دوره 25، شماره 109 - ( 2-1396 )                   جلد 25 شماره 109 صفحات 49-36 | برگشت به فهرست نسخه ها

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Yaribeygi H, Mohammadi M T. Protective Effect of Crocin on Kidney Performance in Chronic Uncontrolled Hyperglycemia-Induced Nephropathy in Rat. J Adv Med Biomed Res 2017; 25 (109) :36-49
URL: http://journal.zums.ac.ir/article-1-4098-fa.html
یاری بیگی حبیب، محمدی محمد تقی. تاثیر محافظتی کروسین بر عملکرد کلیه در نفروپاتی ناشی از هیپرگلیسمی مزمن کنترل نشده در موش صحرایی. Journal of Advances in Medical and Biomedical Research. 1396; 25 (109) :36-49

URL: http://journal.zums.ac.ir/article-1-4098-fa.html


1- دانشگاه علوم پزشکی بقیه الله تهران
2- دانشگاه علوم پزشکی بقیه الله تهران ، Mohammadi.mohammadt@yahoo.com
چکیده:   (154311 مشاهده)

Background and Objective: Based on previous studies, inflammation and oxidative stress play a crucial role in the pathophysiology of diabetic nephropathy. Therefore, we aimed to examine the protective effects of crocin, as a potent anti-inflammatory and antioxidant, on kidney function and oxidative stress in an experimental model of diabetic nephropathy in male wistar rats.

Materials and Methods: In this experimental study, male wistar rats (190-220 g) were randomly divided into four groups (each n=6); normal, normal treatment, diabetic, diabetic treatment. The rats were made diabetic by an intravenous injection of streptozotocin (40 mg/kg). Treated rats received crocin intraperitoneally with a dose of 40 mg/kg/day for eight weeks. Blood samples were collected for measurement of blood glucose and creatinine levels. The Malondialdehyde (MDA) and nitrate contents of kidney also were assessed.

Results: Chronic hyperglycemia (blood glucose >400 mg/dL) significantly increased the blood creatinine of the diabetic group (4.51±0.45 mg/dL) compared with normal rats (0.72±0.09 mg/dL, P<0.001). Hyperglycemia also decreased the nitrate content (37%) accompanied by an increase in the MDA content (13.00±0.19 µg/mg protein) compared with normal group (10.22±0.54 µg/mg protein). Crocin significantly decreased the blood creatinine of diabetic rats (1.12±0.13 mg/dL, P<0.001), accompanied by a decrease in blood glucose (9%). Finally, the content of MDA significantly decreased by 29% in diabetic treated rats compare to diabetic untreated rats (P<0.001).

Conclusion: Based on the findings of the present study, it is appeared that crocin has a role in the prevention of diabetic nephropathy through inhibition of oxidative stress and reducing lipid oxidation.

متن کامل [PDF 853 kb]   (156465 دریافت)    
نوع مطالعه: کارآزمایی بالینی |
دریافت: 1395/9/22 | پذیرش: 1395/9/22 | انتشار: 1395/9/22

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