جمعه 26 اردیبهشت 1404
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دوره 27، شماره 125 - ( 9-1398 )
جلد 27 شماره 125 صفحات 33-25 |
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Roshankhah S, Abdolmaleki A, Jalili C, Salahshoor M R. Crocin Reduces Oxidative Stress Produced by Busulfan Administration on Fertility of Male Rats. J Adv Med Biomed Res 2019; 27 (125) :25-33
URL: http://journal.zums.ac.ir/article-1-5775-fa.html
URL: http://journal.zums.ac.ir/article-1-5775-fa.html
Crocin Reduces Oxidative Stress Produced by Busulfan Administration on Fertility of Male Rats. Journal of Advances in Medical and Biomedical Research. 1398; 27 (125) :25-33
چکیده: (143614 مشاهده)
Background & Objective: Busulfan (BUS) as a drug for cancer treatment can produce free radicals. Crocin (CRO) is a potent antioxidant with beneficial effects. This study was designed to evaluate the effects of CRO against BUS-related damages to the male rats reproductive parameters.
Materials & Methods: Forty-eight male rats were randomly assigned into 8 groups; Group 1 (normal control group) received normal saline; Group 2 (BUS control group) received 10 mg/kg/body weight (b.w.) of BUS; Group 3-5 (CRO groups) received 12.5, 25.0, 50.0 mg/kg/b.w. of CRO, respectively; Group 6-8 (BUS + CRO groups) received BUS + CRO. Treatments were administered daily by intraperitoneal injection in a five-week period. The sperm parameters, testis malondialdehyde (MDA), total antioxidant capacity (TAC), testosterone level, and germinal layer height were evaluated histologically and analyzed statistically.
Results: All parameters reduced significantly in the BUS control group compared to the normal control group (P<0.01) except the MDA level (which increased). The CRO and CRO + BUS treatments in all doses increased whole parameters significantly compared to the BUS control group (P<0.01) except MDA level (which decreased). No significant modifications were observed in all CRO groups compared to the normal control group (P>0.05).
Conclusion: It seems that CRO could increase the quality of spermatozoa and improves BUS -induced adverse effects on male fertility parameters.
نوع مطالعه: مقاله پژوهشی |
موضوع مقاله:
Medical Biology
دریافت: 1398/5/11 | پذیرش: 1398/6/10 | انتشار: 1398/6/29
دریافت: 1398/5/11 | پذیرش: 1398/6/10 | انتشار: 1398/6/29
فهرست منابع
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