Fri, Oct 11, 2024
[Archive]
Volume 32, Issue 151 (March & April 2024)
J Adv Med Biomed Res 2024, 32(151): 111-118 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Binesh S, Ghorbani R, Mansori K, Taheri R. The Relationship between Vitiligo and Hearing Loss: A Case-Control Study. J Adv Med Biomed Res 2024; 32 (151) :111-118
URL: http://journal.zums.ac.ir/article-1-7281-en.html
URL: http://journal.zums.ac.ir/article-1-7281-en.html
1- Semnan University of Medical Sciences , Sahar_b@gmail.com
2- Semnan University of Medical Sciences
3- Zanjan University of Medical Sciences
2- Semnan University of Medical Sciences
3- Zanjan University of Medical Sciences
Abstract: (202 Views)
Background & Objective: Vitiligo as an acquired disorder is caused by the gradual loss of functional melanocytes. Aiming to assess whether vitiligo is associated with hearing loss.
Materials & Methods: A population based case-control study (case, n= 50; control, n=51). The case group included all vitiligo patients referred to public and private clinics in Semnan in March 2021 to October 2021. Then, for each case, one control was selected from the people who did not have any skin disease and had only visited the same center for cosmetic procedures. Audiometric tests including pure tone audiometry (PTA), speech discrimination score (SDS), speech reception threshold (SRT), acoustic reflex (AR) and tympanometry were performed for both case and control groups.
Results: The mean of age (±SD) was 31.3 (8.5) and 33.5 (7.9) in two groups. The numbers (%) of women were 32 (64%) and 27 (52.9%); respectively. The result of AR test was normal in 80% of the patients and 92% of the control group; respectively. PTA test result was abnormal in 18 and 2% of cases and controls, respectively. SDS, SRT and Tympanometry Tests were normal in all people of the two groups under investigation. However, the odds of having an abnormal PTA test in vitiligo patients was 10.97 times that of healthy people (OR=10.97; 95% CI: 1.39 – 15.38) (P=0.007).
Conclusion: A relationship was observed between vitiligo and hearing loss, so regular hearing checks are recommended in these patients.
Materials & Methods: A population based case-control study (case, n= 50; control, n=51). The case group included all vitiligo patients referred to public and private clinics in Semnan in March 2021 to October 2021. Then, for each case, one control was selected from the people who did not have any skin disease and had only visited the same center for cosmetic procedures. Audiometric tests including pure tone audiometry (PTA), speech discrimination score (SDS), speech reception threshold (SRT), acoustic reflex (AR) and tympanometry were performed for both case and control groups.
Results: The mean of age (±SD) was 31.3 (8.5) and 33.5 (7.9) in two groups. The numbers (%) of women were 32 (64%) and 27 (52.9%); respectively. The result of AR test was normal in 80% of the patients and 92% of the control group; respectively. PTA test result was abnormal in 18 and 2% of cases and controls, respectively. SDS, SRT and Tympanometry Tests were normal in all people of the two groups under investigation. However, the odds of having an abnormal PTA test in vitiligo patients was 10.97 times that of healthy people (OR=10.97; 95% CI: 1.39 – 15.38) (P=0.007).
Conclusion: A relationship was observed between vitiligo and hearing loss, so regular hearing checks are recommended in these patients.
Type of Study: Original Article |
Subject:
Clinical medicine
Received: 2023/06/26 | Accepted: 2024/02/18 | Published: 2024/03/2
Received: 2023/06/26 | Accepted: 2024/02/18 | Published: 2024/03/2
References
1. Mirnezami M, Rahimi H. Serum zinc level in vitiligo: A case-control study. Indian J Dermatol. 2018;63(3):227.
2. Sinani A, Roshi E, Lico R, Fida M, Dajci V. A study on the prevalence and dermatology life quality index on vitiligo in Tirana, Albania. Balkan Milit Med Rev. 2015;18(4). [DOI:10.5455/bmmr.189331]
3. Zhang Y, Cai Y, Shi M, et al. The prevalence of vitiligo: a meta-analysis. PloS one. 2016;11(9):e0163806. [DOI:10.1371/journal.pone.0163806] [PMID] [PMCID]
4. Zokaei S, Farhud DD, Keykhaei M, Yeganeh MZ, Rahimi H, Moravvej H. Cultured epidermal melanocyte transplantation in vitiligo: a review article. Iran J Pub Health. 2019;48(3):388. [DOI:10.18502/ijph.v48i3.881]
5. Anbar T, Westerhof W, Abdel‐Rahman A, El‐Khayyat M. Evaluation of the effects of NB‐UVB in both segmental and non‐segmental vitiligo affecting different body sites. Photodermatol, Photoimmunol Photomed. 2006;22(3):157-63. [DOI:10.1111/j.1600-0781.2006.00222.x] [PMID]
6. Tayyebi Meibodi N, Javidi Z, Mahmodi M, et al. Evaluation of subtypes of peripheral blood lymphocytes in patients with vitiligo.J Mashhad Univ Med Sci. 2009;52(4):198-202.
