پنجشنبه 14 آبان 1405
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Ethics code: IR.GUMS.AEC.1403.004
چکیده: (604 مشاهده)
Objective: Metabolic syndrome (MS) is one of the most common disorders in post-menopausal women, which lacks effective, and safe treatment. The bioflavonoid of Hesperidin (Hsp) has beneficial effects in different disorders like cancer and cardiovascular disorders. This study aimed to investigate the interactive effect of supplementation with Hsp and 8-weeks moderate-intensity continuous training (MICT) on insulin resistance, body weight and dyslipidemia in a menopause-induced MS model in rats.
Methods: A total of 40 ovariectomized (OVX) Wistar rats were divided into five groups: control (OVX+Saline), exercise (Exe) (OVX + Exe), Hsp (Hsp) (OVX + Hsp), exercise and Hsp (OVX + Exe + Hsp), and sham-operated. Treatment included either intraperitoneal (i.p) injection of Hsp or saline injection, and also MICT training for 8 weeks. After the end of the treatment, body weight, body mass index (BMI), waist circumference (WC), visceral fat, and serum concentrations of glucose, insulin and lipid profile were measured using colorimetric analysis and ELISA.
Results: Data revealed a significant decrease in weight, waist circumference visceral fat, BMI and levels of glucose, homeostasis model assessment of insulin resistance, triacylglyceride, total cholesterol(p= 0.001), and low-density lipoprotein (LDL) (p= 0.004), but an increase in high-density lipoprotein (p= 0.001)), in OVX+Exe+Hsp compared with the OVX group.
Conclusions: The present study indicates that bioflavonoid Hsp combined with MICT effectively reduces body weight, visceral fat, and LDL, glucose, insulin resistance.
Methods: A total of 40 ovariectomized (OVX) Wistar rats were divided into five groups: control (OVX+Saline), exercise (Exe) (OVX + Exe), Hsp (Hsp) (OVX + Hsp), exercise and Hsp (OVX + Exe + Hsp), and sham-operated. Treatment included either intraperitoneal (i.p) injection of Hsp or saline injection, and also MICT training for 8 weeks. After the end of the treatment, body weight, body mass index (BMI), waist circumference (WC), visceral fat, and serum concentrations of glucose, insulin and lipid profile were measured using colorimetric analysis and ELISA.
Results: Data revealed a significant decrease in weight, waist circumference visceral fat, BMI and levels of glucose, homeostasis model assessment of insulin resistance, triacylglyceride, total cholesterol(p= 0.001), and low-density lipoprotein (LDL) (p= 0.004), but an increase in high-density lipoprotein (p= 0.001)), in OVX+Exe+Hsp compared with the OVX group.
Conclusions: The present study indicates that bioflavonoid Hsp combined with MICT effectively reduces body weight, visceral fat, and LDL, glucose, insulin resistance.
فهرست منابع
1. Ko SH, Kim HS. Menopause-associated lipid metabolic disorders and foods beneficial for postmenopausal women. Nutrients. 2020;12(1):202. [DOI:10.3390/nu12010202] [PMID] [PMCID]
2. Saklayen MG. The global epidemic of the metabolic syndrome. Curr Hypertens Rep. 2018;20(2):12. [DOI:10.1007/s11906-018-0812-z] [PMID]
3. Babaei P, Mehdizadeh R, Ansar MM, Damirchi A. Effects of ovariectomy and estrogen replacement therapy on visceral adipose tissue and serum adiponectin levels in rats. Menopause Int. 2010;16(3):100-4. [DOI:10.1258/mi.2010.010028] [PMID]
4. Pedersen BK, Saltin B. Exercise as medicine: evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports. 2015;25 Suppl 3:1-72. [DOI:10.1111/sms.12581] [PMID]
