پنجشنبه 1 آذر 1403
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دوره 30، شماره 139 - ( 11-1400 )
جلد 30 شماره 139 صفحات 153-146 |
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Noroozi F, Asle-Rousta M, Rahnema M. Flaxseed Oil and Treadmill Running Improve Behavioral Outcomes in Rats Exposed to Lead. J Adv Med Biomed Res 2022; 30 (139) :146-153
URL: http://journal.zums.ac.ir/article-1-6320-fa.html
URL: http://journal.zums.ac.ir/article-1-6320-fa.html
Flaxseed Oil and Treadmill Running Improve Behavioral Outcomes in Rats Exposed to Lead. Journal of Advances in Medical and Biomedical Research. 1400; 30 (139) :146-153
چکیده: (93887 مشاهده)
Background and Objective: Lead entry into the body causes considerable damages to the brain in the long term. We aimed to investigate the effects of exercise (treadmill running) and flaxseed oil on lead acetate-induced behavioral deficits in male rats.
Materials and Methods: 60 rats were divided into 6 groups: Control (C), Exercise (Ex), Flaxseed oil (FO), Lead (L), Lead- Exercise (L-Ex), and Lead- Flaxseed oil (L-FO). Groups L, L-Ex, and L-FO obtained 100 mg/kg of lead acetate, and groups FO and L-FO received 4 ml/kg (by gavage) of flaxseed oil for 28 consecutive days and Ex, and L-Ex groups ran on the treadmill. At the end of the session, spatial memory, depression, and anxiety behaviors were examined utilizing Morris water maze, forced swimming test, and elevated plus maze respectively.
Results: Lead acetate impaired learning and memory and led to depression and anxiety in rats. Treadmill running and flaxseed oil, both, improved learning and memory and decreased anxiety, but unlike treadmill running, flaxseed oil could not prevent depression resulted from lead consumption.
Conclusion: Exercising (treadmill running) and flaxseed oil prevent lead-induced behavioral deficits.
نوع مطالعه: مقاله پژوهشی |
موضوع مقاله:
Life science
دریافت: 1399/9/17 | پذیرش: 1400/1/3 | انتشار: 1400/11/11
دریافت: 1399/9/17 | پذیرش: 1400/1/3 | انتشار: 1400/11/11
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