شنبه 24 خرداد 1404
[Archive]
دوره 19، شماره 74 - ( 1-1390 )
جلد 19 شماره 74 صفحات 77-63 |
برگشت به فهرست نسخه ها
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Hamta A, SHariatzadeh S M A, Soleimani M, Seifi F. Introduction and Bioinformatic's Evaluation of Candidate Genes in Breast Cancer Using Cytogenetic Studies of Cancer Induction. J Adv Med Biomed Res 2011; 19 (74) :63-77
URL: http://journal.zums.ac.ir/article-1-1418-fa.html
URL: http://journal.zums.ac.ir/article-1-1418-fa.html
همتا احمد، شریعت زاده سید محمد علی، سلیمانی مهرنجانی ملک، سیفی فاطمه. معرفی و بررسی بیوانفورماتیکی ژن‌های کاندید در بروز سرطان پستان به روش مطالعه‌ی سیتوژنتیکی سرطان القایی. Journal of Advances in Medical and Biomedical Research. 1390; 19 (74) :63-77
1- دکترای تخصصی ژنتیک مولکولی و سیتوژنتیک، استادیار دانشگاه اراک ، a-hamta@araku.ac.ir
2- دکترای تخصصی جنین‌شناسی و بافت‌شناسی، استاد دانشگاه اراک
3- دکترای تخصصی جنین‌شناسی و بافت‌شناسی، دانشیار دانشگاه اراک
4- کارشناس ارشد سلولی تکوینی، دانشگاه اراک
2- دکترای تخصصی جنین‌شناسی و بافت‌شناسی، استاد دانشگاه اراک
3- دکترای تخصصی جنین‌شناسی و بافت‌شناسی، دانشیار دانشگاه اراک
4- کارشناس ارشد سلولی تکوینی، دانشگاه اراک
چکیده: (176052 مشاهده)
Background and Objective: Discovery of genetic changes which contribute to cellular neoplastic and malignant tumor transformation is one of the major aims in oncology researches. The aim of this study was to investigate the DMBA-induced breast cancer in SD rat strains using bioinformatical methods and also to find their homologous regions in human chromosomes. Materials and Methods: In this research, we used SD rat strains as a suitable model for DMBA-induced breast cancer. We gavaged the rats twice with 10 mg DMBA solved in 0.5 ml sesame oil. After tumors appeared in DMBA-treated rats, they were subjected to histopathology and immunohistochemistery studies, cell culture, metaphase chromosomal preparation, and finally G-banding stain. According to databases, we collected genes in the affected area and prepared a gene list by comparing genome of the rats and human in changed chromosomal segments. Results: Our data showed numerical and frequent structural changes in different number of chromosomes. For example, we found recurrent gain in chromosomes 3, 4, 8, 12, 17, loss in chromosomes 3, 9, 12 and 15, also deletion in chromosomes 2, 3, 4, 6, 7, 20 and addition in chromosomes 11, 15 and 19. Conclusion: According to these chromosomal changes and based on bioinformatics studies we predict that the genesTGFBR3, HACE1, UBR5, CALB2, HPR, LCP1, RRM2B, ABO, ZFHX3, TNFSF11, ABL1, EPSTI1, PRDM1, REG3A, FOXA1 and PRKD1, probably may contribute to the development of breast cancer.
نوع مطالعه: مقاله پژوهشی |
دریافت: 1389/12/17 | پذیرش: 1393/4/2 | انتشار: 1393/4/2
دریافت: 1389/12/17 | پذیرش: 1393/4/2 | انتشار: 1393/4/2
فهرست منابع
1. Calasanz MJ, Cigudosa JC. Molecular cytogenetics in translational oncology: when chromosomes meet genomics. Clin Transl Oncol. 2008; 10: 20-29. [DOI:10.1007/s12094-008-0149-1] [PMID]
2. American Cancer Society. Breast cancer facts & figures. Atlanta, American Cancer Society Inc. 2007-2008.
3. Center of management of noncontiguous diseases. IRAN Ministry of Health and Medical Education. [Cancer Registry Report]. 2004: 20-55.
