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Mirzaei B, Babaei R, Jalali M, Goli H R, Haghshenas M R, Hosseini N et al . Prevalence of Bacterial Isolates Related to the Meningitis and Bacteremia in two Hospitals During 2016-2017. J Adv Med Biomed Res 2022; 30 (139) :162-169
URL: http://journal.zums.ac.ir/article-1-6402-en.html
Prevalence of Bacterial Isolates Related to the Meningitis and Bacteremia in two Hospitals During 2016-2017
Bahman Mirzaei * 1, Ryhaneh Babaei2 , Maryam Jalali2 , Hamid Reza Goli2 , Mohammad Reza Haghshenas2 , Negin Hosseini3 , Ebrahim Shafaie4
1- Dept. of Medical Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran , dr.bahman.m@gmail.com
2- Dept. of Medical Microbiology and Virology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3- Dept. of Medical Microbiology and Virology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
4- Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
Abstract:   (93765 Views)

Background and Objective: Hospitals niche as a source and repository for microbial infections are playing a significant role in the health of hospitalized patients. Bacteria are playing an essential role in human and animal blood infections and meningitis. The prevalence of bacterial agents and their susceptibility patterns are fundamental goals of current research.
Materials and Methods: Sampling was carried out in two main educational hospitals, Sari City, Iran, from April 2016 to March 2017. After traditional biochemical tests, susceptibility testing of isolates was performed taking advantage of Kerby-Bauer. Subsequently, the frequency of related bacterial agents to meningitis and bacteremia and their susceptibility patterns were analyzed.
Results: Frequencies of bacterial isolates in Bouali and Imam Hospitals for meningitis (1.9%, 3.5%), bacteremia (31.9%, 26.3%), and urinary tract infection (UTI) were screened (66.2%, 70.1%). Staphylococcus aureus (41.7%) and Streptococcus pneumoniae (45%) were the highest isolates of meningitis in the mentioned hospital. These values to bacteremia were as follows: Gram-negative Staphylococci (30.7%), Escherichia coli (30%). Coagulase- negative Staphylococci isolates recovered from meningitis were completely sensitive to ciprofloxacin and Gentamycin. In addition, P. aeruginosa, Klebsiella and Acinetobacter spp showed higher than 90% resistance against ampicillin. E. coli, Klebsiella spp and S. aureus showed 100% resistance to amoxiclav; while Klebsiella spp were completely sensitive to amoxiclav.
Conclusion: Given the bacterial isolates detected from hospital wards and following the findings prompt diagnosis method is essential to control infections and the proper use of effective antibiotics.

Keywords: Antibiotic resistance pattern, Meningitis, Bacteremia, Hospital-acquired infections
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✅ Given the bacterial isolates detected from hospital wards and following the findings prompt diagnosis method is essential to control infections and the proper use of effective antibiotics.


