شنبه 17 خرداد 1404
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دوره 25، شماره 109 - ( 2-1396 )
جلد 25 شماره 109 صفحات 10-1 |
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Heidari Oranjaghi N, Azhdari Zarmehri H, Ghasemi Dashkasan E, GanJKhani M. Assessment of the Involvement of Orexin Receptor 1 in Acute Food Deprivation on Nociceptive Behavior Induced by Hot Plate Test in Male Rats. J Adv Med Biomed Res 2017; 25 (109) :1-10
URL: http://journal.zums.ac.ir/article-1-4095-fa.html
URL: http://journal.zums.ac.ir/article-1-4095-fa.html
حیدری اورنجقی نیما، اژدری زرمهری حسن، قاسمی داشکسن المیرا، گنج خانی مهین. بررسی دخالت گیرنده‌ی 1 اورکسین در محرومیت غذایی حاد روی رفتارهای دردی ناشی از آزمون صفحه‌ی داغ در موش بزرگ آزمایشگاهی نر. Journal of Advances in Medical and Biomedical Research. 1396; 25 (109) :1-10
1- دانشگاه علوم پزشکی زنجان
2- دانشگاه علوم پزشکی تربت حیدریه
3- دانشگاه تربیت مدرس تهران
2- دانشگاه علوم پزشکی تربت حیدریه
3- دانشگاه تربیت مدرس تهران
چکیده: (153879 مشاهده)
Background and Objective: Food deprivation increases the expression of orexin-1 receptor gene in the hypothalamus. On the other hand, food deprivation induces analgesia and orexin has a fundamental and well known role in pain modulation. This study aimed to determine the role of orexin receptor 1 antagonist in analgesic effect of acute food deprivation (12 h) by hot plate test in male rats.
Materials and Methods: Male Wistar rats were divided into 5 groups (n=8), control, food deprivation without surgery, stereotaxic surgery with vehicle, vehicle and food deprivation and food deprivation and orexin receptor 1 antagonist groups. 12 hours before the hot plate test, food was removed from the animals’ proximity, but water was freely available. All groups were tested using the hot plate. Data were analyzed statistically by one-way ANOVA with Tukey post hoc test.
Results: According to our findings, orexin receptor 1 antagonist injection increased pain related behaviors at the time of 5(P<0.05), 15(P<0.05), 30(P<0.01) and 60(P<0.001) minutes in the hot plate test.
Conclusion: Orexin plays an important role in feeding state–induced pain modulation. Based on our results, change in pain behavior induced by food deprivation may be related to change in orexin expression or in orexin receptors density.
نوع مطالعه: کارآزمایی بالینی |
دریافت: 1395/9/22 | پذیرش: 1395/9/22 | انتشار: 1395/9/22
دریافت: 1395/9/22 | پذیرش: 1395/9/22 | انتشار: 1395/9/22
فهرست منابع
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