دوره 27، شماره 120 - ( 10-1397 )                   جلد 27 شماره 120 صفحات 36-30 | برگشت به فهرست نسخه ها


XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hedayat yaghobi M, Razipour S, Sabahi M. A 10-years study of vertebral osteomyelitis in Hamadan, West of Iran. J Adv Med Biomed Res 2019; 27 (120) :30-36
URL: http://journal.zums.ac.ir/article-1-5288-fa.html
هدایت یعقوبی مجتبی، رضی پور شهاب، صباحی محمدمهدی. مطالعۀ 10 سالۀ استئوئیلیت مهره‌ای در همدان ، غرب ایران. Journal of Advances in Medical and Biomedical Research. 1397; 27 (120) :30-36

URL: http://journal.zums.ac.ir/article-1-5288-fa.html


1- متخصص عفونی، استادیار دانشگاه علوم پزشکی همدان
2- کمیته ی تحقیقات دانشجویی،دانشگاه علوم پزشکی همدان
3- کمیته ی تحقیقات دانشجویی،دانشگاه علوم پزشکی همدان ، mmsabahi1996@gmail.com
چکیده:   (148418 مشاهده)

Background and Objective: Epidemiology and predisposing factors of spondylodiscitis or vertebral osteomyelitis are different in different populations. This study was conducted to delineate the epidemiology and microbiological status of in Hamedan, Iran.
Materials and Methods: In this retrospective study, all patients with definite diagnosis of spondylodiscitis (changing of intervertebral disc and adjacent vertebral MRI signal) hospitalized in Besat and Farshchian Hospitals of Hamedan between 2006 and 2015 (during 10 years) were enrolled by convenience sampling. Data on age, gender, underlying disease, constitutional symptoms, place of acquiring infection, leukocytosis, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), surgical intervention, vertebral biopsy culture, anemia, abscess, place of vertebral involvement, positive brucellosis test, and blood culture results were obtained from the patients’ medical files and recorded in a questionnaire.
Results: A total of 71 patients with spondylodiscitis (mean age: 49.56 years) were enrolled. Brucella (n: 27, 38%) was the leading cause of the disease followed by tuberculosis (n: 11, 15.5%). Although 34 patients had positive serologic test for Brucella, other agents were causes of the disease according to course of treatment and vertebral biopsy in 7 of them. In 21 cases, the cause of the disease was unknown. The most common place of involvement was lumbosacral region (78.9%).
Conclusion: Unlike Infectious Diseases Society of America (IDSA) guideline that do not recommend to perform age-guided aspiration biopsy in suspected cases of spondylodiscitis when Brucella is endemic and whereby people have strong positive serology, our results demonstrated that, even in case of positive Brucella test, other factors are likely to contribute to acquiring spondylodiscitis, and vertebral biopsy is recommended for definite diagnosis. Early diagnosis is necessary to select appropriate antibiotic and treat spondylodiscitis early.

متن کامل [PDF 290 kb]   (157018 دریافت)    
نوع مطالعه: مقاله پژوهشی | موضوع مقاله: Epidemiologic Studies
دریافت: 1397/5/8 | پذیرش: 1397/10/2 | انتشار: 1398/6/25

