شنبه 17 خرداد 1404
[Archive]
دوره 32، شماره 154 - ( 7-1403 )
جلد 32 شماره 154 صفحات 377-370 |
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Ethics code: IR.BUMS.REC.1396.130
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Nasseri S, Vafaeie F, Miri-Moghaddam E. Genetic Polymorphism of 21 Autosomal Short Tandem Repeat Markers in South Khorasan Province of Iran. J Adv Med Biomed Res 2024; 32 (154) :370-377
URL: http://journal.zums.ac.ir/article-1-7457-fa.html
URL: http://journal.zums.ac.ir/article-1-7457-fa.html
Genetic Polymorphism of 21 Autosomal Short Tandem Repeat Markers in South Khorasan Province of Iran. Journal of Advances in Medical and Biomedical Research. 1403; 32 (154) :370-377
چکیده: (315 مشاهده)
Background: Short tandem repeats (STR) are highly polymorphic genetic markers widely used in human identification. This study aimed to investigate the genetic characteristics of 21 autosomal STR loci in individuals from eastern Iran.
Methods: Sixty healthy volunteers from twenty families provided buccal samples for analysis using the PowerPlex® 21 System. Various genetic and forensic parameters, including polymorphic information content, random matching probability, allelic discrimination power, paternity index, and exclusion power, were assessed.
Results: Five STR markers (D1S1656, D6S1043, D12S391, Penta D, and Penta E) were identified as prevalent in the eastern Iranian population, enabling successful parentage verification. All loci were in Hardy-Weinberg equilibrium, with a total of 178 alleles detected. The Penta E locus had the highest number of alleles, while TPOX had the most frequent allele. D12S391 exhibited the highest heterozygosity percentage (96.7%) among the loci analyzed.
Conclusion: The study confirmed the high informativeness of the 20 autosomal STR markers in individuals from eastern Iran, supporting previous findings. These results contribute to the genetic characterization of the eastern Iranian population and highlight the utility of these markers in forensic applications.
Methods: Sixty healthy volunteers from twenty families provided buccal samples for analysis using the PowerPlex® 21 System. Various genetic and forensic parameters, including polymorphic information content, random matching probability, allelic discrimination power, paternity index, and exclusion power, were assessed.
Results: Five STR markers (D1S1656, D6S1043, D12S391, Penta D, and Penta E) were identified as prevalent in the eastern Iranian population, enabling successful parentage verification. All loci were in Hardy-Weinberg equilibrium, with a total of 178 alleles detected. The Penta E locus had the highest number of alleles, while TPOX had the most frequent allele. D12S391 exhibited the highest heterozygosity percentage (96.7%) among the loci analyzed.
Conclusion: The study confirmed the high informativeness of the 20 autosomal STR markers in individuals from eastern Iran, supporting previous findings. These results contribute to the genetic characterization of the eastern Iranian population and highlight the utility of these markers in forensic applications.
نوع مطالعه: مقاله پژوهشی |
موضوع مقاله:
Life Science
دریافت: 1402/12/23 | پذیرش: 1403/10/13 | انتشار: 1403/7/28
دریافت: 1402/12/23 | پذیرش: 1403/10/13 | انتشار: 1403/7/28
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