Type of Study: Original Article | Subject: Medical Biology
Received: 2021/01/27 | Accepted: 2021/04/13 | Published: 2022/01/31
References
1. Farzianpour F, Bakhtiari A, Mosavee SH, Akbarzadeh A. The most important species of nosocomial infection and the most important wards susceptible to nosocomial infection. Iran. J. Public Health. 2014:1016-7.
2. Bergogne-Berezin E, Towner K. Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features. Clin Microbiol Rev. 1996;9(2):148. [DOI:10.1128/CMR.9.2.148] [PMID] [PMCID]
3. Dent LL, Marshall DR, Pratap S, Hulette RB. Multidrug resistant Acinetobacter baumannii: a descriptive study in a city hospital. BMC Infect. Dis.. 2010;10(1):196. [DOI:10.1186/1471-2334-10-196] [PMID] [PMCID]
4. Peleg AY, Seifert H, Paterson DL. Acinetobacter baumannii: emergence of a successful pathogen. Clin Microbiol Rev. 2008;21(3):538-82. [DOI:10.1128/CMR.00058-07] [PMID] [PMCID]
5. Zavascki AP, Carvalhaes CG, Picao RC, Gales AC. Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii: resistance mechanisms and implications for therapy. Expert Rev. Anti-Infect.. 2010;8(1):71-93. [DOI:10.1586/eri.09.108] [PMID]
6. Assegu Fenta D, Lemma K, Tadele H, Tadesse BT, Derese B. Antimicrobial sensitivity profile and bacterial isolates among suspected pyogenic meningitis patients attending at Hawassa University Hospital: Cross-sectional study. BMC Microbiol.. 2020;20:1-10. [DOI:10.1186/s12866-020-01808-5] [PMID] [PMCID]
7. Manafi A, Kohanteb J, Mehrabani D, et al. Active immunization using exotoxin A confers protection against Pseudomonas aeruginosa infection in a mouse burn model. BMC Microbiol. 2009;9(1):1-5. [DOI:10.1186/1471-2180-9-23] [PMID] [PMCID]
8. Cheesbrough M. District laboratory practice in tropical countries, part 2: Cambridge university press; 2006. [DOI:10.1017/CBO9780511543470] [PMCID]
9. Ajello GW, Feeley JC, Hayes PS, et al. Trans-isolate medium: a new medium for primary culturing and transport of Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae. J. Clin. Microbiol. 1984;20(1):55-8. [DOI:10.1128/jcm.20.1.55-58.1984] [PMID] [PMCID]
10. Atlas RM. Handbook of microbiological media: CRC press; 2010. [DOI:10.1201/EBK1439804063]
11. Forbes BA, Sahm DF, Weissfeld AS. Study Guide for Bailey and Scott's Diagnostic Microbiology-E-Book: Elsevier Health Sciences; 2016.
12. Taheri J, Maleki Z, Oosla M, Falah F. The relationship between halitosis and gram-negative anaerobic bacteria in oral cavity. 2005. J Dental School Shahid Beheshti Univ Med Sci 22(4); 633- 43.
13. CLSI C. Performance standards for antimicrobial susceptibility testing. Clinical Lab Standards Institute. 2016.
14. Klevens RM, Edwards JR, Richards Jr CL, et al. Estimating health care-associated infections and deaths in US hospitals, 2002. Public Health Rep. 2007;122(2):160-6. [DOI:10.1177/003335490712200205] [PMID] [PMCID]
15. Davoudi AR, Najafi N, Shirazi MH, Ahangarkani F. Frequency of bacterial agents isolated from patients with nosocomial infection in teaching hospitals of Mazandaran University of Medical Sciences in 2012. Caspian J Intern Med. 2014;5(4):227.
16. Zahedi M, Abounoori M, Maddah MM, et al. Evaluation of bacterial nosocomial infections and antibiotic resistance pattern: A 2-year Epidemiological Surveillance Study in a Hospital Population. J Med Invest.. 2019;8(3):91-103.
17. Bennett JE, Dolin R. Mandell, Douglas, and Bennett's principles and practice of infectious diseases. 1999.
18. Wenger JD, Hightower AW, Facklam RR, Gaventa S, Broome CV, Group BMS. Bacterial meningitis in the United States, 1986: report of a multistate surveillance study. Int J Infect Dis,1990;162(6):1316-23. [DOI:10.1093/infdis/162.6.1316] [PMID]
19. Gold R. Bacterial meningitis. Am J Med. 1993;28:98-102.
20. Olarte L, Barson WJ, Barson RM, et al. Impact of the 13-valent pneumococcal conjugate vaccine on pneumococcal meningitis in US children. Clin. Infect. Dis.. 2015;61(5):767-75. [DOI:10.1093/cid/civ368] [PMID]
21. Yousefi MR, Hashemi H, Shams S. Study of bacterial agents of meningitis in children and detection of antibiogram patterns in Hamadan. Yafte ;2004, 5(2): 31-39
22. Horcajada JP, Soto S, Gajewski A, et al. Quinolone-resistant uropathogenic Escherichia coli strains from phylogenetic group B2 have fewer virulence factors than their susceptible counterparts. J. Clin. Microbiol.. 2005;43(6):2962-4. [DOI:10.1128/JCM.43.6.2962-2964.2005] [PMID] [PMCID]
23. Nikoonejad A, Gharabaghi N, Davari M, Ayremloo M, Nejad Rahim R. Sensitivity pattern and resistance against antibiotics in isolated microorganisms of hospitalized patients. J Urmia Univ Med Sci. 2013;24(10):785-90.
24. Sarangi KK, Pattnaik D, Mishra SN, Nayak MK, Jena J. Bacteriological profile and antibiogram of blood culture isolates done by automated culture and sensitivity method in a neonatal intensive care unit in a tertiary care hospital in Odisha, India. Int J Adv Med. 2015;2(4):387-92. [DOI:10.18203/2349-3933.ijam20151015]
25. Mehdinejad M, Khosravi A, Morvaridi A. Study of prevalence and antimicrobial susceptibility pattern of bacteria isolated from blood cultures. J. Biol. Sci.. 2009;9(3):249-53. [DOI:10.3923/jbs.2009.249.253]
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