In this study, thrombolytic therapy is described and a case of left subclavian artery thrombosis with acute clinical symptoms is presented. The patient was an 82-year-old woman with the symptoms of axillary artery thrombosis. Catheter-directed thrombolysis was performed and thrombolytic medication was injected via a catheter. In addition, a low dose of heparin was infused intravenously. Following treatment, clinical symptoms were normal. The repeated angiography indicated a good blood flow to the left upper distal limb. Minimally invasive methods, such as catheter-based thrombolytic therapy may be a suitable alternative for patients with viable limb acute ischemia.