Wed, Mar 5, 2025
[Archive]
Volume 25, Issue 113 (8-2017)
J Adv Med Biomed Res 2017, 25(113): 13-23 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Damirchi A, Chiti H, Faghihzadeh S, Hakmai Zanjani M. The Effect of Eight Weeks of Combined Aerobic and Resistance Exercise on Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (IGT) and HbA1c in Pre-Diabetic Patients. J Adv Med Biomed Res 2017; 25 (113) :13-23
URL: http://journal.zums.ac.ir/article-1-4790-en.html
URL: http://journal.zums.ac.ir/article-1-4790-en.html
1- Dept. of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran
2- Metabolic Diseases Research Center, Faculty of Medical Sciences, Zanjan University of Medical Sciences, Zanjan
3- Dept. of Biostatistics, Faculty of Medical Sciences, Zanjan University of Medical Sciences, Zanjan
4- Dept. of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran ,mahmoud1ir@yahoo.com
2- Metabolic Diseases Research Center, Faculty of Medical Sciences, Zanjan University of Medical Sciences, Zanjan
3- Dept. of Biostatistics, Faculty of Medical Sciences, Zanjan University of Medical Sciences, Zanjan
4- Dept. of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran ,
Abstract: (157070 Views)
Background and Objective: Lifestyles comprising of physical inactivity coupled with the prevalence of metabolic syndrome and pre-diabetes are the major global public health challenges. Recently, sport sciences have garnered attention as to find new methods for the prevention and treatment of diabetes. Accordingly, the aim of this study is to evaluate the effect of combined exercise on impaired fasting glucose, impaired glucose tolerance and HbA1c in pre-diabetic patients.
Materials and Methods: 30 men with pre-diabetes voluntarily took part in this study and were divided into two groups: pre-diabetes exercise and pre-diabetes control. The pre-diabetes exercise group participated in an aerobic (40 to 70 percent of VO2max) and resistance exercise (50 to 70 percent of 1RM) program for 8 weeks. The control group continued their daily activities and normal life. Changes in the serum levels of fasting glucose, two-hour glucose tolerance and HbA1c were then compared between the groups.
Results: At the end of the study, fasting glucose levels, two-hour glucose tolerance and the percentage of HbA1c were significantly improved in the pre-diabetes exercise group. Fasting glucose levels, two-hour glucose tolerance and the percentage of HbA1c did not decrease in the control group.
Conclusion: Aerobic and resistance exercise are effective on impaired fasting glucose, impaired glucose tolerance and glycosylated hemoglobin A in pre-diabetes patients. This effective method could bring
pre-diabetes patients closer to their therapeutic targets regarding FBS, OGTT and glycosylated hemoglobin A. In this study aerobic and resistance exercise possibly prevent the progression of pre-diabetes and multiple complications of type 2 diabetes. However, further studies are needed to draw firm conclusions.
Keywords: Prediabetes, Hyperglycemia, Impaired Glucose Tolerance, Glycosylated Hemoglobin A, Aerobic and Resistance Exercises
Type of Study: Clinical Trials |
Received: 2017/08/26 | Accepted: 2017/08/26 | Published: 2017/08/26
Received: 2017/08/26 | Accepted: 2017/08/26 | Published: 2017/08/26
References
1. Association. AD. Statistics About Diabetes 2016. Available from:URL: http://www. diabetes.org /diabetes-basics/statistics/.
2. WHO. Global report on diabetes 2016. Available from:URL: http://www.who. int/ diabetes/global-report/en/.
3. Hadaegh F. High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study. BMC Public Health. 2008; 8: 176-83. [DOI:10.1186/1471-2458-8-176] [PMID] [PMCID]
4. Menke AC, Geiss L,Cowie CC. Prevalence of and trendsin diabetes among adults in the United States,1988-2012. JAMA. 2016; 314: 1021-9. [DOI:10.1001/jama.2015.10029] [PMID]
5. GC W. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes. 2004; 53: 16-21. [DOI:10.2337/diabetes.53.suppl_3.S16] [PMID]
6. Faerch K. Pathophysiology and aetiology of impaired fasting glycaemia and impaired glucose tolerance: does it matter for prevention and treatment of type 2 diabetes?. Diabetologia. 2009; 52: 1714-23. [DOI:10.1007/s00125-009-1443-3] [PMID]
7. Organization WH. definition and diagnosis of diabetes mellitus and intermediate hyperglycemi. WHO Document Production Services, Geneva, Switzerland. 2006: 1-200.
8. Dugan JAC. Exercise recommendations for patients with type 2 diabetes. J Am Academ Physic Assist. 2016; 29: 13-8. [DOI:10.1097/01.JAA.0000475460.77476.f6] [PMID]
9. Prevention Cf DCa. National Diabetes Statistics Report. 2015. URL: Available from:https://www.cdc. gov/diabetes/data/ statistics/2014statisticsreport.html
10. Malin SK. Independent and combined effects of exercise training and metformin on insulin sensitivity in individuals with prediabetes. Diabetes Care. 2012; 35: 131-6. [DOI:10.2337/dc11-0925] [PMID] [PMCID]
11. Rowan CP. Aerobic exercise training modalities and prediabetes risk reduction. medicine & science in sports & exercise. Publish Ahead of Print. 2016: 1-30.
