Background and Objective: Atopy is an allergic state with manifestations of asthma, atopic dermatitis and allergic rhinitis. There was genetic tendency to atopy and the genetic polymorphisms in the TLRs had been shown as a causal factor. The aim of this study was to investigate the association between TLR2 rs7656411 polymorphisms and atopic people in Zanjan Province.
Material and Methods: Total genomic DNA was extracted from the whole blood of atopic and non-atopic individuals (100 atopic patients and 50 healthy control subjects) that randomly selected in Zanjan. PCR amplification and direct sequencing methods were used for genotyping of TLR2 rs7656411 in all patients and controls.
Results: In this study, the GG genotype was higher in the patients than controls (15% vs 8% in non-atopic subjects). However, there was not significant (P-value= 0.21). We also didn’t find any significant difference between the frequency of alleles (G and T) in the patients and controls.
Conclusion: Our study showed that TLR2 rs7656411 polymorphisms are not significantly associated with atopy in an Iranian population, but the GG genotype might be a risk factor for atopy.