یکشنبه 18 خرداد 1404
[Archive]
دوره 32، شماره 154 - ( 7-1403 )
جلد 32 شماره 154 صفحات 392-386 |
برگشت به فهرست نسخه ها
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Hassanpour S, Hajimoradi S, Malekpour F. Antiepileptic Role of β-alanine on Pentylenetetrazol-Induced Convulsions during Estrus Cycle in Rat. J Adv Med Biomed Res 2024; 32 (154) :386-392
URL: http://journal.zums.ac.ir/article-1-7382-fa.html
URL: http://journal.zums.ac.ir/article-1-7382-fa.html
Antiepileptic Role of β-alanine on Pentylenetetrazol-Induced Convulsions during Estrus Cycle in Rat. Journal of Advances in Medical and Biomedical Research. 1403; 32 (154) :386-392
چکیده: (319 مشاهده)
Background & Objective: Epilepsy is one of the main neurological disorders and β-alanine has several beneficial in the nervous system.This study aimed to determine the antiepileptic effect of the β-alanine during estrous cycle in pentylenetetrazol (PTZ)-induced seizures in rat.
Materials & Methods: Thirty female rats were allocated into five experimental groups as control, sodium valproate (75 mg/kg), and β-alanine (15, 30 and 45 mg/kg) during estrus cycle (proestrus, estrus, metestrus and diestrus). Puberty was determined by vaginal smears whereby animals with two normal cycles were chosen. After administration of the sodium valproate or β-alanine, PTZ injection (80 mg/kg, i.p) was done. Animals were monitored for 30 minutes with initiation time of myoclonic seizures (ITMS), initiation time of tonic–clonic seizures (ITTS), and seizures’ duration (SD) registered.
Results: Based on the findings, β-alanine (30 and 45 mg/kg) significantly increased the onset time of ITMS and ITTS compared to the control group (P<0.05). β-alanine (30 and 45 mg/kg) significantly reduced SD compared to the control group (P<0.05). The antiepileptic effect of β-alanine was more prominent during metestrus and diestrus than proestrus and estrus (P<0.05).
Conclusion: It seems β-alanine has antiepileptic effects which are more prominent during proestrus and estrus than metestrus and diestrus.
Materials & Methods: Thirty female rats were allocated into five experimental groups as control, sodium valproate (75 mg/kg), and β-alanine (15, 30 and 45 mg/kg) during estrus cycle (proestrus, estrus, metestrus and diestrus). Puberty was determined by vaginal smears whereby animals with two normal cycles were chosen. After administration of the sodium valproate or β-alanine, PTZ injection (80 mg/kg, i.p) was done. Animals were monitored for 30 minutes with initiation time of myoclonic seizures (ITMS), initiation time of tonic–clonic seizures (ITTS), and seizures’ duration (SD) registered.
Results: Based on the findings, β-alanine (30 and 45 mg/kg) significantly increased the onset time of ITMS and ITTS compared to the control group (P<0.05). β-alanine (30 and 45 mg/kg) significantly reduced SD compared to the control group (P<0.05). The antiepileptic effect of β-alanine was more prominent during metestrus and diestrus than proestrus and estrus (P<0.05).
Conclusion: It seems β-alanine has antiepileptic effects which are more prominent during proestrus and estrus than metestrus and diestrus.
نوع مطالعه: مقاله پژوهشی |
موضوع مقاله:
Pharmacology
دریافت: 1402/8/9 | پذیرش: 1403/10/12 | انتشار: 1403/7/28
دریافت: 1402/8/9 | پذیرش: 1403/10/12 | انتشار: 1403/7/28
| بازنشر اطلاعات | |
 |
این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است. |
