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Volume 32, Issue 151 (March & April 2024)
J Adv Med Biomed Res 2024, 32(151): 127-134 |
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Jahantigh M, Bameri Z. Determining the Antibiotic Resistance of Staphylococcus aureus Strains Isolated from Patients Hospitalized in Zahedan, Southeastern Iran. J Adv Med Biomed Res 2024; 32 (151) :127-134
URL: http://journal.zums.ac.ir/article-1-7306-en.html
URL: http://journal.zums.ac.ir/article-1-7306-en.html
1- Infectious diseases and tropical medicine research center, Zahedan university of medical sciences , mojdehjahantigh001@gmail.com
2- Infectious diseases and tropical medicine research center, Zahedan university of medical sciences
2- Infectious diseases and tropical medicine research center, Zahedan university of medical sciences
Abstract: (220 Views)
Background & Objective: Staphylococcus aureus is one of the most important public health risks as it causes many forms of infection. Treatment options for infections caused by this pathogen are limited due to the development of resistance to commonly used antibiotics. This study aimed to investigate the antibiotic resistance patterns in Staphylococcus aureus strains.
Materials & Methods: In this cross-sectional study conducted between 2020 and 2023, 348 Staphylococcus aureus specimens were isolated from clinical samples at Aliebne Abitaleb Hospital in Zahedan, Iran. Following the identification of the strains, their antibiotic resistance to eight antibiotics was assessed by the disk diffusion method based on Clinical Laboratory Standard Institute 2022, and the MRSA isolates were screened. Additionally, Vancomycin's MIC was evaluated using the E-test. Statistical analysis was conducted using the chi-square test using SPSS, version 16 (IBM SPSS, Armonk, NY, USA).
Results: Of the 348 isolated S. aureus strains (171 from males and 177 from females), 163 (50%) were from blood cultures, and 53 (15.2%) were from tracheal samples. The strains showed the highest resistance to erythromycin (77.9%) and penicillin (100%). The samples had the lowest resistance to cotrimoxazole (36.2%) and nitrofurantoin (29.6%). Additionally, all strains were susceptible to vancomycin.
In this study, 76% and 30% of the examined strains could be classified as MDR and XDR, respectively. There was no significant association between age, gender, and MRSA infection (P > 0.05).
Conclusion: In this study, cotrimoxazole showed considerable activity against MRSA strains. Moreover, since all isolates were susceptible to vancomycin, this antibiotic could be the primary treatment choice. The high prevalence of MDR strains is a significant cause for concern.
Materials & Methods: In this cross-sectional study conducted between 2020 and 2023, 348 Staphylococcus aureus specimens were isolated from clinical samples at Aliebne Abitaleb Hospital in Zahedan, Iran. Following the identification of the strains, their antibiotic resistance to eight antibiotics was assessed by the disk diffusion method based on Clinical Laboratory Standard Institute 2022, and the MRSA isolates were screened. Additionally, Vancomycin's MIC was evaluated using the E-test. Statistical analysis was conducted using the chi-square test using SPSS, version 16 (IBM SPSS, Armonk, NY, USA).
Results: Of the 348 isolated S. aureus strains (171 from males and 177 from females), 163 (50%) were from blood cultures, and 53 (15.2%) were from tracheal samples. The strains showed the highest resistance to erythromycin (77.9%) and penicillin (100%). The samples had the lowest resistance to cotrimoxazole (36.2%) and nitrofurantoin (29.6%). Additionally, all strains were susceptible to vancomycin.
In this study, 76% and 30% of the examined strains could be classified as MDR and XDR, respectively. There was no significant association between age, gender, and MRSA infection (P > 0.05).
Conclusion: In this study, cotrimoxazole showed considerable activity against MRSA strains. Moreover, since all isolates were susceptible to vancomycin, this antibiotic could be the primary treatment choice. The high prevalence of MDR strains is a significant cause for concern.
Type of Study: Original Article |
Subject:
Clinical medicine
Received: 2023/08/1 | Accepted: 2024/01/13 | Published: 2024/03/2
Received: 2023/08/1 | Accepted: 2024/01/13 | Published: 2024/03/2
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