Volume 32, Issue 152 (May & June 2024)                   J Adv Med Biomed Res 2024, 32(152): 235-239 | Back to browse issues page


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Abdoli A, Najafi A, Sayyah M K, Bagheri-Josheghani S, Najafizadeh M. A Case Report of CMV-Associated Encephalitis. J Adv Med Biomed Res 2024; 32 (152) :235-239
URL: http://journal.zums.ac.ir/article-1-7364-en.html
1- Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
2- Department of Infectious Diseases, Kashan University of Medical Sciences, Kashan, Iran
3- Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran , Dr.maedeh.najafizadeh@gmail.com
Abstract:   (229 Views)
Cytomegalovirus (CMV) infection is not common in immunocompetent patient. This study is a case report of a 60-year-old man with no evidence of immunocompromised history, who died from CMV-associated encephalitis. The patient presented with a 5-month headache whose pattern and severity changed in the past few days, coffee ground vomiting, and three times seizure. The condition caused his level of consciousness to decrease, he didn’t respond to the primary empirical treatment, and the primary paraclinical work up had no specific findings. Magnetic resonance imaging (MRI) showed normal pressure hydrocephalus, and cerebrospinal fluid (CSF) analysis had aseptic pattern, blood culture was negative, and CSF culture was negative too. After that multiplex polymerase chain reaction (PCR) was done on the CSF, which was positive for CMV. Foscarnet therapy was initiated for the patient, but it was too late, and the patient did not respond to these treatments. Finally, the patient died. It is too important to diagnose these conditions and initiate therapy as soon as possible.
 
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Type of Study: Case report | Subject: Health improvement strategies
Received: 2023/09/30 | Accepted: 2024/05/21 | Published: 2024/06/21

References
1. Drago F, Karpasitou K, Spinardi L, Crespiatico L, Scalamogna M, Poli F, et al. Human cytomegalovirus (HCMV)-revised. Transfus Med Hemother. 2010;37(6):365-75. [DOI:10.1159/000322141]
2. Baghban A, Malinis M. Ganciclovir and foscarnet dual-therapy for cytomegalovirus encephalitis: a case report and review of the literature. J Neurol Sci. 2018;388:28-36. [DOI:10.1016/j.jns.2018.02.029]
3. Ramanan P, Razonable RR. Cytomegalovirus infections in solid organ transplantation: a review. Infect Chemother. 2013;45(3):260-71. [DOI:10.3947/ic.2013.45.3.260]
4. Narvaneni S, Tagliaferri AR, Reid R-J, Horani G, Maroules M. A case of cytomegalovirus encephalitis in cluster of differentiation four cell counts greater than 50. Cureus. 2021;13(10). [DOI:10.7759/cureus.18550]
5. Xu X, Bergman P, Willows T, Tammik C, Sund M, Hökfelt T, et al. CMV-associated encephalitis and antineuronal autoantibodies-a case report. BMC Neurol. 2012;12:1-7. [DOI:10.1186/1471-2377-12-87]
6. Newcomb G, Mariuz P, Lachant D. CMV encephalitis/radiculitis: the difficulty in diagnosing in an intubated patient. Case Report Crit Care. 2019;2019(1):8067648. [DOI:10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A6651]
7. Meryana M. Citomegalovirus (Cmv) encephalitis: A case report. J Widya Medika. 2022;8(1):67-75.
8. Maschke M, Kastrup O, Diener HC. CNS manifestations of cytomegalovirus infections: diagnosis and treatment. CNS Drug. 2002;16:303-15. [DOI:10.2165/00023210-200216050-00003]
9. Tetsuka S, Suzuki T, Ogawa T, Hashimoto R, Kato H. Encephalopathy associated with severe cytomegalovirus infection in an immunocompetent young woman. Case Report Infect Dis. 2021;2021(1):5589739. [DOI:10.1155/2021/5589739]
10. Prösch S, Schielke E, Reip A, Meisel H, Volk H-D, Einhäupl KM, et al. Human cytomegalovirus (HCMV) encephalitis in an immunocompetent young person and diagnostic reliability of HCMV DNA PCR using cerebrospinal fluid of nonimmunosuppressed patients. J Clin Microbiol. 1998;36(12):3636-40. [DOI:10.1128/JCM.36.12.3636-3640.1998]
11. Wildemann B, Haas J, Lynen N, Stingele K, Storch-Hagenlocher B. Diagnosis of cytomegalovirus encephalitis in patients with AIDS by quantitation of cytomegalovirus genomes in cells of cerebrospinal fluid. Neurol. 1998;50(3):693-7. [DOI:10.1212/WNL.50.3.693]

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