دوره 26، شماره 116 - ( 5-1397 )                   جلد 26 شماره 116 صفحات 110-100 | برگشت به فهرست نسخه ها

XML English Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Mansoriyan M, Torabzadeh Khorasani P, Ramezani M. Effect of Fluoxetine on Ovarian and Oviduct Tissue in Female Mature Balb/C Mice. J Adv Med Biomed Res 2018; 26 (116) :100-110
URL: http://journal.zums.ac.ir/article-1-5092-fa.html
منصوریان مهسا، تراب‌زاده خراسانی پروین، رمضانی مینا. ﺑﺮرﺳﻲ اﺛﺮ داروی ﻓﻠﻮﻛﺴﺘﻴﻦ ﺑﺮ روی بافت تخمدان و اوویداکت در موش سوری ماده بالغ C/Balb. Journal of Advances in Medical and Biomedical Research. 1397; 26 (116) :100-110

URL: http://journal.zums.ac.ir/article-1-5092-fa.html

ﺑﺮرﺳﻲ اﺛﺮ داروی ﻓﻠﻮﻛﺴﺘﻴﻦ ﺑﺮ روی بافت تخمدان و اوویداکت در موش سوری ماده بالغ C/Balb
مهسا منصوریان1 ، پروین تراب‌زاده خراسانی*2 ، مینا رمضانی3
1- کارشناس ارشد گروه زیست‌شناسی گرایش تکوین جانوری، دانشگاه آزاد اسلامی واحد کرج، کرج
2- دکترای تخصصی زیست شناسی، استادیار گروه زیست‌شناسی گرایش تکوین جانوری، دانشگاه آزاد اسلامی واحد کرج ، کرج ، p.torabzadeh@gmail.com
3- دکترای تخصصی زیست شناسی ، دانشیار گروه زیست‌شناسی (تکوین جانوری)، دانشگاه آزاد اسلامی واحد تهران مرکزی ، تهران
چکیده:   (161391 مشاهده)

Background and Objective: Use of antidepressants such as fluoxetine, which is widely used worldwide and easily accessible to the public, causes complications such as temporary or permanent infertility. The present study was conducted to investigate the effects of fluoxetine on the ovaries and oviducts of mature female Balb/C mice.
Materials and Methods: In this study after determining the appropriate dose of fluoxetine, it was injected intraperitoneally (IP) for 30 days into 75 adult Balb/C mice with doses of 15 mg/kg (group 1), 20 mg /kg (group 2), 25 mg /kg (group 3), control group (non-injection) and sham (distilled water injection). ANOVA analysis and Duncan test were used to compare the means with significant levels being considered (P<0.05) and (P <0.001).
Results: During macroscopic examination, significant ovary weight decrease was observed in all three doses
(P <0.001) and in microscopic studies, reduction of the small and large diameter, number of graph follicles and corpus luteum were observed (P <0.05 and P <0.001 respectively). Meanwhile, an increase in the number of degenerative follicles and damaged zona pellucidas was significant (P <0.001 and P <0.05), and oviduct diameter was significantly higher than the control group (P <0.05).
Conclusion: It can generally be concluded that fluoxetine has a damaging effect on ovarian and oviduct tissue of mice.

