دوره 26، شماره 114 - ( 1-1397 )                   جلد 26 شماره 114 صفحات 115-106 | برگشت به فهرست نسخه ها

XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Tajmirali S, Setorki M, Hooshmandi Z. Analgesic Effect of Satureja bachtiarica Essential Oil on Mice Using Hot Plate and Tail Immersion Tests. J Adv Med Biomed Res 2018; 26 (114) :106-115
URL: http://journal.zums.ac.ir/article-1-4966-fa.html
تاجمیر عالی شمایل، سترکی محبوبه، هوشمندی زهرا. بررسی اثرات ضد دردی اسانس مرزه‌ی بختیاری به روش صفحه داغ و غوطه وری دم در موش کوچک آزمایشگاهی. Journal of Advances in Medical and Biomedical Research. 1397; 26 (114) :106-115

URL: http://journal.zums.ac.ir/article-1-4966-fa.html


1- دانشگاه آزاد اسلامی واحد ایذه ، ایذه
2- دانشگاه آزاد اسلامی واحد ایذه ، ایذه ، setorgi@gmail.com
3- دانشگاه آزاد اسلامی واحد سنندج، سنندج
چکیده:   (149719 مشاهده)

Background and Objective: Due to the numerous side effects of synthetic analgesics, attention has been paid to find new analgesic agents with fewer side effects. This study aimed to evaluate the analgesic properties of Satureja bachtiarica essential oil in mice.
Materials and Methods: In this study, eighty male NMRI mice were randomly assigned to 5 groups including a control group, groups receiving Satureja bachtiarica essential oil at doses of 25, 50 and 100 mg/kg and a group that received morphine at a dose of 10 mg/kg. After intraperitoneal injection of morphine and essential oil, pain response was determined using hot plate and tail immersion tests.
Results: In the hot plate test, 100 mg/kg of Satureja bachtiarica essential oil showed significant analgesic effect compared with the control group but, 50 and 25 mg/kg doses of essential oil did not  show any significant effect. Intraperitoneal injection of Satureja bachtiarica essential oil at a dose of 100 mg/kg increased resistance to the hot water at 0, 2, 4 and 6 minutes after the beginning of the tail immersion
test (P<0.05).
Conclusion: The results of this study showed the analgesic effect of Satureja bachtiarica essential oil on mice.

متن کامل [PDF 2914 kb]   (161024 دریافت)    
نوع مطالعه: کارآزمایی بالینی |
دریافت: 1396/9/26 | پذیرش: 1396/9/26 | انتشار: 1396/9/26

