Volume 31, Issue 148 (September & October 2023)                   J Adv Med Biomed Res 2023, 31(148): 507-511 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
KarimiFard M, Shafiepour M, Jamshidi M. Primary Hyperparathyroidism Associated with Recurrent Acute Pancreatitis: A Case Report. J Adv Med Biomed Res 2023; 31 (148) :507-511
URL: http://journal.zums.ac.ir/article-1-7076-en.html
Primary Hyperparathyroidism Associated with Recurrent Acute Pancreatitis: A Case Report
Maryam KarimiFard * 1, Mohammadreza Shafiepour2 , Mahdieh Jamshidi2
1- Dept. of Internal Medicine, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran , karimifardmaryam6@gmail.com
2- Dept. of Internal Medicine, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Abstract:   (1109 Views)

The association between recurrent acute pancreatitis and primary hyperparathyroidism (PHPT) is uncommon. We report the case of a 45-year-old woman who presented with recurrent episodes of acute pancreatitis. After the second episode of pancreatitis, she was diagnosed with primary hyperparathyroidism. Interestingly, she had no additional risk factors for pancreatitis. However, a year after successful parathyroid surgery, she showed no symptoms of pancreatitis and her serum levels of parathyroid hormone (PTH) and calcium remained within normal ranges. Primary hyperparathyroidism can manifest as acute pancreatitis due to hypercalcemia. Therefore, we recommend monitoring the serum calcium levels in patients diagnosed with acute pancreatitis. Appropriate diagnostic and therapeutic interventions should be undertaken for primary hyperparathyroidism to prevent the recurrence of pancreatitis and hypercalcemia.

Keywords: Pancreatitis, Primary hyperparathyroidism, Parathyroid hormone
Full-Text [PDF 423 kb]   (838 Downloads) |   |   Full-Text (HTML)  (360 Views)  

✅ We report the case of a 45-year-old woman who presented with recurrent episodes of acute pancreatitis. Appropriate diagnostic and therapeutic interventions should be undertaken for primary hyperparathyroidism to prevent the recurrence of pancreatitis and hypercalcemia.


Type of Study: Case report | Subject: Clinical medicine
Received: 2023/02/22 | Accepted: 2023/07/7 | Published: 2023/10/29
References
1. Kasper D, Fauci A, Hauser S, Longo D, Jameson J, Loscalzo J. Harrison's principles of internal medicine, 19e. New York, NY, USA: McGraw-Hill; 2022.
2. Sadiq NM, Jagannathan S, Badireddy M. Hypercalcemia. Stat Pearls [Internet]. 2020.
3. Enofe I, Igenoza O, Osaghae O,et al. Hypercalcemia-related acute pancreatitis is associated with worse outcomes in patients hospitalized for acute pancreatitis: review of the national inpatient sample database. HPB. 2019;21:S89. [DOI:10.1016/j.hpb.2019.03.149]
4. Bhurwal A, Mutneja HR, Suarez S, et al. Hypercalcemia and acute pancreatitis: results of a Nationwide Study: 9. Am J Gastroenterol. 2018;113:S7. [DOI:10.14309/00000434-201810001-00009]
5. Ma YB, Hu J, Duan YF. Acute pancreatitis connected with hypercalcemia crisis in hyperparathyroidism: A case report. World J Clin Case. 2019;7(16):2367. [DOI:10.12998/wjcc.v7.i16.2367] [PMID] [PMCID]
6. Bansal S, Kaushik RM, Kaushik R, Modi S, Raghuvanshi S, Kusum A. Primary hyperparathyroidism presenting as severe hypercalcemia with acute pancreatitis in pregnancy. Gynecol Endocrinol. 2020;36(5):469-72. [DOI:10.1080/09513590.2019.1698028] [PMID]
7. Yang L, Lin Y, Zhang XQ, Liu B, Wang JY. Acute pancreatitis with hypercalcemia caused by primary hyperparathyroidism associated with paraneoplastic syndrome: A case report and review of literature. World J Clin Case. 2021;9(29):8906. [DOI:10.12998/wjcc.v9.i29.8906] [PMID] [PMCID]
8. Silverberg SJ, Clarke BL, Peacock M, et al. Current issues in the presentation of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop. J Clin Endocrinol Metab. 2014;99(10):3580-94. [DOI:10.1210/jc.2014-1415] [PMID] [PMCID]
9. Bilezikian JP, Cusano NE, Khan AA, Liu JM, Marcocci C, Bandeira F. Primary hyperparathyroidism. Nature Rev Dis Prim. 2016;2(1):1-6. [DOI:10.1038/nrdp.2016.33] [PMID] [PMCID]
10. Ziegler R. Hypercalcemic crisis. J Am Soc Nephrol. 2001;12(suppl 1):S3-9. [DOI:10.1681/ASN.V12suppl_1s3]
11. Singh DN, Gupta SK, Kumari N, et al. Primary hyperparathyroidism presenting as hypercalcemic crisis: twenty-year experience. Indian J Endocrinol Metab. 2015;19(1):100. [DOI:10.4103/2230-8210.131763] [PMID] [PMCID]
12. Walker MD, Silverberg SJ. Primary hyperparathyroidism. Nature Rev Endocrinol. 2018;14(2):115-25. [DOI:10.1038/nrendo.2017.104] [PMID] [PMCID]
13. Cappell MS. Acute pancreatitis: etiology, clinical presentation, diagnosis, and therapy. Med Clin North Am. 2008;92(4):889-923. [DOI:10.1016/j.mcna.2008.04.013] [PMID]
14. Türkvatan A, Erden A, Türkoğlu MA, Seçil MU, Yüce G. Imaging of acute pancreatitis and its complications. Part 2: complications of acute pancreatitis. Diag Intervent Imag. 20151;96(2):161-9. [DOI:10.1016/j.diii.2013.12.018] [PMID]
15. Türkvatan A, Erden A, Turkoglu MA, Seçil MU, Yener Ö. Imaging of acute pancreatitis and its complications. Part 1: acute pancreatitis. Diag Intervent Imag. 2015;96(2):151-60. [DOI:10.1016/j.diii.2013.12.017] [PMID]
16. Bhatia M, Wong FL, Cao Y, et al. Pathophysiology of acute pancreatitis. Pancreatol. 2005;5(2-3):132-44. [DOI:10.1159/000085265] [PMID]
17. Frick TW, Mithöfer K, Fernández-del Castillo C, Rattner DW, Warshaw AL. Hypercalcemia causes acute pancreatitis by pancreatic secretory block, intracellular zymogen accumulation, and acinar cell injury. Am J Surg. 1995;169(1):167-72. [DOI:10.1016/S0002-9610(99)80127-5] [PMID]
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Advances in Medical and Biomedical Research

Designed & Developed by : Yektaweb