7. Zhang XJ, Liu JB, Gui JP, et al. Characteristics of genetic epidemiology and genetic models for vitiligo. J Am Acad Dermatol. 2004;51(3):383-90. [DOI:10.1016/j.jaad.2003.12.044] [PMID]
8. Malhotra N, Dytoc M. The pathogenesis of vitiligo. J Cutan Med Surg. 2013;17(3):153-72. [DOI:10.2310/7750.2012.12005] [PMID]
9. Guerra L, Dellambra E, Brescia S, Raskovic D. Vitiligo: pathogenetic hypotheses and targets for current therapies. Curr Drug Metab. 2010;11(5):451-67. [DOI:10.2174/138920010791526105] [PMID]
10. Aydogan K, Turan O, Onart S, Karadogan S, Tunali S. Audiological abnormalities in patients with vitiligo. Exper Dermatol. 2006;31(1):110-3. [DOI:10.1111/j.1365-2230.2005.02004.x] [PMID]
11. Araki S, Mizuta K, Takeshita T, Morita H, Mineta H, Hoshino T. Degeneration of the stria vascularis during development in melanocyte-deficient mutant rats (Ws/Ws rats). Europ Arch Oto-rhino-laryngol. 2002;259(6):309-15. [DOI:10.1007/s00405-002-0480-z] [PMID]
12. Mohamed ES, Said EA, Sayed DS, Awad SM, Ahmed MH. Auditory system dysfunction in patients with vitiligo: is it a part of a systemic autoimmune process? Egypt J Otolaryngol. 2017;33(3):594-602. [DOI:10.4103/ejo.ejo_6_17]
13. Shalaby ME-S, El-Zarea GA, Nassar A. Auditory function in vitiligo patients. Egypt Dermatol Online J. 2006;2(1):1.
14. Ezzedine K, Sheth V, Rodrigues M, et al. Vitiligo is not a cosmetic disease. J Am Acad Dermatol. 2015;73(5):883-5. [DOI:10.1016/j.jaad.2015.07.039] [PMID]
15. Bainbridge KE, Wallhagen MI. Hearing loss in an aging American population: extent, impact, and management. Ann Rev Pub Health. 2014;35:139-52. [DOI:10.1146/annurev-publhealth-032013-182510] [PMID]
16. Shukla A, Harper M, Pedersen E, et al. Hearing loss, loneliness, and social isolation: a systematic review. Otolaryngol Head Neck Surg. 2020;162(5):622-33. [DOI:10.1177/0194599820910377] [PMID] [PMCID]
17. Kawakami T, Hashimoto T. Disease severity indexes and treatment evaluation criteria in vitiligo. Dermatol Res Pract. 2011;2011. [DOI:10.1155/2011/750342] [PMID] [PMCID]
18. Moghaddam AY, Sayyah M, Fini EA, Talaee R. Investigation the relationship between skin involvement severity and hearing loss severity in vitiligo patients. Materia Socio-Medica. 2018;30(1):29. [DOI:10.5455/msm.2018.30.29-31] [PMID] [PMCID]
19. Rahimi H, Mozafari N, Bastaninejad S, Tehranchinia Z, Samani NA. Hearing status in patients with vitiligo. Clin Cosmet Investig Dermatol. 2019;12:445. [DOI:10.2147/CCID.S201012] [PMID] [PMCID]
20. Al-Mutairi N, Al-Sebeih K. Late onset vitiligo and audiological abnormalities: Is there any association? Indian J Dermatol Venereol Leprol. 2011;77(5):571. [DOI:10.4103/0378-6323.84059] [PMID]
21. Escalante-Ugalde C, Poblano A, de Oca EM, Lagunes R, Saúl A. No evidence of hearing loss in patients with vitiligo. Arch Dermatol. 1991;127(8):1240-. [DOI:10.1001/archderm.1991.01680070142026] [PMID]
22. Lien KH, Ger TY, Chi CC. Association of vitiligo with high‐frequency sensorineural hearing loss: a systematic review and meta‐analysis. J Europ Acad Dermatol Venereol. 2022;36(3):373-9. [DOI:10.1111/jdv.17815] [PMID]
23. Ma SH, Ang MD, Chang YT, Dai YX. Association between vitiligo and hearing loss. J Am Acad Dermatol. 2021;85(6):1465-72. [DOI:10.1016/j.jaad.2020.12.029] [PMID]
24. Murillo-Cuesta S, Contreras J, Zurita E, et al. Melanin precursors prevent premature age-related and noise -induced hearing loss in albino mice. Pigment Cell Melanoma Res 2010; 23(1): 72-83. . [DOI:10.1111/j.1755-148X.2009.00646.x] [PMID]
25. Shajil E, Chatterjee S, Agrawal D, Bagchi T, Begum R. Vitiligo: pathomechanisms and genetic polymorphism of susceptible genes..Indian J Exp Biol.2006;44(7):526-39.
26. Liu X, Yan D. Ageing and hearing loss. J Pathol. 2007;211(2):188-97. [DOI:10.1002/path.2102] [PMID]
27. Perossini M, Turio E, Perossini T, Cei G, Barachini P. Vitiligo: ocular and electrophysiological findings. Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Societa Italiana di Dermatologia e Sifilografia. 2010;145(2):141-9.
28. Elsaied MA, Naga YAA, Abdo A. Evaluation of brain stem auditory evoked response in vitiligo patients. J Pan-Arab League Dermatologists. 2008;19(1):91-7.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Copyright Policy
