Background and Objective: salvia officinalis L. consists of, glycosides, flavonoids, and anthocyanins. Due to the increasing use of medicinal plants in treatment of diseases and their side effects on various organs, this study was conducted to evaluate the effect of salvia officinalis on biochemical blood parameters in male rats. Materials and Methods: In this experimental study, 24 male Wistar rats were randomly assigned to four groups of 6 animals each. The control group received normal saline and treatment groups received 75, 150 and 300 mg/kg body weight of salvia extract for 14 days. Body weight was measured in days 0, 7, and 14. At the end of the experiment, serum levels of liver function enzymes such as AST and ALT, total proteins, albumin, creatinine, cholesterol and triglyceride were assessed. Results were analyzed using one- way ANOVA and Tukey test. 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