فهرست منابع
1. Butler JS, Shelly MJ, Timlin M, Powderly WG, O'Byrne JM. Nontuberculous pyogenic spinal infection in adults: a 12-year experience from a tertiary referral center. Spine (Phila Pa 1976). 2006; 31(23): 2695-700. [DOI:10.1097/01.brs.0000244662.78725.37] [PMID]
2. Viezens L, Schaefer C, Helmers R, Vettorazzi E, Schroeder M, Hansen-Algenstaedt N. Spontaneous pyogenic spondylodiscitis in the thoracic or lumbar spine: a retrospective cohort study comparing the safety and efficacy of minimally invasive and open surgery over a nine-year period. World Neurosurg. 2017; 102: 18-27. [DOI:10.1016/j.wneu.2017.02.129] [PMID]
3. Cottle L, Riordan T. Infectious spondylodiscitis. J Infect. 2008; 56(6): 401-12. [DOI:10.1016/j.jinf.2008.02.005] [PMID]
4. Grammatico L, Baron S, Rusch E, et al. Epidemiology of vertebral osteomyelitis (VO) in France: analysis of hospital-discharge data 2002-2003. Epidemiol Infect. 2008; 136(5): 653-60. [DOI:10.1017/S0950268807008850] [PMID] [PMCID]
5. Premru MM, Spik VC, Furlan SL, Zupanc TL. Clinical appearance of Staphylococcus aureus spondylodiscitis and molecular characterization of the isolates. Scand J Infect Dis. 2010; 42(10): 763-6. [DOI:10.3109/00365548.2010.492398] [PMID]
6. D'Agostino C, Scorzolini L, Massetti AP, et al. A seven-year prospective study on spondylodiscitis: epidemiological and microbiological features. Infection. 2010; 38(2): 102-7. [DOI:10.1007/s15010-009-9340-8] [PMID]
7. Skaf GS, Kanafani ZA, Araj GF, Kanj SS. Non-pyogenic infections of the spine. Int J Antimicrob Agents. 2010; 36(2): 99-105. [DOI:10.1016/j.ijantimicag.2010.03.023] [PMID]
8. Menon KV, Sorour TM. Epidemiologic and demographic attributes of primary spondylodiscitis in a middle eastern population sample. World Neurosurg. 2016; 95: 31-9. [DOI:10.1016/j.wneu.2016.07.088] [PMID]
9. Govender S. Spinal infections. J Bone Joint Surg Br. 2005; 87(11): 1454-8. [DOI:10.1302/0301-620X.87B11.16294] [PMID]
10. McHenry MC, Easley KA, Locker GA. Vertebral osteomyelitis: long-term outcome for 253 patients from 7 Cleveland-area hospitals. Clin Infect Dis. 2002; 34(10): 1342-50. [DOI:10.1086/340102] [PMID]
11. Guerado E, CervanAM. Surgical treatment of spondylodiscitis. An update. Int Orthop. 2012; 36(2): 413-20. [DOI:10.1007/s00264-011-1441-1] [PMID] [PMCID]
12. Kaptan F, Gulduren HM, Sarsilmaz A, et al. Brucellarspondylodiscitis: comparison of patients with and without abscesses. Rheumatol Int. 2013; 33(4): 985-92. [DOI:10.1007/s00296-012-2491-4] [PMID]
13. Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global map of human Brucellosis. Lancet Infect Dis. 2006; 6(2): 91-9. [DOI:10.1016/S1473-3099(06)70382-6]
14. Soares do, Brito J, Tirado A, Fernandes P. Surgical treated spondylodiscitis epidemiological study. Acta Med Port. 2016; 29(5): 319-25. [DOI:10.20344/amp.6549] [PMID]
15. Cebrian Parra JL, Saez-Arenillas Martin A, Urda Martinez-Aedo AL, SolerIvanez I, Agreda E, Lopez-Duran Stern L. Management of infectious discitis. Outcome in one hundred and eight patients in a university hospital. Int Orthop. 2012; 36(2): 239-44. [DOI:10.1007/s00264-011-1445-x] [PMID] [PMCID]
16. Glaudemans AW, Quintero AM, Signore A. PET/MRI in infectious and inflammatory diseases: will it be a useful improvement? Eur J Nucl Med Mol Imaging. 2012; 39(5): 745-9. [DOI:10.1007/s00259-012-2060-9] [PMID] [PMCID]
17. Aagaard T, Roed C, Dahl B, Obel N. Long-term prognosis and causes of death after spondylodiscitis: A Danish nationwide cohort study. Infect Dis (Lond). 2016; 48(3): 201-8. [DOI:10.3109/23744235.2015.1103897] [PMID]
18. Horasan ES, Colak M, Ersoz G, Uguz M, Kaya A. Clinical findings of vertebral osteomyelitis: Brucella spp. versus other etiologic agents. Rheumatol Int. 2012; 32(11): 3449-53. [DOI:10.1007/s00296-011-2213-3] [PMID]
