Introduction: Regarding the side effects of muscle relaxants especially non - depolarizing agents, this study was done to determine the protective effect of alcohol on muscle paralysis induced by atracurium in preparation of isolated chicken biventer cervices muscle.
Materials and Methods: This experimental study was performed on two groups of chicken biventer cervices muscles. In each group, 6 chickens were recruited. After inserting the muscles in an organ bath containing Tirod physiologic solution and oxygen at 37°c, atracurium was introduced to the first group. A combination of alcohol and atracurium was added to the second group. The percentage of muscle paralysis and duration of contraction in each group were then registered. A student t-test was performed for analysis of the data.
Results: Percent of muscle paralysis followed by atracurium introduction in chick biventer cervices muscle was decreased in the presence of ethanol (p<0.01). Duration of paralysis was decreased also in the group receiving ethanol compared with the group receiving atracurium alone (p<0.01).
Conclusion: Results suggested that ethanol with possible presynaptic and postsynaptic effects can protect the muscle against the paralysis induced by atracurium.
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مقاله پژوهشی |
دریافت: 1387/7/7 | پذیرش: 1396/3/28 | انتشار: 1396/3/28