دوره 26، شماره 116 - ( 5-1397 )                   جلد 26 شماره 116 صفحات 34-20 | برگشت به فهرست نسخه ها

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Mehri Alvar Y, Ramezani A, Gaeeni A A, Golab F, gheiratmand R, Barati M. The Effect of Eight Weeks of High-Intensity Interval Training on Gene Expression of Angiogenesis Factors in Ischemic Rats. J Adv Med Biomed Res 2018; 26 (116) :20-34
URL: http://journal.zums.ac.ir/article-1-5087-fa.html
مهری الوار یعقوب، رمضانی علیرضا، گاینی عباسعلی، گلاب فرشته، غیرتمند ریاض، براتی محمود. تاثیر هشت هفته تمرین تناوبی شدید بر بیان ژن عوامل رگ‌زایی در موش‌های صحرایی مبتلا به ایسکمی میوکارد. Journal of Advances in Medical and Biomedical Research. 1397; 26 (116) :20-34

URL: http://journal.zums.ac.ir/article-1-5087-fa.html

تاثیر هشت هفته تمرین تناوبی شدید بر بیان ژن عوامل رگ‌زایی در موش‌های صحرایی مبتلا به ایسکمی میوکارد
یعقوب مهری الوار*1 ، علیرضا رمضانی2 ، عباسعلی گاینی3 ، فرشته گلاب4 ، ریاض غیرتمند5 ، محمود براتی6
1- دانشجوی دکترای فیزیولوژی ورزشی، دانشکده‌ی علوم ورزشی، دانشگاه تربیت دبیر شهید رجایی، تهران
2- دکترای تخصصی فیزیولوژی، دانشیارگروه فیزیولوژی ورزشی، دانشکده‌ی علوم ورزشی، دانشگاه تربیت دبیر شهیدرجایی، تهران
3- دکترای تخصصی فیزیولوژی، استاد گروه فیزیولوژی ورزشی، دانشکده‌ی علوم ورزشی، دانشگاه تهران، تهران
4- دکترای تخصصی فیزیولوژی، استادیار مرکز تحقیقات سلولی و ملوکولی، دانشگاه علوم پزشکی ایران، تهران
5- متخصص قلب و عروق، گروه هماتولوژی کودکان، بیمارستان شهدا، دانشگاه علوم پزشکی شهید بهشتی، تهران
6- گروه بیوتکنولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی تهران، تهران
چکیده:   (161351 مشاهده)

Background and Objective: Myocardial infraction can lead to loss of heart muscle cell, changes in ventricular function and structure, scar formation as well as leading the heart to ultimate stroke and its loss. This study aimed to investigate the effect of eight weeks of High-Intensity Interval Training (HIIT) on the gene expression of angiogenesis factors in ischemic rats.
Materials and Methods: In this study, 28 male Wistar rats (200-250 g) were randomly assigned to 4 groups: sham, ischemia, exercise, and exercise-ischemia. Myocardial infarction (MI) was achieved via closure of LAD artery for 30 minutes. A treadmill exercise program was performed by the rats for 8 weeks, 40 minutes daily, 3 days a week.
Results: The results showed that there is a significant difference between the four groups in gene expression levels of VEGF, apelin and apelin receptor (p = 0.001). Results also showed that the gene expression level of VEGF, apelin and apelin receptor was significantly increased in the exercise-ischemia group compared to sham (p = 0.04), ischemia (p = 0.002) and exercise (p = 0.009) groups. Results showed that exercise during ischemia can lead to an increase in VEGF gene expression but not in exercise group alone. On the other hand, a significant increase was observed in gene expression level of apelin following ischemic intervention compared to the sham group (p = 0.025). No difference was observed between the interval training group and sham group (p > 0.05). Meanwhile, a significant reduction in the gene expression level of apelin receptor was seen following ischemic intervention compared to the sham group (p = 0.04).
Conclusion: The physiological adaptations caused by interval training are associated with different gene expressions. A regular interval training program leads to the increase of factors involved in angiogenesis and the regeneration of cardiac muscle vessels following myocardial ischemia.

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نوع مطالعه: کارآزمایی بالینی |
دریافت: 1396/12/12 | پذیرش: 1396/12/12 | انتشار: 1396/12/12
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