Background and Objective: Mental health and self- esteem are psychological issues that have long been considered by psychologists, physicians and religious scholars and have also been influenced by a set of social and cognitive factors. The purpose of this study was to investigate the effect of training communication skills adopting a religious approach on self- esteem and mental health of male students. Materials and Methods: The research method was experimental using pre-test, post-test design with a control group. The instruments included the Cooper Smith Self-esteem Questionnaire (1986) and Goldberg General Health Questionnaire (1988). The population of the research included all high school male students in Zanjan in the school year of 2011-2012. Out of this population, 60 students were randomly selected by multi-stage- cluster sampling method and were then divided into two experimental and control groups. Intervention (communicative skills improving through a religious approach) was carried out on the experimental group for fifteen sessions, each lasting for ninety minutes and once a week. SPSS 14 and Ancova tests were used to analyze the collected data. Results: The results of Ancova showed that there was a significant difference in the means of the experimental and control groups in terms of self-esteem (F=44.64, P<0.001) and mental health (F=85, P<0.001). Conclusion: The communication skills training by using a religious approach was effective in the improvement of self-esteem and mental health of students.