We are highly interested in the growing body of research demonstrating the beneficial role of platelets in wound healing. Platelets contribute to key processes such as hemostasis, cell transition regulation, and the release of cytokines and growth factors, which are vital for tissue repair. Advances using platelet derivatives like platelet-rich plasma and platelet gel have shown promising effects, including enhanced collagen production, antibacterial action, and reduced inflammation. Additionally, iron-chelating agents play an important role in tissue regeneration by promoting angiogenesis, preventing bacterial contamination, and reducing oxidative stress, making them valuable in wound rehabilitation.

Eltrombopag, an oral thrombopoietin receptor agonist approved for treating thrombocytopenia, has demonstrated multiple beneficial properties beyond its primary use. Acting as an antioxidant, iron chelator, and antimicrobial agent—particularly against Staphylococcus biofilms—Eltrombopag shows potential in preventing wound infections, a major hurdle in healing. This multifunctional mechanism combining platelet stimulation, antimicrobial effects, and iron chelation positions Eltrombopag as a promising novel therapy for wound healing. Although this potential remains underexplored, we advocate for further research into Eltrombopag’s therapeutic applications and hope our perspective will contribute to advancing innovation in this field.