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Volume 32, Issue 154 (September & October 2024)
J Adv Med Biomed Res 2024, 32(154): 386-392 |
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Hassanpour S, Hajimoradi S, Malekpour F. Antiepileptic Role of β-alanine on Pentylenetetrazol-Induced Convulsions during Estrus Cycle in Rat. J Adv Med Biomed Res 2024; 32 (154) :386-392
URL: http://journal.zums.ac.ir/article-1-7382-en.html
URL: http://journal.zums.ac.ir/article-1-7382-en.html
1- Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran , hassanpour.shahin@gmail.com
2- Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
3- Iran University of Medical Sciences, Tehran, Iran
2- Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
3- Iran University of Medical Sciences, Tehran, Iran
Abstract: (142 Views)
Background & Objective: Epilepsy is one of the main neurological disorders and β-alanine has several beneficial in the nervous system.This study aimed to determine the antiepileptic effect of the β-alanine during estrous cycle in pentylenetetrazol (PTZ)-induced seizures in rat.
Materials & Methods: Thirty female rats were allocated into five experimental groups as control, sodium valproate (75 mg/kg), and β-alanine (15, 30 and 45 mg/kg) during estrus cycle (proestrus, estrus, metestrus and diestrus). Puberty was determined by vaginal smears whereby animals with two normal cycles were chosen. After administration of the sodium valproate or β-alanine, PTZ injection (80 mg/kg, i.p) was done. Animals were monitored for 30 minutes with initiation time of myoclonic seizures (ITMS), initiation time of tonic–clonic seizures (ITTS), and seizures’ duration (SD) registered.
Results: Based on the findings, β-alanine (30 and 45 mg/kg) significantly increased the onset time of ITMS and ITTS compared to the control group (P<0.05). β-alanine (30 and 45 mg/kg) significantly reduced SD compared to the control group (P<0.05). The antiepileptic effect of β-alanine was more prominent during metestrus and diestrus than proestrus and estrus (P<0.05).
Conclusion: It seems β-alanine has antiepileptic effects which are more prominent during proestrus and estrus than metestrus and diestrus.
Materials & Methods: Thirty female rats were allocated into five experimental groups as control, sodium valproate (75 mg/kg), and β-alanine (15, 30 and 45 mg/kg) during estrus cycle (proestrus, estrus, metestrus and diestrus). Puberty was determined by vaginal smears whereby animals with two normal cycles were chosen. After administration of the sodium valproate or β-alanine, PTZ injection (80 mg/kg, i.p) was done. Animals were monitored for 30 minutes with initiation time of myoclonic seizures (ITMS), initiation time of tonic–clonic seizures (ITTS), and seizures’ duration (SD) registered.
Results: Based on the findings, β-alanine (30 and 45 mg/kg) significantly increased the onset time of ITMS and ITTS compared to the control group (P<0.05). β-alanine (30 and 45 mg/kg) significantly reduced SD compared to the control group (P<0.05). The antiepileptic effect of β-alanine was more prominent during metestrus and diestrus than proestrus and estrus (P<0.05).
Conclusion: It seems β-alanine has antiepileptic effects which are more prominent during proestrus and estrus than metestrus and diestrus.
Type of Study: Original Article |
Subject:
Pharmacology
Received: 2023/10/31 | Accepted: 2025/01/1 | Published: 2024/10/19
Received: 2023/10/31 | Accepted: 2025/01/1 | Published: 2024/10/19
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