متن کامل [PDF 3064 kb]   (157547 دریافت)    
نوع مطالعه: کارآزمایی بالینی |
دریافت: 1396/12/12 | پذیرش: 1396/12/12 | انتشار: 1396/12/12
فهرست منابع
1. Hemayatkhah-Jahromi V, Forouzanfar M, Ebrahimian A. Effect of fluoxetine on hormonal axis of pituitary-gonad in adult female rats. J Kashan Univ Med Sci. 2014; 17: 517-21.
2. Hashemi SS, Jelodar GA, Rafati AR. Investigating the effects of fluoxetine on cortisol and thyroid hormone levels in rats. J Arak Univ Med Sci. 2014; 17: 82-89.
3. Guptarak J, Sarkar J, Hiegel C, Uphouse L. Role Of 5-Ht1a receptors in fluoxetine-induced lordosis inhibition. Horm Behav. 2010; 58: 290-6. [DOI:10.1016/j.yhbeh.2010.03.003] [PMID] [PMCID]
4. Klomp A, Va clavu L, Meerhoff GF, Reneman L, Lucassen PJ. Effects of chronic fluoxetine treatment on neurogenesis and tryptophan hydroxylase expression in adolescent and adult rats. PLoS ONE. 2014; 9: e97603. [DOI:10.1371/journal.pone.0097603] [PMID] [PMCID]
5. Hiegel C, Miryala C, Uphouse L. Sprague-dawley and fischer female rats differ in acute effects of fluoxetine on sexual behavio. J Sex Med. 2013; 10: 350-61. [DOI:10.1111/j.1743-6109.2012.02981.x] [PMID] [PMCID]
6. Eugenia Ö, CE V, Maria D. Fluoxetine effect on gestation and fetal development. Acta Medica Marisiensis. 2014; 60: 157-9. [DOI:10.2478/amma-2014-0034]
7. Mokhber N, Bordbar fayaz M, Javidan K. Fluoxetine treatment effects of premenstrual dysphoric syndrome. Quarter J Fundament Ment Health. 2004; 23: 111-15.
8. Rezakhaniha B, Khoshdel AR. Comparative study of therapeutic effects of two medicinal procedures of fluoxetine in premature ejaculation. J Army Univ Med Sci. 2011; 8: 299-304.
9. Altamura A, Moro A, Percudani M. Clinical pharmacokinetics of fluoxetine. Clin Phannacokinet. 1994; 26: 201-14. [DOI:10.2165/00003088-199426030-00004] [PMID]
10. Herizchi S, Ranjbar F, Bagheri F. Comparing of sexual side effects of sertraline, fluoxetine and citalopram in female patients. J Psych Beh Stud. 2015; 3: 356-66.
11. Frye A, Rhodes M. Fluoxetine-induced decrements in sexual responses of female rats and hamsters are reversed by 3α,5α-THP. J Sex Med. 2010; 7: 2670-80. [DOI:10.1111/j.1743-6109.2010.01814.x] [PMID] [PMCID]
12. Maswood N, Sarkar J, Uphouse L. Modest effects of repeated fluoxetine on estrous cyclicity and sexual behavior in sprague dawley female rats. Brain Res. 2008; 15; 1245: 52-60. [DOI:10.1016/j.brainres.2008.09.063] [PMID] [PMCID]
13. Abuhamdah RM, Hussain MD, Chazot PL, Ennaceur A. Effects of chronic fluoxetine treatment on anxious behaviour of BALB/c mice in a 3-dimensional maze. Stress. 2015; 18: 677-85. [DOI:10.3109/10253890.2015.1083550] [PMID]
14. Li Y, Chen L, Du Y, Huang D, Han H, Dong Z. Fluoxetine ameliorates atopic dermatitis-like skin lesions in balb/c mice through reducing psychological stress and inflammatory response. Front Pharmacol. 2016; 13; 7: 318. [DOI:10.3389/fphar.2016.00318]
15. Rafieian-kopaei M, Rabiei Z, Mokhtari Sh, Babaei F. Effect of kombucha tea on depression and motor activity in mice. JMP. 2017; 1: 156-66.
16. Rowlett JK, Birkett MA, Shinday NM, Kessler EJ, Meyer JS, Ritchie S. Acute anxiogenic-like effects of selective serotonin reuptake inhibitors are attenuated by the benzodiazepine diazepam in BALB/c mice. Pharmacol Biochem Behav. 2011; 98: 544-51. [DOI:10.1016/j.pbb.2011.03.006] [PMID] [PMCID]
17. Tupal S, Faingold CL. Evidence supporting a role of serotonin in modulation of sudden death induced by seizures in DBA/2 mice. Epilepsia. 2006; 47: 21-6. [DOI:10.1111/j.1528-1167.2006.00365.x] [PMID]
18. Alka A. Selective serotonin reuptake inhibitors (SSRIs) induced weight changes: A dose and duration dependent study on albino rats. Journal of Clinical and Diagnostic Research. 2016; 10: AF01-AF03.
19. Nematollahi M, Kookaram K, Forsatkar M. The effects of fluoxetine on food intake and dietary behavior in goldfish Carassius auratus. Iran J Fisherie. 2014; 23: 97-108.
20. Ebrahimian A, Pourahmad M, Kargar Jahromi H. The investigation into the effect of flouxetine on quantity of ovarian follicles in adult female rats. Biomed Pharmacol J. 2014; 7: 375-78. [DOI:10.13005/bpj/501]
21. Albright F, Smith PH, Fraser R. A syndrome characterized by primary ovarian insufficiency. Am J Med Sci. 1942; 204: 625-48. [DOI:10.1097/00000441-194211000-00001]
22. Welt CK. Primary ovarian insufficiency: a more accurate term for premature ovarian failure. Clin Endocrinol (Oxf). 2008; 68: 499-509. [DOI:10.1111/j.1365-2265.2007.03073.x] [PMID]
ارسال پیام به نویسنده مسئول

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به Journal of Advances in Medical and Biomedical Research می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2025 CC BY-NC 4.0 | Journal of Advances in Medical and Biomedical Research

Designed & Developed by : Yektaweb