Volume 31, Issue 148 (September & October 2023)                   J Adv Med Biomed Res 2023, 31(148): 441-448 | Back to browse issues page

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Nasiri S M, Habibi S A H, Rohani M, Sedaghat A, Goudarzi S. Investigating Nerve Fiber Layer and Retinal Ganglion Layer Cells in Patients with Essential Tremor. J Adv Med Biomed Res 2023; 31 (148) :441-448
URL: http://journal.zums.ac.ir/article-1-7100-en.html
Investigating Nerve Fiber Layer and Retinal Ganglion Layer Cells in Patients with Essential Tremor
Seyedeh Mahnaz Nasiri1 , Seyed Amir Hassan Habibi * 2, Mohammad Rohani1 , Ahad Sedaghat3 , Sepideh Goudarzi4
1- Dept. of Neurology, Rasool Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2- Dept. of Neurology, Rasool Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran , Habibi.sah@iums.ac.ir
3- Dept. of Ophtalmology, Rasool Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
4- Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (1271 Views)

Background and Objective: Based on literatures, the patients with essential tremor have a thinner Retinal Nerve Fiber Layer (RNFL) layer in Optical Coherence Tomography (OCT) imaging, compared to the healthy population. Thus, we decided to examine the ocular-neural state of patients with essential tremor, by examining RNFL and Retinal Ganglion Cell Layer (RGCL) in the OCT reports of patients referred to Hazrat Rasool Akram Hospital in the years 2020 to 2022.
Materials and Methods: This research was implemented in the form of case-control study.50 patients were recruited into each group of tremor, and healthy controls. OCT parameters, including thickness of RNFL and RGCL were evaluated and recorded.
Results: The study findings revealed a significant difference in the mean superior, superior nasal, superior temporal sections of the right eye and superior temporal and inferior temporal regions of the left eye in RNFL between the control group and all patients (P < 0.01). Moreover, the results showed that there was a significant difference in the GCL in superior 6 mm of the right and left eye between the control group, and all patients (P <0.01).
Conclusion: Regarding the results this study, it seems that patients with essential tremor have a significant decrease in some RNFL and GCL factors compared to healthy people. However, the majority of variables examined from RNFL and GCL in our study did not show significant differences. Moreover, this thinning could be associated with the neurodegenerative nature of the disease.

Keywords: Essential Tremor, Optical Coherence Tomography, Retinal Ganglion Cell Layer, Retinal Nerve Fiber Layer
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✅ Regarding the results this study, it seems that patients with essential tremor have a significant decrease in some RNFL and GCL factors compared to healthy people. However, the majority of variables examined from RNFL and GCL in our study did not show significant differences. Moreover, this thinning could be associated with the neurodegenerative nature of the disease.


Type of Study: Original Article | Subject: Clinical medicine
Received: 2023/01/17 | Accepted: 2023/04/24 | Published: 2023/10/29
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