دوره 19، شماره 77 - ( 4-1390 )                   جلد 19 شماره 77 صفحات 8-1 | برگشت به فهرست نسخه ها

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Sharifi F, Pirani S, Gholami H. The Relationship Between Serum Zinc Concentration and Short Stature in Adolescents Younger than Age 15y. J Adv Med Biomed Res 2011; 19 (77) :1-8
URL: http://journal.zums.ac.ir/article-1-1652-fa.html
شریفی فرانک، پیرانی سولماز، غلامی حسین. بررسی رابطه‌ی سطح سرمی روی با کوتاهی قد در کودکان زیر 15 سال زنجان. Journal of Advances in Medical and Biomedical Research. 1390; 19 (77) :1-8

URL: http://journal.zums.ac.ir/article-1-1652-fa.html


1- ، sol_0001@yahoo.com
چکیده:   (168173 مشاهده)

Background and Objective: Linear growth is one of the most important criteria of general public health. As a micronutrient, zinc is known to affect linear growth. Considering the low prevalence of zinc deficiency in Zanjan, analysis of the impact of zinc deficiency in children with short stature in this province could provide valuable information. The aim of this study was to compare the serum concentration of Zinc in children with short stature and those with normal growth in Zanjan.
Materials and Methods: This case–control study was conducted on two groups of school children under the age of 15, including 50 subjects with short stature, who were randomly selected from the patients of endocrine clinic of Vali-e-asr general hospital, and 50 normal-growth children. Normal subjects were selected from the cases classmates with the same socioeconomic situation. After collection of general health data and anthropometric measurements, blood samples were taken to detect serum concentrations of zinc in all of the participants.
Results: One hundred children, including 50 males and 50 females, with a mean age of 10.2±3 years were investigated. Serum concentrations of zinc were significantly lower in the subjects with short stature (94±23.1 µg/dl vs. 110.9±12.4 µg/dl in normal subjects; p: 0.001).  A significant positive correlation was found between serum concentrations of zinc and the height of the subjects in both groups (r: 0.2, p: 0.02).
Conclusion: There is a positive correlation between serum zinc concentration and the height of the children even in the zinc sufficient areas like Zanjan. Future studies for analysis of the impact of zinc supplementation on the growth velocity of subjects with zinc deficiency are recommended.

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نوع مطالعه: مقاله پژوهشی |
دریافت: 1390/8/26 | پذیرش: 1393/4/1 | انتشار: 1393/4/1