19. Berbari EF, Kanj SS, Kowalski TJ, et al. Infectious Diseases Society of America (IDSA) clinical practice guidelines for the diagnosis and treatment of native vertebral osteomyelitis in adults. Clin Infect Dis. 2015; 15; 61(6): e26-46. [DOI:10.1093/cid/civ482] [PMID]
20. Hopkinson N, Stevenson J, Benjamin S. A case ascertainment study of septic discitis: clinical, microbiological and radiological features. QJM. 2001; 94(9): 465-70. [DOI:10.1093/qjmed/94.9.465] [PMID]
21. Doganay M, Aygen B. Human Brucellosis: an overview. Int J Infect Dis. 2003; 1; 7(3): 173-82. [DOI:10.1016/S1201-9712(03)90049-X]
22. Hasanjani Roushan MR, Mohrez M, SmailnejadGangi SM, SoleimaniAmiri MJ, Hajiahmadi M. Epidemiological features and clinical manifestations in 469 adult patients with Brucellosis in Babol, Northern Iran. Epidemiol Infect. 2004; 132(6): 1109-14. [DOI:10.1017/S0950268804002833] [PMID] [PMCID]
23. Bhavan KP, Marschall J, Olsen MA, Fraser VJ, Wright NM, Warren DK. The epidemiology of hematogenous vertebral osteomyelitis: a cohort study in a tertiary care hospital. BMC Infect Dis. 2010; 10: 158. doi: 10.1186/1471-2334-10-158. [DOI:10.1186/1471-2334-10-158] [PMID] [PMCID]
24. Sheikh AF, Khosravi AD, Goodarzi H, et al. pathogen identification in suspected cases of pyogenic spondylodiscitis. Front Cell Infect Microbiol. 2017; 7: 60. [DOI:10.3389/fcimb.2017.00060] [PMID] [PMCID]
25. Solis Garcia delPozo J, Vives Soto M, Solera J. Vertebral osteomyelitis: long-term disability assessment and prognostic factors. J Infect. 2007; 54(2): 129-34. [DOI:10.1016/j.jinf.2006.01.013] [PMID]
26. Mylona E, Samarkos M, Kakalou E, Fanourgiakis P, Skoutelis A. Pyogenic vertebral osteomyelitis: a systematic review of clinical characteristics. Semin Arthritis Rheum. 2009; 39(1): 10-7. [DOI:10.1016/j.semarthrit.2008.03.002] [PMID]
27. Kaya S, Ercan S, Kaya S, et al. Spondylodiscitis: evaluation of patients in a tertiary hospital. J Infect Dev Ctries. 2014; 8(10): 1272-6. [DOI:10.3855/jidc.4522] [PMID]
28. Hu T, Wu J, Zheng C, Wu D. Brucellarspondylodiscitis with rapidly progressive spinal epidural abscess showing caudaequina syndrome. Spinal Cord Ser Cases. 2016; 2: 15030. [DOI:10.1038/scsandc.2015.30] [PMID] [PMCID]
29. Ulu-Kilic A, Karakas A, Erdem H, et al. Update on treatment options for spinal Brucellosis. Clin Microbiol Infect. 2014; 20(2): O75-82. [DOI:10.1111/1469-0691.12351] [PMID]
30. Shioya N, Ishibe Y, Kan S, et al. Sternoclavicular joint septic arthritis following paraspinal muscle abscess and septic lumbar spondylodiscitis with epidural abscess in a patient with diabetes: a case report. BMC Emerg Med. 2012; 12: 7. [DOI:10.1186/1471-227X-12-7] [PMID] [PMCID]
31. Jensen AG, Espersen F, Skinhoj P, Frimodt-Moller N. Bacteremic Staphylococcus aureus spondylitis. Arch Intern Med. 1998; 158(5): 509-17. [DOI:10.1001/archinte.158.5.509] [PMID]
32. Khan MH, Smith PN, Rao N, Donaldson WF. Serum C-reactive protein levels correlate with clinical response in patients treated with antibiotics for wound infections after spinal surgery. Spine J. 2006; (3): 311-5. [DOI:10.1016/j.spinee.2005.07.006] [PMID]
33. Jabalameli M, Ameri E. Bone and joint tuberculosis, Review of the patients treated in the ShafaYahiaian Hospital, 1350-74. Tehran Univ Med J. 1998; 56(4): 62-6.
34. Abdi-Liae Z, Soudbakhsh A, Jafari S, Tomaj HE. Haematological manifestations of Brucellosis. Acta MedicaIranica. 2007; 45(2): 145-8.
35. Celik AD, Yulugkural Z, Kilincer C, Hamamcioglu MK, Kuloglu F, Akata F. Negative serology: could exclude the diagnosis of Brucellosis? Rheumatol Int. 2012; 32(8): 2547-9. [DOI:10.1007/s00296-010-1453-y] [PMID]

ارسال پیام به نویسنده مسئول


بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به Journal of Advances in Medical and Biomedical Research می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2025 CC BY-NC 4.0 | Journal of Advances in Medical and Biomedical Research

Designed & Developed by : Yektaweb