Background and Objective: Previous studies indicate an inverse association of serum 25-hydroxyvitamin-D level with obesity, metabolic syndrome and cardiovascular events. This study was aimed to assess metabolic syndrome correlation with serum Vit-D levels of physicians in Zanjan city (Iran). Materials and Methods: In an analytical cross-sectional study, a total of 108 physicians were selected and their 25-hydroxyvitamin D status, fasting blood glucose, triglyceride and HDL were assessed using venous blood. Metabolic syndrome was defined based on ATPIII criteria. Data was analyzed using SPSS software. Results: The mean serum 25(OH) D concentration was 23.40±23.72 ng/ml and its median level was 17.65 ng/ml. 25 (OH) D concentrations <20 ng/ml was observed in 62% of the participants. The prevalence of Metabolic Syndrome for the whole sample was 21.2%. The most prevalent components of metabolic syndrome were hypertriglyceridemia and low HDL with a prevalence of 55.6% and 38%, respectively. Significant correlative difference was found between serum 25(OH) D levels and triglyceride (P = 0.009). Conclusion: The prevalence of vitamin D deficiency and metabolic syndrome among physicians in Zanjan was lower than general population. A significant association between serum levels of Vitamin D and triglyceride was detected, which may be due to higher BMI. References 1- Hoseinnejad A, Maghbuli ZH, Mirzaie KH, Karimi F, Larijani B. Relation of vitamin D3 level with metabolic syndrome among Iranian adult populations. Iran J Diabetes Lipid. 2009 9: 383-9. 2- Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. executive summary of the third report of the national cholesterol education program (NCEP) JAMA. 2001 285-97. 3- Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nut. 2004 79: 820-5. 4- Bonakdaran S, Varasteh A, Khajeh-Dalouie M. Serum 25 hydroxy vitamin D3 and laboratory risk markers of cardiovascular diseases in type 2 diabetic patients. Iran J Endocrin Metab. 2010 504-9. 5- Chagas C, Borges M, Rogero L. Focus on vitamin D, inflammation and type 2 diabetes. J Nutrients. 2012 4: 52-67. 6- Tohru Funahashi,Yuji Matsuzawa, Shinji Kihara. Adiponectin as a potential key player in metabolic syndrome insights into atherosclerosis, diabetes and cancer. International Congress Series1262 2004 368-71 7- Wang C, Pereira R, Hosoka P, et al. Association between 25-hydroxyvitamin D and adiponectin levels in hypertensive subjects. Eur J Endocrinol. 2011 164: 995-1002. 8- Chacko S, Song Y, Manson J, et al. Serum 25-hydroxyvitamin D concentrations in relation to cardiometabolic risk factors and metabolic syndrome in postmenopausal women. The Am J Clin Nut. 2011 94 209-17. 9- Ziaee A, Hashemipoor S, Karimzadeh T, Jalalpoor A, Javadi A. Relation of vitamin D3 Serum level with metabolic syndrome indices among patients with diabetes and non-diabetic individuals. J Ardabil Univ Med Sci. 2012 12: 149-56. 10- Yilmaz H, Kaya M, Sahin M, Delibasi T. Is vitamin D status a predictor glycaemic regulation and cardiac complication in type 2 diabetes mellitus patients?. J Diabetes Metab Clin Res Rev. 2012 253: 350-4. 11- Sharifi F, Mousavinasab N, Saeini M, Dinmohammadi M. Prevalence of metabolic syndrome in an adult urban population of the west of iran. Expert Diabetes Res. 2009 140-5. 12- Hurskainen AR, Virtanen JK, Tuomainen TP, Nurmi T, Voutilainen S. Association of serum 25-hydroxyvitamin D with type 2 diabetes and markers of insulin resistance in a general older population in Finland. J Diabetes Metab Res Rev. 2012 28 418-23. 13- Park HY, Lim YH, Kim JH, Bae S, Oh SY, Hong YC. Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly: a repeated measure analysis.journal of Korean medical science. 2012 27 653-660. 14- Ford E, Ajani U, Mcguire L, Liu S. Concentrations of serum vitamin d and the metabolic syndrome among U.S. adults. J Diabetes care. 2005 28 1228-30. 15- Salekzamani S, Neyestani TR, Alavi-Majd H, et al. Is vitamin D status a determining factor for metabolic syndrome? J Diabetes Metab Obes. 2011 4 205-12.