4. Miyata M, Furukawa M, Takahashi K, Gonzalez FJ, Yamazoe Y. Mechanism of 7, 12-dimethylbenz [a] anthracene-induced immunotoxicity: Role of metabolic activation at the target organ. Jpn J Pharmacol. 2001; 63: 302-9. [DOI:10.1254/jjp.86.302] [PMID]
5. Ueda M, Takagi H, Onodera H, et al. Enhancing effects of beta-estradiol 3-benzoate but not methoxychlor on the promotion/progression stage of chemically-induced mammary carcinogenesis in ovariectomized rats. Jpn J Cancer Res. 2002; 93: 752-9. [DOI:10.1111/j.1349-7006.2002.tb01316.x] [PMID] [PMCID]
6. Ciocca DR, Vargas Roig LM. Estrogen reseptors in human nontarget tissues: Biological and clinical implications. Endocrine Reviews. 1995; 16: 35. [DOI:10.1210/edrv-16-1-35] [PMID]
7. Ogle TF, Dai D, George P, Mahesh VB. Stromal cell progesterone and estrogen reseptors during proliferation and regression of the decidua basalis in the pregnant rat. Biol Reprod. 1997; 57: 495-506. [DOI:10.1095/biolreprod57.3.495] [PMID]
8. Ma DF, Katoh R, Zhou H, Wang PY. Promoting effects of milk on the development of 7, 12-dimethylbenz (a) anthracene (DMBA)-induced mammary tumors in rats. Acta Histochem Cytochem. 2007; 40: 61-7. [DOI:10.1267/ahc.07008] [PMID] [PMCID]
9. Hall PA, Levison DA, Woods AL, et al. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol. 1990; 162: 285-94. [DOI:10.1002/path.1711620403] [PMID]
10. Vonlanthen S, Kawecki TJ, Betticher DC, Pfefferli M, Schwaller B. Heterozygosity of SNP513 in intron 9 of the human calretinin gene (CALB2) is a risk factor for colon cancer. Anticancer Res. 2007; 27: 79-88.
11. Shurbaji MS, Pasternack GR, Kuhajda FP. Expression of haptoglobin-related protein in primary and metastatic breast cancers. A longitudinal study of 48 fatal tumors. Am J Clin Pathol. 1991; 96: 238-42. [DOI:10.1093/ajcp/96.2.238] [PMID]
12. Zhang Z, Yamashita H, Toyama T, et al. ATBF1-a messenger RNA expression is correlated with better prognosis in breast cancer. Clin Cancer Res. 2005; 11: 191-8.
13. Cho Y, Song JH, Kim CJ, et al. Genetic alterations of the ATBF1 gene in gastric cancer. Clin Cancer Res. 2007; 13: 4355-9. [DOI:10.1158/1078-0432.CCR-07-0619] [PMID]
14. Dong M, How T, Kirkbride KC, et al. The type III TGF-beta receptor suppresses breast cancer progression. J Clin Invest. 2007; 117: 206-17. [DOI:10.1172/JCI29293] [PMID] [PMCID]
15. Orntoft TF, Meldgaard P, Pedersen B, Wolf H. The blood group ABO gene transcript is down-regulated in human bladder tumors and growth-stimulated urothelial cell lines. Cancer Res. 1996; 56: 1031-36.
