جمعه 16 خرداد 1404
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دوره 11، شماره 42 - ( فروردين 1382 )
جلد 11 شماره 42 صفحات 15-9 |
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Shariati M, Parivar K, Oryan S, Shokravi A, Alizadeh R. The Effect Of A New Phenanthroline Derivative On Serum Testosterone Level And Its Contraceptive Effects On Adult Balb/C Mouse Strain. J Adv Med Biomed Res 2003; 11 (42) :9-15
URL: http://journal.zums.ac.ir/article-1-30-fa.html
URL: http://journal.zums.ac.ir/article-1-30-fa.html
شریعتی مهرداد، پریور کاظم، عریان شهربانو، شکروی عباس، علی زاده ربابه. تاثیر ترکیب جدیدی از فنانترولین بر میزان تستوسترون و اثرات ضد باروری آن در موش های نر بالغ نژاد Balb/C. Journal of Advances in Medical and Biomedical Research. 1382; 11 (42) :9-15
چکیده: (160043 مشاهده)
Background: Due to the problems arising from the overpopulation, attention has been focused on contraceptives for men. Phenanthrolines are a group of organic compounds with ionophilic characteristics and a wide range of use in biology and chemistry. In this study the effect of 2,6-diaminopyridinum was studied on hypophysis-gonad axis, testicular tissue and sperm production in male Balb/c mice.
Materials and Methods: Fifty adult male Balb/C mice were divided in 5 groups. First group was used as untreated control. Saline was injected to the 2nd group and the remaining 3 groups were received intraperitoneal injection of 15, 20 and 25 mg/kg of 2,6-diaminopyridinum every other day for 20 days. The LD50 was determined to be 35 mg/kg body weight. The serum concentrations of FSH, LH and testosterone were measured and the testicular tissues were studied morphologically.
Results: The data showed that 25 mg/kg diaminopyridinum decreased the serum testosterone level significantly with no changes on FSH and LH levels. Histological studies on testicular tissue showed a significantly lower numbers of germ cells.
Conclusion: The data obtained in this study indicate that 25 mg/kg of phenanthroline may directly affect testicular tissue causing a lower testosterone level and spermatogenesis in mice.
Materials and Methods: Fifty adult male Balb/C mice were divided in 5 groups. First group was used as untreated control. Saline was injected to the 2nd group and the remaining 3 groups were received intraperitoneal injection of 15, 20 and 25 mg/kg of 2,6-diaminopyridinum every other day for 20 days. The LD50 was determined to be 35 mg/kg body weight. The serum concentrations of FSH, LH and testosterone were measured and the testicular tissues were studied morphologically.
Results: The data showed that 25 mg/kg diaminopyridinum decreased the serum testosterone level significantly with no changes on FSH and LH levels. Histological studies on testicular tissue showed a significantly lower numbers of germ cells.
Conclusion: The data obtained in this study indicate that 25 mg/kg of phenanthroline may directly affect testicular tissue causing a lower testosterone level and spermatogenesis in mice.
نوع مطالعه: مقاله پژوهشی |
دریافت: 1385/6/15 | پذیرش: 1396/3/28 | انتشار: 1396/3/28
دریافت: 1385/6/15 | پذیرش: 1396/3/28 | انتشار: 1396/3/28
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