یکشنبه 18 خرداد 1404
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دوره 10، شماره 39 - ( 4-1381 )
جلد 10 شماره 39 صفحات 4-1 |
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Taheri S, Sohrabi D. Teratogenic Effects Of Sodium Benzoate On The Rat Fetus. J Adv Med Biomed Res 2002; 10 (39) :1-4
URL: http://journal.zums.ac.ir/article-1-652-fa.html
URL: http://journal.zums.ac.ir/article-1-652-fa.html
طاهری شهلا، سهرابی داود. بررسی اثرات تراتوژنیک بنزوات سدیم بر روی جنین موش صحرایی. Journal of Advances in Medical and Biomedical Research. 1381; 10 (39) :1-4
چکیده: (153099 مشاهده)
Background: Sodium Benzoate is one of the chemical products that is used as a preservative in foods, canned foods, juices, and beverages. In this research, teratogenic effects of Sodium Benzoate with two different doses on rat fetus were studied.
Materials and Methods: This experimental research was conducted on 15 rats with 250-350 grams weight which were divided into three groups. Two does of 9.3 and 18.6 mmol/kg of Sodium Benzoate diluted in normal saline were injected intrapritoneally to groups one and two of experimentally pregnant rats in days 7, 8, and 9 of injection respectively. Normal saline was injected only to the control group. In day 20, the height and weight of all the fetuses, and also the weight and diameter of their placentas were measured. Then, their appearance was studied using stereomicroscope. Tissue sections were prepared and stained using hematoxiline eosin. Finally, fetus parameters were statistically analyzed in three groups by variance analyzing test.
Results: The results showed that the height and weight of fetuses in the sample groups had reduced significantly in comparison with that of control group (P<0.05), and there was a significantly higher prevalence of death among fetuses in the sample groups in comparison with control group. However, no histological changes were observed in the tissues.
Conclusion: Sodium Benzoate can reduce the weight and height of rat fetuses. Other researches on its amount in canned foods are recommended. Also pregnant women are advised not to consume foods containing Sodium Benzoate up to the second month of pregnancy.
Materials and Methods: This experimental research was conducted on 15 rats with 250-350 grams weight which were divided into three groups. Two does of 9.3 and 18.6 mmol/kg of Sodium Benzoate diluted in normal saline were injected intrapritoneally to groups one and two of experimentally pregnant rats in days 7, 8, and 9 of injection respectively. Normal saline was injected only to the control group. In day 20, the height and weight of all the fetuses, and also the weight and diameter of their placentas were measured. Then, their appearance was studied using stereomicroscope. Tissue sections were prepared and stained using hematoxiline eosin. Finally, fetus parameters were statistically analyzed in three groups by variance analyzing test.
Results: The results showed that the height and weight of fetuses in the sample groups had reduced significantly in comparison with that of control group (P<0.05), and there was a significantly higher prevalence of death among fetuses in the sample groups in comparison with control group. However, no histological changes were observed in the tissues.
Conclusion: Sodium Benzoate can reduce the weight and height of rat fetuses. Other researches on its amount in canned foods are recommended. Also pregnant women are advised not to consume foods containing Sodium Benzoate up to the second month of pregnancy.
نوع مطالعه: مقاله پژوهشی |
دریافت: 1387/9/9 | پذیرش: 1381/3/25 | انتشار: 1381/3/25
دریافت: 1387/9/9 | پذیرش: 1381/3/25 | انتشار: 1381/3/25
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