Volume 33, Issue 161 (November & December 2025)                   J Adv Med Biomed Res 2025, 33(161): 372-378 | Back to browse issues page

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Bijani B, Allami A, Nikoonejad A, Nazemsadati S. Life-Threatening Autonomic Dysregulation and Bulbar Neurological Deficits in Foodborne Botulism: A Case Report. J Adv Med Biomed Res 2025; 33 (161) :372-378
URL: http://journal.zums.ac.ir/article-1-7705-en.html
1- Department of Infectious Diseases, Clinical Research Development Unit, BuAliSina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
2- Department of Infectious Diseases, Clinical Research Development Unit, BuAliSina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran , allami9@yahoo.com
Abstract:   (230 Views)

This case report describes a 17-year-old female patient who presented with severe autonomic dysregulation and neurological symptoms. We explain in detail the patient's clinical course, diagnostic evaluation, treatment, and follow-up, emphasizing the importance of early recognition and management of botulism. This case highlights the importance of public education on food safety practices to prevent future occurrences. The report also highlights the critical role of interdisciplinary collaboration in the management of complex cases involving multiple systems, such as the autonomic and neurological systems.

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Type of Study: Case Report Article | Subject: Clinical Medicine
Received: 2025/06/11 | Accepted: 2025/10/6 | Published: 2025/12/12

References
1. Mezencev R, Klement C. Foodborne botulism - a re-emerging public health challenge. Epidemiol Mikrobiol Imunol. 2017;66(1):39-48.
2. Rempel L, Malik RN, Shackleton C, Calderón-Juárez M, Sachdeva R, Krassioukov AV. From Toxin to Treatment: A Narrative Review on the Use of Botulinum Toxin for Autonomic Dysfunction. Toxins (Basel). 2024;16(2):96. [DOI:10.3390/toxins16020096] [PMID] [PMCID]
3. Kobaidze K, Wiley Z. Botulism in the 21st Century: A Scoping Review. Brown J Hosp Med. 2023;2(2):72707. [DOI:10.56305/001c.72707] [PMID] [PMCID]
4. Anniballi F, Auricchio B, Fiore A, Lonati D, Locatelli CA, Lista F, et al. Botulism in Italy, 1986 to 2015. Euro Surveill. 2017;22(24):30550. [DOI:10.2807/1560-7917.ES.2017.22.24.30550] [PMID] [PMCID]
5. Connan C, Popoff MR. Uptake of Clostridial Neurotoxins into Cells and Dissemination. Curr Top Microbiol Immunol. 2017;406:39-78. [DOI:10.1007/82_2017_50] [PMID]
6. Thompson J, Horowitz Z, Blumenberg A. Botulism. J Educ Teach Emerg Med. 2021;6(1):S1-s23. [DOI:10.5070/M561051827] [PMCID]
7. Min M, Bai L, Peng X, Guo L, Wan K, Qiu Z. An Outbreak of Botulinum Types A, B, and E Associated With Vacuum-Packaged Salted Fish and Ham. J Emerg Med. 2021;60(6):760-3. [DOI:10.1016/j.jemermed.2020.12.006] [PMID]
8. Bijani B, Allami A, Nikoonejad A. Botulism and Acidic Foods: A Case Report and Literature Review. Sci J Kurd Univ Med Sci. 2025;30(3):22-32.
9. Khorasan MR, Rahbar M, Bialvaei AZ, Gouya MM, Shahcheraghi F, Eshrati B. Prevalence, Risk Factors, and Epidemiology of Food-borne Botulism in Iran. J Epidemiol Glob Health. 2020;10(4):288-92. [DOI:10.2991/jegh.k.200517.001] [PMID] [PMCID]
10. Miceli G, Cassataro G, Volpe V, Fertitta E, Canale C, Tomaiuolo L, et al. Postprandial hypotension as a predictor of respiratory failure in patients with foodborne botulinum intoxication - a case-control study in outbreak investigation. Int J Infect Dis. 2023;136:111-4. [DOI:10.1016/j.ijid.2023.09.014] [PMID]
11. Eslambolchi A, Maliglig A, Gupta A, Gholamrezanezhad A. COVID-19 or non-COVID viral pneumonia: How to differentiate based on the radiologic findings?. World J Radiol. 2020;12(12):289-301. [DOI:10.4329/wjr.v12.i12.289] [PMID] [PMCID]
12. Agarwala P, Machnicki S, Ryu JH, Hu X, Saez K, Raoof S. Imaging of Aspiration: When to Suspect Based on Imaging of Bacterial Aspiration, Chemical Aspiration, and Foreign Body Aspiration. InSeminars in Respiratory and Critical Care Medicine. 2024. New York, NY, USA: Thieme Medical Publishers, Inc.. [DOI:10.1055/s-0044-1791740] [PMID]
13. Selickman J, Vrettou CS, Mentzelopoulos SD, Marini JJ. COVID-19-Related ARDS: Key Mechanistic Features and Treatments. J Clin Med. 2022;11(16):4896. [DOI:10.3390/jcm11164896] [PMID] [PMCID]
14. Rao AK. Clinical guidelines for diagnosis and treatment of botulism, 2021. MMWR Recomm Rep. 2021;70(2):1-30. [DOI:10.15585/mmwr.rr7002a1] [PMID] [PMCID]
15. Hoang LH, Nga TT, Tram NT, Trang LT, Ha HTT, Hoang TH, et al. First report of foodborne botulism due to Clostridium botulinum type A(B) from vegetarian home-canned pate in Hanoi, Vietnam. Anaerobe. 2022;77:102514. [DOI:10.1016/j.anaerobe.2022.102514] [PMID]

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