12. Lou X. Comparison of the effect of aerobic and resistant exercise on blood glucose in pre-diabetes:. Med Sci Sports Exerc. 2016; 48: 21-31. [DOI:10.1249/01.mss.0000485240.56602.da]
13. Hordern MD. Exercise prescription for patients with type 2 diabetes and pre-diabetes: A position statement from Exercise and Sport Science. Australia J Sci Med Sport. 2012; 15: 25-31. [DOI:10.1016/j.jsams.2011.04.005] [PMID]
14. Hafez A. Physical activity and concentration HbA1C. J Ilam Univ Med Sci. 2013; 21: 35-125.
15. Dan Longo, Dennis Kasper, Stephen Houser.Harrison Principles of Internal Medicine. Endocrine diseases. 2011.
16. Eikenberg JD E. Prediabetes phenotype influences improvements in glucose homeostasis with resistance training.J Pone. 2016; 11. [DOI:10.1371/journal.pone.0148009] [PMID] [PMCID]
17. Basu R. Pathogenesis of prediabetes: role of the liver in isolated fasting hyperglycemia and Combined Fasting and Postprandial Hyperglycemia. J Clin Endocrinol Metab. 2013; 98: 409-17. [DOI:10.1210/jc.2012-3056] [PMID] [PMCID]
18. LJ G. Exercise, glucose transport and insulin sensitivity. Annu Rev Med. 1998; 49: 235-61. [DOI:10.1146/annurev.med.49.1.235] [PMID]
19. Hayley M. O'Neill. AMPK and Exercise: Glucose Uptake and Insulin Sensitivity. Diabetes Metab J. 2013; 37: 1-27. [DOI:10.4093/dmj.2013.37.1.1] [PMID] [PMCID]
20. Richter EA Hargreaves M. Exercise, GLUT, and skeletal muscle glucose uptake. Physiol Rev 2013; 93: 993-1017. [DOI:10.1152/physrev.00038.2012] [PMID]
21. Phillip Tuso .Prediabetes and lifestyle modification:time to prevent a preventable diseas. Perm J. 2014; 18: 88-93. [DOI:10.7812/TPP/14-002] [PMID] [PMCID]
22. Gaeni A. ACSM Guidelines for Exercise Testing and Prescription. Hatmi publications. 2015-235-245
23. Sadeghi Pour HR, Daryanoosh F, Salesi M. The effect of aerobic exercise on serum concentrations chemerin twelve weeks, vaspin index and insulin resistance in overweight students. J Zanjan Univ Med Sci. 2016; 98: 52-60.
24. Chiti H, Shakibi E, Soltani Z, Mazloomzadeh S, Mousavinasab S. Prevalence of metabolic syndrome and cardiovascular risk factors among physicians of Zanjan City. J Zanjan Univ Med Sci. 2016; 24: 10-20
25. Daryanoosh F, Aminilari Z. The effect of 12 weeks of resistance training on the Apelin, Omentin-1 levels and insulin resistance in the elderly overweight women with type 2 diabetes. J Zanjan Univ Med Sci. 2015; 23: 29-40
26. Fadaii Chaffee MR. Rahmani-Nia F, Mohebi H, et al. Effect of aerobic exercise on insulin resistance index and body composition in obese boys during puberty. J Apply Sport Physiol. 2016; 23: 29-42.
27. Mehrabani J, Damirchi A. Rahmani-Nia F. The effect of aerobic exercise intensity levels of lipocalin - 2, IL - 1 beta and insulin resistance index in obese sedentary men. Exercise Physiol. 2014; 21: 95-108.
28. Heidari S, Rezaei M, Sajadi M, Ajorpaz NM, Koenig HG. Religious practices and self-care in iranian patients with type 2 diabetes. J Religion Health. 2016; 25: 10-20. [DOI:10.1007/s10943-016-0320-x] [PMID]
29. Hordern MD, Dunstan DW, Prins JB, Baker MK, Singh MA, Coombes JS. Exercise prescription for patients with type 2 diabetes and pre-diabetes: a position statement from exercise and sport science australia. J Sci Med Sport. 2012; 15: 25-31. [DOI:10.1016/j.jsams.2011.04.005] [PMID]
30. Alibegovic AC. Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men. Am J Physiol Endocrinol Metab. 2010; 5: 752-63. [DOI:10.1152/ajpendo.00590.2009] [PMID]
31. Gong QH KJ, Ying YY, Li H, Zhang XH, Wu YH, Xu GZ. Lifestyle interventions for adults with impaired glucose tolerance: a systematic review and meta-analysis of the effects on glycemic control. Intern Med. 2015; 54: 302-10. [DOI:10.2169/internalmedicine.54.2745] [PMID]
32. Mary E Jung. High-intensity interval training as an efficacious alternative to moderate-intensity continuous training for adults with prediabetes. J Diabetes Res. 2015; 2015: 1-9. [DOI:10.1155/2015/191595] [PMID] [PMCID]
33. Tadibi V. Compare the effect of eight weeks aerobic exercise combined with leptin and glucose levels in men with type 2 diabetes. J Med Sci. 2015; 1: 10-7.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Copyright Policy