5. Selvaraj NR, Nandan D, Nair BG, Nair VA, Venugopal P, Aradhya R. Oxidative stress and redox imbalance: common mechanisms in cancer stem cells and neurodegenerative diseases. Cells. 2025;14(7):511. [DOI:10.3390/cells14070511] [PMID] [PMCID]
6. Rahim HA, Damirchi A, Babaei P. Comparison of HIIT and MICT and further detraining on metabolic syndrome and asprosin signaling pathway in metabolic syndrome model of rats. Sci Rep. 2024;14(1):11313. [DOI:10.1038/s41598-024-61842-5] [PMID] [PMCID]
7. Hussain SR, Macaluso A, Pearson SJ. High-intensity interval training versus moderate-intensity continuous training in the prevention/management of cardiovascular disease. Cardiol Rev. 2016;24(6):273-81. [DOI:10.1097/CRD.0000000000000124] [PMID]
8. Ashton RE, Tew GA, Aning JJ, Gilbert SE, Lewis L, Saxton JM. Effects of short-term, medium-term and long-term resistance exercise training on cardiometabolic health outcomes in adults: systematic review with meta-analysis. Br J Sports Med. 2020;54(6):341-8. [DOI:10.1136/bjsports-2017-098970] [PMID]
9. Fedewa MV, Hathaway ED, Ward-Ritacco CL. Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials. Br J Sports Med. 2017;51(8):670-6. [DOI:10.1136/bjsports-2016-095999] [PMID]
10. Sun ZW, Sun ZX, Zhao Y, Zhang L, Xie F, Wang X, et al. Rutin ameliorates stress-induced blood-brain barrier dysfunction and cognitive decline via the endothelial HDAC1-Claudin-5 axis. Fluids Barriers CNS. 2025;22(1):35. [DOI:10.1186/s12987-025-00639-8] [PMID] [PMCID]
11. Salehy MV, Babaei P, Ghaffarkandi ZN, Ghazizadeh F. Neuroprotective effects of natural products against doxorubicin-induced chemobrain: a narrative review of preclinical animal studies. Brain Disord. 2025;20:100284. [DOI:10.1016/j.dscb.2025.100284]
12. Sakakibara H, Shimoi K. Anti-stress effects of polyphenols: animal models and human trials. Food Funct. 2020;11(7):5702-17. [DOI:10.1039/D0FO01129K] [PMID]
13. Pyrzynska K. Hesperidin: a review on extraction methods, stability and biological activities. Nutrients. 2022;14(12):2387. [DOI:10.3390/nu14122387] [PMID] [PMCID]
14. Bayat Z, Damirchi A, Hasannejad-Bibalan M, Babaei P. Metabotropic effect of probiotic supplementation and high-intensity interval training in menopause-induced metabolic syndrome in rats. J Menopausal Med. 2023;29(1):29-39. [DOI:10.6118/jmm.22037] [PMID] [PMCID]
15. Gloy V, Langhans W, Hillebrand JJ, Geary N, Asarian L. Ovariectomy and overeating palatable, energy-dense food increase subcutaneous adipose tissue more than intra-abdominal adipose tissue in rats. Biol Sex Differ. 2011;2:6. [DOI:10.1186/2042-6410-2-6] [PMID] [PMCID]
16. Bayat Z, Damirchi A, Hasannejad-Bibalan M, Babaei P. Concurrent high-intensity interval training and probiotic supplementation improve associative memory via increase in insulin sensitivity in ovariectomized rats. BMC Complement Med Ther. 2023;23(1):262. [DOI:10.1186/s12906-023-04097-3] [PMID] [PMCID]
17. Donato F, de Gomes MG, Goes AT, Filho CB, Del Fabbro L, Antunes MS, et al. Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: possible role of L-arginine-NO-cGMP pathway and BDNF levels. Brain Res Bull. 2014;104:19-26. [DOI:10.1016/j.brainresbull.2014.03.004] [PMID]
18. Assis L, Milares L, Almeida T, Tim C, Magri A, Fernandes K, et al. Aerobic exercise training and low-level laser therapy modulate inflammatory response and degenerative process in an experimental model of knee osteoarthritis in rats. Osteoarthritis Cartilage. 2016;24(1):169-77. [DOI:10.1016/j.joca.2015.07.020] [PMID] [PMCID]
