دوره 26، شماره 115 - ( 3-1397 )                   جلد 26 شماره 115 صفحات 77-69 | برگشت به فهرست نسخه ها

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Shakibaei D, Gorgani R, Hesari M, Bahrami G, Kiani A. Protective Effects of Garlic Powder on the Performance of Testosterone- Induced Cardiac Hypertrophy in Rats. J Adv Med Biomed Res 2018; 26 (115) :69-77
URL: http://journal.zums.ac.ir/article-1-5051-fa.html
شکیبایی داریوش، گرگانی رامین، حصاری مهوش، بهرامی غلامرضا، کیانی امیر. بررسی اثرات محافظتی پودر سیر بر عملکرد قلب هایپرتروفی شده ناشی از تستوسترون در موش صحرایی. Journal of Advances in Medical and Biomedical Research. 1397; 26 (115) :69-77

URL: http://journal.zums.ac.ir/article-1-5051-fa.html

بررسی اثرات محافظتی پودر سیر بر عملکرد قلب هایپرتروفی شده ناشی از تستوسترون در موش صحرایی
داریوش شکیبایی1 ، رامین گرگانی1 ، مهوش حصاری*2 ، غلامرضا بهرامی1 ، امیر کیانی1
1- دانشگاه علوم پزشکی کرمانشاه، کرمانشاه
2- دانشگاه علوم پزشکی کرمانشاه، کرمانشاه ، mahvashhesari@gmail.com
چکیده:   (154026 مشاهده)

Background and Objective: The androgens cause the cardiac hypertrophy and cardiomyopathy. There are reports of garlic protective effects in the cardiac hypertrophy due to overload and catecholamine. The aim of this study was to investigate the effects of garlic powder on testosterone-induced cardiac hypertrophy in rats.
Materials and Methods: This experimental study was performed on Wistar male rats in 5 groups (n = 8-7) including the testosterone group (10 mg testosterone enanthate for 20 days), the garlic group (1.6 g for 10 days) Day), the control garlic group and finally the garlic + testosterone. The separated hearts were perfused according to Langendorff method and passed three basal stages, ischemia and reperfusion. The structural and functional parameters of left ventricular fluctuations (LVDP), ventricular contractility (dp / dt) and (RPP) were measured.
Results: In the testosterone-induced hypertrophy group, the cardiac weight, the thickness of the left ventricular wall and the functional parameters of the heart, such as LVDP, RPP, + dp / dt, and -dp / dt indicated significant increase. The use of garlic powder in the base period led to a significant decrease in these parameters (P <0.05). However, in the period of ischemic reperfusion, the effect was not significant.
Conclusion: The results showed that the garlic powder modifies the cardiac hypertrophy induced by testosterone administration in rats. In other words, the use of garlic powder could potentially reduce the severity of cardiac hypertrophy in rats, due to variations in functional and structural parameters.

متن کامل [PDF 2139 kb]   (157525 دریافت)    
نوع مطالعه: کارآزمایی بالینی |
دریافت: 1396/11/16 | پذیرش: 1396/11/16 | انتشار: 1396/11/16
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