جمعه 16 خرداد 1404
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دوره 19، شماره 75 - ( 2-1390 )
جلد 19 شماره 75 صفحات 10-1 |
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Nazem H, Sharifi F, Kazemi S A N, Mousavinasab S N, Ghorovghi N, Boayni S et al . Association of Cord Blood Resistin with Leptin, Insulin, Growth Indices and Fat Levels in Neonates of Mousavi Hospital of Zanjan in 2009. J Adv Med Biomed Res 2011; 19 (75) :1-10
URL: http://journal.zums.ac.ir/article-1-1486-fa.html
URL: http://journal.zums.ac.ir/article-1-1486-fa.html
ناظم حبیب، شریفی فرانک، کاظمی سید‌علی‌نقی، موسوی نسب سیدنورالدین، غرقی نصرالله، بوئینی ثریا و همکاران.. بررسی ارتباط رزیستین بند ناف با لپتین، انسولین، اندکس‌های رشدی و درصد چربی نوزادان تازه متولد شده در بیمارستان آیت الله موسوی زنجان در سال1388. Journal of Advances in Medical and Biomedical Research. 1390; 19 (75) :1-10
حبیب ناظم1 
، فرانک شریفی2 ، سید‌علی‌نقی کاظمی3 ، سیدنورالدین موسوی نسب4 ، نصرالله غرقی5 ، ثریا بوئینی6 ، علی‌اوسط ملتی*7
، فرانک شریفی2 ، سید‌علی‌نقی کاظمی3 ، سیدنورالدین موسوی نسب4 ، نصرالله غرقی5 ، ثریا بوئینی6 ، علی‌اوسط ملتی*7
1- دکترای بیوشیمی بالینی، دانشیار دانشگاه پیام نور مرکز تهران
2- فوق تخصص غدد، مرکز تحقیقات بیماری‌های متابولیک زنجان، استاد دانشگاه علوم پزشکی زنجان
3- متخصص اطفال، مرکز تحقیقات بیماری‌های متابولیک زنجان، دانشیار دانشگاه علوم پزشکی زنجان
4- دکترای تخصصی آمار زیستی، مرکز تحقیقات بیماری‌های متابولیک زنجان، دانشیار دانشگاه علوم پزشکی زنجان
5- کارشناسی ارشد بیوشیمی، دانشگاه پیام نور مرکز تهران
6- کارشناس ارشد ایمونولوژی، بیمارستان حضرت ولیعصر(عج) زنجان
7- دکترای بیوشیمی، مرکز تحقیقات بیماری‌های متابولیک زنجان، دانشیار دانشگاه علوم پزشکی زنجان ،mellati3000@yahoo.com
2- فوق تخصص غدد، مرکز تحقیقات بیماری‌های متابولیک زنجان، استاد دانشگاه علوم پزشکی زنجان
3- متخصص اطفال، مرکز تحقیقات بیماری‌های متابولیک زنجان، دانشیار دانشگاه علوم پزشکی زنجان
4- دکترای تخصصی آمار زیستی، مرکز تحقیقات بیماری‌های متابولیک زنجان، دانشیار دانشگاه علوم پزشکی زنجان
5- کارشناسی ارشد بیوشیمی، دانشگاه پیام نور مرکز تهران
6- کارشناس ارشد ایمونولوژی، بیمارستان حضرت ولیعصر(عج) زنجان
7- دکترای بیوشیمی، مرکز تحقیقات بیماری‌های متابولیک زنجان، دانشیار دانشگاه علوم پزشکی زنجان ،
چکیده: (181954 مشاهده)
Background and Objective: Resistin is a novel adipokine which may play a role in insulin resistance. In this study we aimed to determine the cord blood resistin, leptin, insulin and maternal serum resistin levels during pregnancy; and to investigate correlation between these metabolic hormones; and also to evaluate their association with newborn growth indices.
Materials and Methods: This study was conducted on 80 newborns and their mothers in Mousavi Hospital Zanjan, Iran in 2009. Newborn growth indices including birth weight, height, body mass index (BMI), Ponderal index, Homeostatic Model assessment (HOMA-IR) and their mothers’ BMI were determined. Resistin, leptin and insulin levels were measured by ELISA.
Results: In this study, cord blood resistin levels were higher than serum resistin levels of pregnant mothers (10.77±1.53 vs. 7.91± 5.71 ng/ml). Moreover, serum resistin levels of mothers’ did not exhibit any correlation with cord blood resistin, leptin and insulin levels, as well as neonatal anthropometric indices. Meanwhile, there was no significant correlation between cord resistin levels, insulin resistance, fat percentage and newborn growth factors. Cord resistin levels were positively correlated with cord blood leptin levels (r=0.222; p=0.048). Also, there was a significant positive correlation between cord blood leptin and neonatal BMI (r=0.223; p=0.047), Ponderal index (r=0.212; p=0.058), HOMA-IR (r=0.426; p=0.052) and fat percentage (r=0.247; p=0.014).
Conclusion: On the basis of the findings, increased cord blood resistin levels may indirectly influence fetal growth through leptin or other cytokine levels. Though, further researches are needed to confirm this matter.
نوع مطالعه: مقاله پژوهشی |
دریافت: 1390/3/18 | پذیرش: 1393/4/1 | انتشار: 1393/4/1
دریافت: 1390/3/18 | پذیرش: 1393/4/1 | انتشار: 1393/4/1
فهرست منابع
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