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Volume 32, Issue 154 (September & October 2024)
J Adv Med Biomed Res 2024, 32(154): 361-369 |
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Mohammadi N, Eslami B, Seyedalipour B, Joz Jalalian E. The rs739837 Polymorphism of Vitamin D Receptor Gene and Its Relationship with Type 2 Diabetes Mellitus in the Eastern Population of Mazandaran Province. J Adv Med Biomed Res 2024; 32 (154) :361-369
URL: http://journal.zums.ac.ir/article-1-7413-en.html
URL: http://journal.zums.ac.ir/article-1-7413-en.html
1- Department. of Biology, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran
2- Department of Molecular and Cell Biology, Faculty of Basic Science, University of Mazandaran, Babolsar, Iran ,b.alipour81@gmail.com
3- Department of Molecular and Cell Biology, Faculty of Basic Science, University of Mazandaran, Babolsar, Iran
2- Department of Molecular and Cell Biology, Faculty of Basic Science, University of Mazandaran, Babolsar, Iran ,
3- Department of Molecular and Cell Biology, Faculty of Basic Science, University of Mazandaran, Babolsar, Iran
Abstract: (134 Views)
Background & Objective: The relationship between vitamin D receptor (VDR). Polymorphisms, and diabetes remain uncertain. This study aimed to examine the potential correlation between type 2 diabetes mellitus (T2DM) and rs739837 single nucleotide polymorphism (SNP) in the Mazandaran province population.
Materials & Methods: A case-control study was conducted, involving 100 individuals diagnosed with T2DM and 100 healthy controls, all residents of Mazandaran province. The extraction of genomic DNA and rs739837 polymorphism was genotyped using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method.
Results: The data indicated a significant association between GT genotype and a decreased risk of T2DM (OR= 0.5135, 95%CI= 0.2759 to 0.9559, P=0.0355). Moreover, individuals carrying T allele showed a reduced likelihood of progressing T2DM (OR= 0.4657, 95%CI= 0.2564 to 0.8461, P=0.0121).
Conclusion: The findings suggested that rs739837 polymorphism in the VDR gene may serve as a protective factor against T2DM in the studied population. Further research with larger samples is needed to confirm these results across different populations.
Materials & Methods: A case-control study was conducted, involving 100 individuals diagnosed with T2DM and 100 healthy controls, all residents of Mazandaran province. The extraction of genomic DNA and rs739837 polymorphism was genotyped using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method.
Results: The data indicated a significant association between GT genotype and a decreased risk of T2DM (OR= 0.5135, 95%CI= 0.2759 to 0.9559, P=0.0355). Moreover, individuals carrying T allele showed a reduced likelihood of progressing T2DM (OR= 0.4657, 95%CI= 0.2564 to 0.8461, P=0.0121).
Conclusion: The findings suggested that rs739837 polymorphism in the VDR gene may serve as a protective factor against T2DM in the studied population. Further research with larger samples is needed to confirm these results across different populations.
Type of Study: Original Article |
Subject:
Medical Biology
Received: 2023/12/20 | Accepted: 2024/12/31 | Published: 2024/10/19
Received: 2023/12/20 | Accepted: 2024/12/31 | Published: 2024/10/19
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