Background and Objective: Upper gastro intestinal cancers are considered to be a global health problem and gastric cancer is the fourth common malignancy worldwide. In cancer patients, low levels of albumin,
C-reactive protein and platelets are considered as bad prognostic factors. The objective of this study was to evaluate the levels of Albumin (Alb), C-reactive protein (CRP), and Platelets in patients admitted to Endoscopy Unit of Vali-e-Asr Hospital in Zanjan in 2011-2012.

Materials and Methods: 308 patients who had been admitted for upper gasterointestinal endoscopy to Endoscopy Unit of Vali-e-Asr Hospital in Zanjan were entered into this study. Through the upper endoscopy of all abnormal lesions went through biopsy and pathological studies were followed.

Results: Patients were assigned to three groups of normal, benign and malignant lesions and their platelets, albumin levels, BMI and C-reactive protein were measured and compared as prognostic factors. The mean BMI, in the malignant group was significantly lower than the other two groups) PV=0.051(. The mean values of serum albumin in the malignant group was significantly lower than the other two groups (PV=0.023). Meanwhile, the average level of CRP and platelets in the malignant group was significantly higher than the other two groups.  

Conclusion: Due to the high prevalence of gastrointestinal malignancies in Iran, measurement of albumin, C-reactive protein and platelet levels can be an efficient approach to diagnose or prognosis in these diseases.