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Volume 32, Issue 154 (September & October 2024)
J Adv Med Biomed Res 2024, 32(154): 341-349 |
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Monadi M, Ranaee M, Omranpour Bandpey H, Qujeq D. Serum Levels of Factor XIII, D-dimer, and Fibrinogen as A non-Invasive Diagnostic Biomarkers in Patients with Venous Thromboembolism. J Adv Med Biomed Res 2024; 32 (154) :341-349
URL: http://journal.zums.ac.ir/article-1-7492-en.html
URL: http://journal.zums.ac.ir/article-1-7492-en.html
1- Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran , Dr.monadi@yahoo.com
2- Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
3- Dept. of Internal Medicine, School of Medicine, Babol University of Medical Sciences, Babol, Iran
4- Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran
2- Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
3- Dept. of Internal Medicine, School of Medicine, Babol University of Medical Sciences, Babol, Iran
4- Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran
Abstract: (136 Views)
Background & Objective: Using new diagnostic methods to help quickly diagnose VTE disease is important. It is well known that treatment of VTE is based on radiological methods, but the main purpose of this research was to investigate the relationship between blood coagulation factor XIII( FXIII), D-dimer, and fibrinogen levels in patients with VTE.
Materials & Methods: Seventy patients initially suspected of having VTE were included and determined their D-dimer, fibrinogen, and (FXIII )levels. The diagnosis of VTE was based on the CT-Angiography. The blood samples were prepared from the patients during the first 6 hours of admission and before using anticoagulant.
Results: The mean level of D-dimer in VTE patients was higher than those without VTE (1770± 764.49 vs. 430.66± 263.98ng / ml) (p <0.001). The mean factor XIII level in patients with VTE was significantly lower than those without VTE(55.03±13.61 vs. 88.57±18.14ng / ml) (p <0.001). The mean fibrinogen level in patients with VTE was significantly lower than in non-VTE patients (140.49± 36.03 vs. 214.69± 69.73 mg/dl) (p <0.001). The cut-off value of D-dimer was 500 ng/ml, and the sensitivity and specificity were 97% and 74%, respectively. The cut-off point of fibrinogen was 168 mg/dl, with a sensitivity of and a specificity of 77% and 77%, respectively. The cut-off point of XIII was 70 ng/ml, with a sensitivity of and specificity85% and 82%, respectively.
Conclusion: Our findings suggest that combined measurement of serum levels of D-dimer, factor XIII, and fibrinogen can be used to confirm clinical suspicion for VTE.
Materials & Methods: Seventy patients initially suspected of having VTE were included and determined their D-dimer, fibrinogen, and (FXIII )levels. The diagnosis of VTE was based on the CT-Angiography. The blood samples were prepared from the patients during the first 6 hours of admission and before using anticoagulant.
Results: The mean level of D-dimer in VTE patients was higher than those without VTE (1770± 764.49 vs. 430.66± 263.98ng / ml) (p <0.001). The mean factor XIII level in patients with VTE was significantly lower than those without VTE(55.03±13.61 vs. 88.57±18.14ng / ml) (p <0.001). The mean fibrinogen level in patients with VTE was significantly lower than in non-VTE patients (140.49± 36.03 vs. 214.69± 69.73 mg/dl) (p <0.001). The cut-off value of D-dimer was 500 ng/ml, and the sensitivity and specificity were 97% and 74%, respectively. The cut-off point of fibrinogen was 168 mg/dl, with a sensitivity of and a specificity of 77% and 77%, respectively. The cut-off point of XIII was 70 ng/ml, with a sensitivity of and specificity85% and 82%, respectively.
Conclusion: Our findings suggest that combined measurement of serum levels of D-dimer, factor XIII, and fibrinogen can be used to confirm clinical suspicion for VTE.
Type of Study: Original Article |
Subject:
Clinical medicine
Received: 2024/04/27 | Accepted: 2024/10/12 | Published: 2024/10/19
Received: 2024/04/27 | Accepted: 2024/10/12 | Published: 2024/10/19
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