یکشنبه 18 خرداد 1404
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دوره 32، شماره 154 - ( 7-1403 )
جلد 32 شماره 154 صفحات 369-361 |
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Mohammadi N, Eslami B, Seyedalipour B, Joz Jalalian E. The rs739837 Polymorphism of Vitamin D Receptor Gene and Its Relationship with Type 2 Diabetes Mellitus in the Eastern Population of Mazandaran Province. J Adv Med Biomed Res 2024; 32 (154) :361-369
URL: http://journal.zums.ac.ir/article-1-7413-fa.html
URL: http://journal.zums.ac.ir/article-1-7413-fa.html
The rs739837 Polymorphism of Vitamin D Receptor Gene and Its Relationship with Type 2 Diabetes Mellitus in the Eastern Population of Mazandaran Province. Journal of Advances in Medical and Biomedical Research. 1403; 32 (154) :361-369
چکیده: (343 مشاهده)
Background & Objective: The relationship between vitamin D receptor (VDR). Polymorphisms, and diabetes remain uncertain. This study aimed to examine the potential correlation between type 2 diabetes mellitus (T2DM) and rs739837 single nucleotide polymorphism (SNP) in the Mazandaran province population.
Materials & Methods: A case-control study was conducted, involving 100 individuals diagnosed with T2DM and 100 healthy controls, all residents of Mazandaran province. The extraction of genomic DNA and rs739837 polymorphism was genotyped using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method.
Results: The data indicated a significant association between GT genotype and a decreased risk of T2DM (OR= 0.5135, 95%CI= 0.2759 to 0.9559, P=0.0355). Moreover, individuals carrying T allele showed a reduced likelihood of progressing T2DM (OR= 0.4657, 95%CI= 0.2564 to 0.8461, P=0.0121).
Conclusion: The findings suggested that rs739837 polymorphism in the VDR gene may serve as a protective factor against T2DM in the studied population. Further research with larger samples is needed to confirm these results across different populations.
Materials & Methods: A case-control study was conducted, involving 100 individuals diagnosed with T2DM and 100 healthy controls, all residents of Mazandaran province. The extraction of genomic DNA and rs739837 polymorphism was genotyped using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method.
Results: The data indicated a significant association between GT genotype and a decreased risk of T2DM (OR= 0.5135, 95%CI= 0.2759 to 0.9559, P=0.0355). Moreover, individuals carrying T allele showed a reduced likelihood of progressing T2DM (OR= 0.4657, 95%CI= 0.2564 to 0.8461, P=0.0121).
Conclusion: The findings suggested that rs739837 polymorphism in the VDR gene may serve as a protective factor against T2DM in the studied population. Further research with larger samples is needed to confirm these results across different populations.
نوع مطالعه: مقاله پژوهشی |
موضوع مقاله:
Medical Biology
دریافت: 1402/9/29 | پذیرش: 1403/10/11 | انتشار: 1403/7/28
دریافت: 1402/9/29 | پذیرش: 1403/10/11 | انتشار: 1403/7/28
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