دوره 25، شماره 112 - ( 5-1396 )                   جلد 25 شماره 112 صفحات 107-99 | برگشت به فهرست نسخه ها

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Ferdousi F, Taromchi A H, Esmaeilzadeh A. Survey of Interleukin 10 Gene Promoter Polymorphisms at Position -592 (A/C) and -1082 (A/G) in Type 2 Diabetes Patients in Northwest Iran. J Adv Med Biomed Res 2017; 25 (112) :99-107
URL: http://journal.zums.ac.ir/article-1-4595-fa.html
فردوسی فرزین، تارمچی امیر حسین، اسماعیل‌زاده عبدالرضا. بررسی پلی‌مورفیسم‌های A/C592- و A /G1082- ناحیه پروموتر ژن اینترلوکین 10 در افراد مبتلا به دیابت نوع دو در شمال غرب ایران. Journal of Advances in Medical and Biomedical Research. 1396; 25 (112) :99-107

URL: http://journal.zums.ac.ir/article-1-4595-fa.html


1- دانشگاه آزاد اسلامی، زنجان
2- دانشکده‌ی پزشکی، دانشگاه علوم پزشکی زنجان، زنجان
3- مرکز تحقیقات بیمارهای متابولیک، دانشگاه علوم پزشکی زنجان، زنجان
چکیده:   (150772 مشاهده)

Background and Objective: Today diabetes is one of the most prevalent noncontagious diseases around the world. There is strong evidence showing inflammatory reactions play a crucial role in initiating this disease. Interleukin 10 is one of the most significant anti-inflammatory cytokines. Thus the present study was conducted to investigate the relationship between Interleukin 10 gene polymorphisms -592 A/C and -1082 A/G and susceptibility to type 2 diabetes patients (T2D).

Materials and Methods: In this study 75 T2D patients and 75 healthy controls were selected. DNA extraction was carried out and then the genotype in the -592 A/C and -1082A/G positions were determined using PCR-RFLP while chi squared (X2) was used as the statistical method for data analysis.

Results: The frequency of genotype AC and CC in the -592A/C position was significantly higher in type 2 diabetes patients compared to healthy controls (p<0.05).

Conclusions: The high frequency of C allele in -592A/C can be considered as a predisposing factor for type 2 diabetes.

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نوع مطالعه: کارآزمایی بالینی |
دریافت: 1396/3/24 | پذیرش: 1396/3/24 | انتشار: 1396/3/24

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