جمعه 10 بهمن 1404
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دوره 33، شماره 161 - ( 9-1404 )
جلد 33 شماره 161 صفحات 4-4 |
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Jha A K, Almoyad M A A, Wahab S, Gupta G, Goh K W, Sahebkar A et al . Computational Identification of Dysregulated Genes and Pathways in Non-Small Cell Lung Cancer: A Systems Biology Approach. J Adv Med Biomed Res 2025; 33 (161) :4-4
URL: http://journal.zums.ac.ir/article-1-7825-fa.html
URL: http://journal.zums.ac.ir/article-1-7825-fa.html
Computational Identification of Dysregulated Genes and Pathways in Non-Small Cell Lung Cancer: A Systems Biology Approach. Journal of Advances in Medical and Biomedical Research. 1404; 33 (161) :4-4
چکیده: (19 مشاهده)
Non-small cell lung cancer (NSCLC) is the most prevalent form of lung malignancy globally and remains a leading cause of cancer-related mortality. This study presents a systematic bioinformatics-based investigation aimed at identifying differentially expressed genes (DEGs) and potential therapeutic targets associated with NSCLC. Publicly available RNA expression datasets were analyzed using advanced in silico tools, including the enrichr() function from the GSEApy package and R statistical software (v4.3.1), to uncover molecular pathways involved in disease progression. Key oncogenic signaling pathways such as TGF-β signaling, Wnt/β-catenin, PI3K-AKT-mTOR, and MAPK were found to be significantly associated with genes including AGER, ANK3, CSTA, FGG, AGR2, BRCA1, HDAC1, miR-577, TRIM29, PIK3CA, and JNK. Pathway enrichment analysis further identified significant involvement in chronic myeloid leukemia, longevity regulation, thyroid hormone signaling, viral carcinogenesis, Epstein-Barr virus infection, and microRNAs in cancer. The correlation analysis revealed that TRIM29 was highly expressed in control samples, while AGR2 showed prominent expression in NSCLC samples. Additionally, HDAC1 and BRCA1 emerged as promising diagnostic biomarkers. These findings enhance our understanding of NSCLC pathogenesis and highlight novel molecular candidates for the development of more effective, personalized therapeutic strategies, potentially improving clinical outcomes for patients.
نوع مطالعه: مقاله پژوهشی |
موضوع مقاله:
Life Science
دریافت: 1404/5/25 | پذیرش: 1404/8/20 | انتشار: 1404/9/21
دریافت: 1404/5/25 | پذیرش: 1404/8/20 | انتشار: 1404/9/21
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این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است. |
