دوره 27، شماره 124 - ( 6-1398 )                   جلد 27 شماره 124 صفحات 51-47 | برگشت به فهرست نسخه ها


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Besharati S, Tavakkolian P, Borji R. Autoimmune Polyglandular Syndrome Type 2 (APS-2) in a 70-Year-Old Woman: A Case Report. J Adv Med Biomed Res 2019; 27 (124) :47-51
URL: http://journal.zums.ac.ir/article-1-5575-fa.html
Autoimmune Polyglandular Syndrome Type 2 (APS-2) in a 70-Year-Old Woman: A Case Report. Journal of Advances in Medical and Biomedical Research. 1398; 27 (124) :47-51

URL: http://journal.zums.ac.ir/article-1-5575-fa.html


چکیده:   (144498 مشاهده)

Type 2 autoimmune polyglandular (Schmidt) syndrome (APS-2) is defined by the occurrence of at least 2 out of 3 of the following manifestations, Addison's disease, Hypothyroidism and Type 1 diabetes mellitus. APS-2 is a rare condition with an incidence of 1–2/100 000 per year. Prevalence of APS-2 is most happening in the range of 20-40 years of age. Here we present a patient who complained about loss of appetite with significant weight loss also having trouble with her skin saying she had experienced progressively darkening of the skin all over her body and manifestations of Addison's disease at the age of 70. The patient was treated with oral Prednisolone, Fludrocortisone and Levothyroxine and evaluated after one month which showed the hormonal panel within the normal range.

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نوع مطالعه: گزارش موردی | موضوع مقاله: Clinical Medicine
دریافت: 1397/12/13 | پذیرش: 1398/12/17 | انتشار: 1398/12/17

فهرست منابع
1. Husebye ES, Anderson MS, Kämpe O. Autoimmune polyendocrine syndromes. N Engl J Med. 2018; 378(12): 1132-41. [DOI:10.1056/NEJMra1713301]
2. Sperling M, Yau M. Autoimmune polyglandular syndromes. In: De Groot LJ, Chrousos G, Dungan K, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279152
3. Dittmar M, Kahaly GJ. Polyglandular autoimmune syndromes: immunogenetics and long-term follow-up. J Clin Endocrinol Metab. 2003; 88(7): 2983-92 [DOI:10.1210/jc.2002-021845]
4. Singh G, Jialal I. Polyglandular autoimmune syndrome, Type II (Carpenters, Schmidt). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK525992/
5. Förster G, Krummenauer F, Kühn I, Beyer J, Kahaly G. Polyglandular autoimmune syndrome type II: epidemiology and forms of manifestation. Dtsch. Med. Wochenschr. 1999; 124(49):1476-81. [DOI:10.1055/s-2008-1035684]
6. Cooper GS, Stroehla BC. The epidemiology of autoimmune diseases. Autoimmun Rev. 2003. 2(3): 119-25 [DOI:10.1016/S1568-9972(03)00006-5]
7. Michels A, Gottlieb P. Autoimmune polyglandular syndromes. Nat Rev Endocrinol. 2010; 6(5): 270-7 [DOI:10.1038/nrendo.2010.40]
8. Cutolo M. Autoimmune polyendocrine syndromes. Autoimmun Rev. 2014; 13(2): 85-9 [DOI:10.1016/j.autrev.2013.07.006]
9. Simmonds MJ, Gough SC. Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clin Exp Immunol. 2004; 136(1): 1-10. [DOI:10.1111/j.1365-2249.2004.02424.x]
10. Erichsen MM, Lovas K, Skinningsrud B, et al. Clinical, immunological, and genetic features of autoimmune primary adrenal insufficiency: observations from a norwegian registry. J Clin Endocrinol Metab. 2009; 94(12): 4882-90 [DOI:10.1210/jc.2009-1368]

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