فهرست منابع
1. Nishi G, hatano S, Aihara K, et al. Transeint partial growth homon defficencity due to Zinc deficiency. J Am Coll Nutr. 1989: 8: 93-7. [DOI:10.1080/07315724.1989.10720283] [PMID]
2. Black RE. Therapeutic and preventive effects of zinc on serious children infectious diseases in developing countries. Am J clin Nutr. 1998; 68: 476-9. [DOI:10.1093/ajcn/68.2.476S] [PMID]
3. sharifi F, hedayati M, Mirmiran P, Mehrabi Y, Azizi F. Serum zinc, copper and iron levels in schoolchildren in 23 provinces of iran; 1996. Iranian J Endocrinol Metab. 2000; 1: 275-85.
4. Michaelsen kf, Samuelson G, Graham TW. Zinc intake, zinc status and growth in a longitudinal study of healthy Danish infants. Acta Pediatr. 1994; 83: 1115-21. [DOI:10.1111/j.1651-2227.1994.tb18262.x] [PMID]
5. Bhaskaram P, Hemalaltha P. Zinc status of Indian children. Indian J Med Res. 1995; 102: 210-5.
6. Kalantari N. Care and treatment of severe malnutrition, world health organization. Tehran: Tehran agricultural sciences publication; 1999.
7. Kimiagar M, Mahmodi MR, Valaee N, Gafarpor M. An epidemiologic study of zinc deficiency in junior school students in Tehran; [Dissertation]. Tehran: Food industry research institute of nutrition; 1997.
8. Van wouwe JP, de wolff FA, Van Gelderen HH. Zinc in hair and urine of paediatric patients. Clin Chim Acta. 1986; 155: 77-82. [DOI:10.1016/0009-8981(86)90101-4]
9. Maggini S, Wenzlaff S, Hornig D. Essentical role of vitamin C and zinc in child immunity and health. J Int Med Res. 2010; 38: 386-414. [DOI:10.1177/147323001003800203] [PMID]
10. Wintergerst ES, Maggini S, Hornig DH.Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab. 2007; 51: 301-23. [DOI:10.1159/000107673] [PMID]
11. Nishi Y. Zinc and growth. J Am Coll Nutr. 1996; 15: 340-4. [DOI:10.1080/07315724.1996.10718608] [PMID]
12. Hakimi SM, Hashemi F, Valaeei N, Seyed-Masood K, Velayati AA, Boloursaz MR. The effect of supplemental zinc on the height and weight percentiles of children. J Grace. 1999; 3: 1-9.
13. Sayeg MA, Oliveira HP, Cunha A, et al. Linear growth and zinc supplementation in children with short stature. J Pediatr Endocrinol Metab. 2000; 13: 1121-8. [DOI:10.1515/JPEM.2000.13.8.1121] [PMID]
14. Imamoglu S, Bereket A, Turan S, Taga Y, Haklar G. Effect of zinc supplementation on growth hormone secretion, IGF, IGF BP-3, somatomedin generation, alkalin phosphatase, osteocalcin and growth in prepubertal children with idiopatic short stature. J Pediatr Endocrinol Metab. 2005; 18: 69-74. [DOI:10.1515/JPEM.2005.18.1.69] [PMID]
15. Siklar Z, Tuna C, Dallar Y, Tanyer G. Zinc deficienty: a contributing factor of short stature in growth hormone deficient children. J Trop pediatr. 2003; 49: 187-8. [DOI:10.1093/tropej/49.3.187] [PMID]
16. Mozaffari-Khosravi H, Shakiba M, Eftekhari MH, Fatehi F. Effects of zinc supplementation on physical growth in 2-5 year-old children. Biol Trace Elem Res. 2009; 128: 118-27. [DOI:10.1007/s12011-008-8261-1] [PMID]
17. Brown KH, person JM, Allen LH. Effect of zinc supplementation on children growth: a meta-analysis of intervention trials. Biol Nutr Dieta. 1998; 54: 76-83. [DOI:10.1159/000059448] [PMID]
18. Nakamura T, Nishiyama S, Futagoishi Y, Matsuda I, Higashi A. Mild to moderate zinc deficiency in short children: effect of zinc supplementation on Linear growth velocity. J Pediatr. 1993; 123: 65-9 . [DOI:10.1016/S0022-3476(05)81538-0]
19. Rosado JL, Lopez P, Munoz E, Martinez H, Allen LH. Zinc supplementation reduced morbidity, but neither zinc nor iron supplemention affected growth or body compsition of Mexican preschoolers. Am J Clin Nut. 1997; 65: 13-9. [DOI:10.1093/ajcn/65.1.13] [PMID]
20. Friis H, Ndhlovu P, Mduluza T, et al. The impact of zinc supplementation on growth and body composition: A randomized, controlled trial among rural Zimbabwean school children. Eur J Clin Nut. 1997; 51: 38-45. [DOI:10.1038/sj.ejcn.1600358] [PMID]
21. kilic J, Ozalp I, Coskun T, et al. Tokatli A, Emre S, Saldamli L, Koksel H, Ozboy O. The effect of zinc-supplemented - bread consumption on school children with asymptomatic zinc deficiency. J Pediatr Gastroenterol Nut. 1998; 26: 167-71. [DOI:10.1097/00005176-199802000-00008] [PMID]
22. Sazawal S, Dhingra U, Dhingra P, et al. Micronutrient fortified milk improves iron stature, anemia and growth among children 1-4 years: a doble masked, randomized, controlled trial. P LoS One. 2010; 5: e12167. [DOI:10.1371/journal.pone.0012167] [PMID] [PMCID]
23. Hambidge M. Human zinc deficiency. J Nutrition. 2000; 130: 1344S-9S. [DOI:10.1093/jn/130.5.1344S] [PMID]

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