19. Fayaz E, Damirchi A, Zebardast N, Babaei P. Cinnamon extract combined with high-intensity endurance training alleviates metabolic syndrome via non-canonical WNT signaling. Nutrition. 2019;65:173-8. [DOI:10.1016/j.nut.2019.03.009] [PMID]
20. Damirchi A, Mehdizadeh R, Ansar MM, Soltani B, Babaei P. Effects of aerobic exercise training on visceral fat and serum adiponectin concentration in ovariectomized rats. Climacteric. 2010;13:171-8. [DOI:10.3109/13697130903360234] [PMID]
21. Babaei P, Damirchi A, Hoseini R. The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats. J Exerc Nutr Biochem. 2015;19(3):173-82. [DOI:10.5717/jenb.2015.15070703]
22. Liou K, Ho S, Fildes J, Ooi SY. High intensity interval versus moderate intensity continuous training in patients with coronary artery disease: a meta-analysis of physiological and clinical parameters. Heart Lung Circ. 2016;25(2):166-74. [DOI:10.1016/j.hlc.2015.06.828] [PMID]
23. Treml J, Šmejkal K. Flavonoids as potent scavengers of hydroxyl radicals. Compr Rev Food Sci Food Saf. 2016;15(4):720-38. [DOI:10.1111/1541-4337.12204] [PMID] [PMCID]
24. Ji Z, Deng W, Chen D, Liu Z, Shen Y, Dai J, et al. Recent understanding of the mechanisms of the biological activities of hesperidin and hesperetin and their therapeutic effects on diseases. Heliyon. 2024;10(5):e26862. [DOI:10.1016/j.heliyon.2024.e26862] [PMID] [PMCID]
25. Abharian N, Nikray N, Feizi A, Talebi M, Shafaroodi H, Faizi M. The neuroprotective effects of hesperidin and diosmin in neurological disorders via targeting various signaling pathways. Iran J Basic Med Sci. 2025;28(7):825-34.
26. Mosqueda-Solís A, Sánchez J, Portillo MP, Palou A, Picó C. Combination of capsaicin and hesperidin reduces the effectiveness of each compound to decrease the adipocyte size and to induce browning features in adipose tissue of Western diet-fed rats. J Agric Food Chem. 2018;66(37):9679-89. [DOI:10.1021/acs.jafc.8b02611] [PMID]
27. Xiong H, Wang J, Ran Q, Lou G, Peng C, Gan Q, et al. Hesperidin: a therapeutic agent for obesity. Drug Des Devel Ther. 2019;13:3855-66. [DOI:10.2147/DDDT.S227499] [PMID] [PMCID]
28. Prasatthong P, Meephat S, Rattanakanokchai S, Bunbupha S, Prachaney P, Maneesai P, et al. Hesperidin ameliorates signs of the metabolic syndrome and cardiac dysfunction via IRS/Akt/GLUT4 signaling pathway in a rat model of diet-induced metabolic syndrome. Eur J Nutr. 2021;60(2):833-48. [DOI:10.1007/s00394-020-02291-4] [PMID]
29. Shams-Rad S, Mohammadi M, Ramezani-Jolfaie N, Zarei S, Mohsenpour M, Salehi-Abargouei A. Hesperidin supplementation has no effect on blood glucose control: a systematic review and meta-analysis of randomized controlled clinical trials. Br J Clin Pharmacol. 2020;86(1):13-22. [DOI:10.1111/bcp.14120] [PMID]
30. Steinberg GR, Hardie DG. New insights into activation and function of the AMPK. Nat Rev Mol Cell Biol. 2023;24(4):255-72. [DOI:10.1038/s41580-022-00547-x] [PMID]
31. Wu H, Liu Y, Chen X, Zhu D, Ma J, Yan Y, et al. Neohesperidin exerts lipid-regulating effects in vitro and in vivo via fibroblast growth factor 21 and AMP-activated protein kinase/sirtuin type 1/peroxisome proliferator-activated receptor gamma coactivator 1α signaling axis. Pharmacology. 2017;100(3-4):115-26. [DOI:10.1159/000452492] [PMID]
32. Zhang DH, LM, Yu J. Advances in research on the relationship between chronic inflammation and obesity-type hypertension. J Clin Pathol. 2019;39(4):869-73.
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