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Background: Methoxsalon is considered as an effective drug in controlling skin diseases. Since there have been reports concerning cellular disorders following the intake of the drug, this study was undertaken to analyze the effects of methoxsalon treatment on liver in subjects in Tehran Medical university (2003-2004). Materials and Methods: In this experimental study 40 albino rabbits (32 females & 8 males) with approximate weight of 2.5-3 Kg and 5.5-6 months old were divided into 4 groups. One group served as control and 3 others as treatment groups to investigate the effects of the drug in three different stages of pregnancy (predifferentiation stage, embryonic stage and fetal stage) . Following the copulation and successful fertilization, an oral dose of 0.6 mg/kg drug was administered to treatment groups every other day for 8 days. Fourteen weeks after birth, prenatal treated rabbits were anesthetized and were submited to light microscopic tissue preparation. Results: Hypertrophic hepatocytes with highly vaceuolated cytoplasm and degenerated nuclei were found. Conclusion: Regarding the vital importance of proper functioning of hepatocytes either during fetal stage or adulthood and in the light of harmful effects of methaxosalon on fetus, it is recommended that administration of the drug be carefully carried out. More research is also recommended.

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