فهرست منابع
1. Haj HV, Ghannadi A, Sharif B. Anti-inflammatory and analgesic effects of Coriandrum sativum L. in animal models. J Shahrekord Univ Med Sc. 2003; 5: 8-15.
2. Sommer C, Kress M. Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neuroscience letters. 2004; 361: 184-7. [DOI:10.1016/j.neulet.2003.12.007] [PMID]
3. 3 -Dahl J, Kehlet H. Non-steroidal anti-inflammatory drugs: rationale for use in severe postoperative pain. Br J Anaesthesia. 1991; 66: 703-12. [DOI:10.1093/bja/66.6.703] [PMID]
4. Bovill J. Mechanisms of actions of opioids and non-steroidal anti-inflammatory drugs. Europe J Anaesthesiol. 1997; 14: 9-15. [DOI:10.1097/00003643-199705001-00003] [PMID]
5. Başer KHC. Investigation of Origanum onites, Sideritis congesta and Satureja cuneifolia essential oils for analgesic activity. Phytother Res. 1996; 10: 342-4. https://doi.org/10.1002/(SICI)1099-1573(199606)10:4<342::AID-PTR832>3.0.CO;2-W [DOI:10.1002/(SICI)1099-1573(199606)10:43.0.CO;2-W]
6. Delfan B, Hashemnia M, Javanbakht A, Nazari M, Jebreily R, Birjandi M. The effect of Satureja Khuzestanica essential oil on the pain of patients with PHN. Yafte. 2010; 11: 25-34.
7. Esmaeili S, Irani M, Moazzeni Zehan H, Keramatian B, Tavakoli Harandi Z, Hamzeloo-Moghadam M. Cytotoxic activity of some ethnic medicinal plants from southwest of Iran. J Pharmacognosy Res. 2016; 3: 43-7.
8. Nazari M, Monajemi R, Ghasemi Pirbalouti A, Jafarian Dehkordi M, Riahi Dehkordi M. Effects of essential oils of Thymus deanensis and Satureja bachtiarica on plasma lipoproteins in rats feeding with a fatty diet. J Herbal Drug. 2013; 3:243-8.
9. Hashemi MB, Niakousari M, Saharkhiz MJ. Antioxidant activity of Satureja bachtiarica Bunge essential oil in rapeseed oil irradiated with UV rays. Europ J Lipid Sci Technol. 2011; 113: 1132-7. [DOI:10.1002/ejlt.201000547]
10. Sefidkon F, ASKARI F, Sadeghzadeh L, Oulia P. Antimicrobial effects of the essential oils of Satureja mutica, S. edmondi and S. bachtiarica against Salmonella paratifi A and B. Iran J Biol. 2009; 22: 249-58.
11. Sefidkon F, Sadeghzadeh L, Teymouri M, Asgari F, Ahmadi S. Antimicrobial effects of the essential oils of two Satureja species (S. Khuzistanica Jamzad and S. bachtiarica Bunge) in two harvesting time. Iranian J Med Arom Plant. 2007; 23: 174-82.
12. Pourshab M, Karimi J, Abbasipour H, Ahadiyat A. Acaricidal effect of two plant essential oils Pimpinella anisum and Satureja bachtiarica on two-spotted spider mite Tetranychus urticae (Acari: Tetranychidae). J Entomol Res. 2008; 7: 289-98
13. Hajhashemi V, Ghannadi A, Pezeshkian SK. Antinociceptive and anti-inflammatory effects of Satureja hortensis L. extracts and essential oil. J Ethnopharmacol. 2002; 82: 83-7. [DOI:10.1016/S0378-8741(02)00137-X]
14. Rabiei Z, Moghtadaei M, Mokhtari S, Rafieian-Kopaei M. Atricaria chamomilla essential oil with physical training improves passive avoidance memory of Wistar rats. Ir J Physiol Pharmacol. 2016; 2: 104-96.
15. council NR. Guide for the care and use of laboratory animals: National Academies Press; 2010.
16. Hojati M, Moradi A, Rafieian Koupai M. Effect of various doses of Lavandula officinalis on acute pain in rat. Razi J Med Sci. 2015; 22: 115-21.
17. Rabiei Z, Rafieian-Kopaei M, Mokhtari S, Alibabaei Z, Shahrani M. The effect of pretreatment with different doses of Lavandula officinalis ethanolic extract on memory, learning and nociception. Bio Med Age Pathol. 2014; 4: 71-6. [DOI:10.1016/j.biomag.2013.10.006]
18. Sefidkon F, Jamzad Z. Essential oil of Satureja bachtiarica Bunge. J Essential Oil Res. 2000; 12: 545-6. [DOI:10.1080/10412905.2000.9712155]
19. Guimarães AG, Oliveira GF, Melo MS, et al. Bioassay‐guided evaluation of antioxidant and antinociceptive activities of carvacrol. Basic Clin pharmacol Toxicol. 2010; 107:949-57. [DOI:10.1111/j.1742-7843.2010.00609.x] [PMID]
20. Guimarães AG, Xavier MA, de Santana MT, et al. Carvacrol attenuates mechanical hypernociception and inflammatory response. Naunyn Schmiedeberg's Arch Pharmacol. 2012; 385: 253-63. [DOI:10.1007/s00210-011-0715-x] [PMID]
21. Passos FFdB, Lopes EM, de Araújo JM, et al. Involvement of cholinergic and opioid system in γ-terpinene-mediated antinociception. Evid Based Complement Alter. 2015; 2015. [DOI:10.1155/2015/829414] [PMID] [PMCID]
22. Ito S, Okuda-Ashitaka E, Minami T. Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin. Neuro Sci Res. 2001; 41: 299-332. [DOI:10.1016/S0168-0102(01)00289-9]
23. Hosoi M, Oka T, Hori T. Prostaglandin E receptor EP 3 subtype is involved inthermal hyperalgesia through its actions in the preoptic hypothalamus and the diagonal band of Broca in rats. Pain. 1997; 71:303-11. [DOI:10.1016/S0304-3959(97)03380-0]
24. da Silva Lima M, Quintans-Júnior LJ, de Santana WA, Kaneto CM, Soares MBP, Villarreal CF. Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10. Europ J Pharmacol. 2013; 699: 112-7. [DOI:10.1016/j.ejphar.2012.11.040] [PMID]
25. de Oliveira Ramalho TR, de Oliveira MTP, de Araujo Lima AL, Bezerra-Santos CR, Piuvezam MR. Gamma-terpinene modulates acute inflammatory response in mice. Planta Medica. 2015; 81: 1248-54. [DOI:10.1055/s-0035-1546169] [PMID]
26. Fachini-Queiroz FC, Kummer R, Estevao-Silva CF, et al. Effects of thymol and carvacrol, constituents of Thymus vulgaris L. essential oil, on the inflammatory response. Evid Based Complement Alternat Med. 2012; 2012: Epub. [DOI:10.1155/2012/657026] [PMID] [PMCID]

ارسال پیام به نویسنده مسئول


بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به Journal of Advances in Medical and Biomedical Research می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2025 CC BY-NC 4.0 | Journal of Advances in Medical and Biomedical Research

Designed & Developed by : Yektaweb