371/journal.pntd.0006205] [PMID] [PMCID]
20. Vaz Nery S, Bennett I, Clarke NE, et al. Characterisation of environmental enteropathy biomarkers and associated risk factors in children in the context of a WASH trial in Timor-Leste. Int J Hyg Environ Health. 2018;221(6):901-6. [DOI:10.1016/j.ijheh.2018.05.012] [PMID]
21. Campbell RK, Schulze KJ, Shaikh S, et al. Biomarkers of environmental enteric dysfunction among children in rural Bangladesh. J Pediatr Gastroenterol Nutr. 2017;65(1):40-6. [DOI:10.1097/MPG.0000000000001557] [PMID] [PMCID]
22. George CM, Burrowes V, Perin J, et al. Enteric infections in young children are associated with environmental enteropathy and impaired growth. Trop Med & Int Health. 2018;23(1):26-33. [DOI:10.1111/tmi.13002] [PMID]
23. George CM, Oldja L, Biswas S, et al. Unsafe child feces disposal is associated with environmental enteropathy and impaired growth. J Pediatr. 2016;176:43-9. [DOI:10.1016/j.jpeds.2016.05.035] [PMID]
24. McCormick BJJ, Lee GO, Seidman JC, et al. Dynamics and trends in fecal biomarkers of gut function in children from 1-24 months in the MAL-ED study. Am J Trop Med Hygiene. 2017;96(2):465-72. [DOI:10.4269/ajtmh.16-0496] [PMID] [PMCID]
25. Colston JM, Peñataro Yori P, Colantuoni E, et al. A methodologic framework for modeling and assessing biomarkers of environmental enteropathy as predictors of growth in infants: an example from a Peruvian birth cohort. Am J Clin Nutr. 2017;106(1):245-55. [DOI:10.3945/ajcn.116.151886] [PMID]
26. George CM, Oldja L, Biswas S, et al. Geophagy is associated with environmental enteropathy and stunting in children in rural Bangladesh. Am J Trop Med Hyg. 2015;92(6):1117-24. [DOI:10.4269/ajtmh.14-0672] [PMID] [PMCID]
27. Menzies IS, Zuckerman MJ, Nukajam WS, et al. Geography of intestinal permeability and absorption. Gut. 1999;44(4):483-9. [DOI:10.1136/gut.44.4.483] [PMID] [PMCID]
28. Watanabe K, Petri WA. Environmental enteropathy: Elusive but significant subclinical abnormalities in developing countries. EBioMedicine. 2016;10:25-32. [DOI:10.1016/j.ebiom.2016.07.030] [PMID] [PMCID]
29. Grassly NC, Praharaj I, Babji S, et al. The effect of azithromycin on the immunogenicity of oral poliovirus vaccine: a double-blind randomised placebo-controlled trial in seronegative Indian infants. Lancet Infect Dis. 2016;16: 905-14. [DOI:10.1016/S1473-3099(16)30023-8]
30. Korpela K, Salonen A, Virta L, et al. Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children. Nat Commun 7. 2016(10410). [DOI:10.1038/ncomms10410] [PMID] [PMCID]
31. Rahkar Farshi M, Ahmadian Heris J, Ebadi Z, Abdinia B. A Description of mothers' knowledge and practice about antibiotic use in children in northwest of Iran. Int J Pediatr 2020; 8(11): 12349-356.
32. Nabovati E, TaherZadeh Z, Eslami S, et al. Antibiotic prescribing in inpatient and outpatient settings in Iran: a systematic review and meta-analysis study. Antimicrob Resist Infect Control. 2021 10: 15. [DOI:10.1186/s13756-021-00887-x] [PMID] [PMCID]
33. Mostafavi N, Rashidian A, Karimi-Shahanjarini A, Khosravi A, Kelishadi R. The rate of antibiotic utilization in Iranian under 5-year-old children with acute respiratory tract illness: A nationwide community-based study. J Res Med Sci. 2015;20(5):429-33. [DOI:10.4103/1735-1995.163952] [PMID] [PMCID]
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