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Volume 31, Issue 148 (September & October 2023)
J Adv Med Biomed Res 2023, 31(148): 499-506 |
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Naser Al-Jabery R, Ajah. Auda M, Yosif Al-Rekabi H. Anticancer Potential of Phenolic Extract from Spirulina Platensis Against Esophagus Cancer Cells. J Adv Med Biomed Res 2023; 31 (148) :499-506
URL: http://journal.zums.ac.ir/article-1-7355-en.html
URL: http://journal.zums.ac.ir/article-1-7355-en.html
1- Dept. of Chemistry, College of Science, University of Thi-Qar, Thi-Qar, Iraq , rasha_na.ch@sci.utq.edu.iq
2- Dept. of Chemistry, College of Science, University of Thi-Qar, Thi-Qar, Iraq
3- Technical Institute Al-Nassiriah, Southern Technical University, Thi-Qar, Iraq
2- Dept. of Chemistry, College of Science, University of Thi-Qar, Thi-Qar, Iraq
3- Technical Institute Al-Nassiriah, Southern Technical University, Thi-Qar, Iraq
Abstract: (1270 Views)
Background and Objective: Algae phenolic extracts have received special attention because of their effective and efficient antioxidant properties and their obvious effects in inhibiting various diseases related to oxidative stress, such as cancer. This study aimed to document the phenolic extract of Spirulina platensis against cancer cell line SK-GT-4 and regular cell line HBL100.
Materials and Methods: Phenolic compounds were extracted from S. platensis, and the extract was checked for its anticancer activity by MTT. The constituents of phenolic extract were analyzed using high-performance liquid chromatography (HPLC).
Results: The results showed that the half maximal inhibitory concentration value for Phenolic extract was 36.52 µg/mL for 50% of cell death. HPLC analysis revealed that the compounds with possible therapeutic effects are gallic acid, ferulic acid, cinnamic acid, syringic acid, and vanillic acid, which have anticancer activity.
Conclusion: The results of this study point out that the S. platensis phenolic extract has anticancer potential, and the phytoconstituents contributed to the anticancer effects.
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✅ The results of this study point out that the S. platensis phenolic extract has anticancer potential, and the phytoconstituents contributed to the anticancer effects.
Type of Study: Original Article |
Subject:
Clinical medicine
Received: 2023/08/8 | Accepted: 2023/10/20 | Published: 2023/10/29
Received: 2023/08/8 | Accepted: 2023/10/20 | Published: 2023/10/29
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