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Volume 32, Issue 151 (March & April 2024)
J Adv Med Biomed Res 2024, 32(151): 101-110 |
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Bassami F, Chiti H, Besharati Kivi S, Mohammadian F, Paknejad A, Fallah R. Correlation of Adverse Pregnancy Outcomes with Postpartum Thyroid Function and Autoimmunity Status in Euthyroid Women. J Adv Med Biomed Res 2024; 32 (151) :101-110
URL: http://journal.zums.ac.ir/article-1-7296-en.html
URL: http://journal.zums.ac.ir/article-1-7296-en.html
Fattaneh Bassami1 
, Hossein Chiti * 2, Shahin Besharati Kivi3 , Farnaz Mohammadian , Aisa Paknejad1 , Ramezan Fallah4
, Hossein Chiti * 2, Shahin Besharati Kivi3 , Farnaz Mohammadian , Aisa Paknejad1 , Ramezan Fallah4
1- Department of Internal Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
2- Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran ,h.chiti@yahoo.com
3- Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
4- 4. Department of Statistics and Epidemiology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
2- Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran ,
3- Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
4- 4. Department of Statistics and Epidemiology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Abstract: (275 Views)
Background&Objective:Occurrence of maternal or fetal complications during pregnancy may be related to development of postpartum thyroid dysfunction based on the underlying thyroid autoimmune status. The purpose of this study wasto investigate the incidence of thyroid dysfunction after delivery in euthyroid mothers who have experienced adverse pregnancy outcomes.
Materials&Methods: Among 387 euthyroid pregnant women, 118 experienced adverse pregnancy outcomes out of which only 96 subjects completed the study. The level of thyroperoxidase antibody in the first week after delivery and thyroid function tests including Total T4, T3RU and TSH three months after delivery were measured by electrochemiluminescence immunoassay method. SPSS version 22 was used to analyze the data and the significance level was defined as p<0.05.
Results:Thyroperoxidase antibody was positive in 14 participants (14.6%). Overall maternal and fetal complications in the group with positive thyroperoxidase antibody were more than the group without this antibody (p<0.001). Total T4 level was significantly (p=0.02) higher in the group with negative thyroperoxidase antibody (8.03±1.91) comparing with the positive antibody group (6.72±1.96). Overt hypothyroidism was the only thyroid dysfunction that had a significant relationship with thyroid autoimmune status three months after delivery (p=0.02).
Conclusion:This study indicates the possible occurrence of thyroid dysfunction after delivery in euthyroid mothers who have experienced maternal or fetal pregnancy complications.
Materials&Methods: Among 387 euthyroid pregnant women, 118 experienced adverse pregnancy outcomes out of which only 96 subjects completed the study. The level of thyroperoxidase antibody in the first week after delivery and thyroid function tests including Total T4, T3RU and TSH three months after delivery were measured by electrochemiluminescence immunoassay method. SPSS version 22 was used to analyze the data and the significance level was defined as p<0.05.
Results:Thyroperoxidase antibody was positive in 14 participants (14.6%). Overall maternal and fetal complications in the group with positive thyroperoxidase antibody were more than the group without this antibody (p<0.001). Total T4 level was significantly (p=0.02) higher in the group with negative thyroperoxidase antibody (8.03±1.91) comparing with the positive antibody group (6.72±1.96). Overt hypothyroidism was the only thyroid dysfunction that had a significant relationship with thyroid autoimmune status three months after delivery (p=0.02).
Conclusion:This study indicates the possible occurrence of thyroid dysfunction after delivery in euthyroid mothers who have experienced maternal or fetal pregnancy complications.
Type of Study: Original Article |
Subject:
Clinical medicine
Received: 2023/07/19 | Accepted: 2023/12/31 | Published: 2024/03/2
Received: 2023/07/19 | Accepted: 2023/12/31 | Published: 2024/03/2
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