16. Gao S, Worm J, Guldberg P, et al. Genetic and epigenetic alterations of the blood group ABO gene in oral squamous cell carcinoma. Int J Cancer. 2004; 109: 230-7. [DOI:10.1002/ijc.11592] [PMID]
17. Srinivasan D, Sims JT, Plattner R. Aggressive breast cancer cells are dependent on activated Abl kinases for proliferation, anchorage-independent growth and survival. Oncogene. 2008; 27: 1095-105. [DOI:10.1038/sj.onc.1210714] [PMID]
18. Davoodpour P, Landström M, Welsh M. Reduced tumor growth in vivo and increased c-Abl activity in PC3 prostate cancer cells overexpressing the Shb adapter protein. BMC Cancer. 2007; 7: 61-5. [DOI:10.1186/1471-2407-7-161] [PMID] [PMCID]
19. Yanagawa T, Harada H, Iwasa S, et al. c-Abl expression in oral squamous cell carcinomas. Oral Oncol. 2000; 36: 89-94. [DOI:10.1016/S1368-8375(99)00067-6]
20. Park HR, Min SK, Cho HD, Kim DH, Shin HS, Park YE. Expression of osteoprotegerin and RANK ligand in breast cancer bone metastasis. J Korean Med Sci. 2003; 18: 541-6. [DOI:10.3346/jkms.2003.18.4.541] [PMID] [PMCID]
21. Chen. G. Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation. J Korean Med Sci. 2006; 107: 289-98. [DOI:10.1002/cncr.21978] [PMID]
22. Nielsen HL, Ronnov-Jessen L, Villadsen R., Petersen OW. Identification of EPSTI1, a novel gene induced by epithelial-stromal interaction in human breast cancer. Genomics. 2002; 79: 703-10. [DOI:10.1006/geno.2002.6755] [PMID]
23. Foran E, McWilliam P, Kelleher D, Croke DT, Long A. The leukocyte protein L-plastin induces proliferation, invasion and loss of E-cadherin expression in colon cancer cells. Int J Cancer. 2006; 118: 2098-104. [DOI:10.1002/ijc.21593] [PMID]
24. Chung I, Schwartz PE, Crystal RG, Pizzorno G, Leavitt J, Deisseroth AB. Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells. Cancer Gene Ther. 1999; 6: 99-106. [DOI:10.1038/sj.cgt.7700017] [PMID]
25. Klemke M, Rafael MT, Wabnitz GH, et al. Phosphorylation of ectopically expressed L-plastin enhances invasiveness of human melanoma cells. Int J Cancer. 2007; 120: 2590-9. [DOI:10.1002/ijc.22589] [PMID]
26. Choi B, Suh Y, Kim WH, Christa L, Park J, Bae CD. Downregulation of regenerating islet-derived 3 alpha (REG3A) in primary human gastric adenocarcinomas. Exp Mol Med. 2007; 39: 796-804. [DOI:10.1038/emm.2007.86] [PMID]
27. Zhang L, Anglesio MS, O'Sullivan M, et al. The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med. 2007; 13: 1060-9. [DOI:10.1038/nm1621] [PMID]
28. Pasqualucci L, Compagno M, Houldsworth J, et al. Shipp MA, Dalla-Favera R. Inactivation of the PRDM/١BLIMP1 gene in diffuse large B cell lymphoma. J Exp Med. 2006; 203: 311-7. [DOI:10.1084/jem.20052204] [PMID] [PMCID]
29. Jaggi M, Rao PS, Smith DJ, Hemstreet GP, Balaji KC. Protein kinase C mu is down-regulated in androgen-independent prostate cancer. Biochem Biophys Res Commun. 2003; 307: 254-60. [DOI:10.1016/S0006-291X(03)01161-6]
30. Lee HJ, Hwang M, Chattopadhyay S, Choi HS, Lee K. Hepatocyte nuclear factor-3 alpha (HNF-3alpha) negatively regulates androgen receptor transactivation in prostate cancer cells. Biochem Biophys Res Commun. 2008; 367: 481-6. [DOI:10.1016/j.bbrc.2007.12.162] [PMID]
31. Liu X. Metastasis-suppressing potential of ribonucleotide reductase small subunit p53R2 in human cancer cells. Clin Cancer Res. 2006; 12: 6337-44. [DOI:10.1158/1078-0432.CCR-06-0799] [PMID]
32. Clancy JL, Henderson MJ, Russell AJ, et al. The human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in breast and ovarian cancer. Oncogene. 2003; 22: 5070-81. [DOI:10.1038/sj.onc.1206775] [PMID]
ارسال پیام به نویسنده مسئول
| بازنشر اطلاعات | |
 |
این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است. |
