دوره 26، شماره 116 - ( 5-1397 )                   جلد 26 شماره 116 صفحات 110-100 | برگشت به فهرست نسخه ها

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Mansoriyan M, Torabzadeh Khorasani P, Ramezani M. Effect of Fluoxetine on Ovarian and Oviduct Tissue in Female Mature Balb/C Mice. J Adv Med Biomed Res 2018; 26 (116) :100-110
URL: http://journal.zums.ac.ir/article-1-5092-fa.html
منصوریان مهسا، تراب‌زاده خراسانی پروین، رمضانی مینا. ﺑﺮرﺳﻲ اﺛﺮ داروی ﻓﻠﻮﻛﺴﺘﻴﻦ ﺑﺮ روی بافت تخمدان و اوویداکت در موش سوری ماده بالغ C/Balb. Journal of Advances in Medical and Biomedical Research. 1397; 26 (116) :100-110

URL: http://journal.zums.ac.ir/article-1-5092-fa.html

ﺑﺮرﺳﻲ اﺛﺮ داروی ﻓﻠﻮﻛﺴﺘﻴﻦ ﺑﺮ روی بافت تخمدان و اوویداکت در موش سوری ماده بالغ C/Balb
مهسا منصوریان1 ، پروین تراب‌زاده خراسانی*2 ، مینا رمضانی3
1- کارشناس ارشد گروه زیست‌شناسی گرایش تکوین جانوری، دانشگاه آزاد اسلامی واحد کرج، کرج
2- دکترای تخصصی زیست شناسی، استادیار گروه زیست‌شناسی گرایش تکوین جانوری، دانشگاه آزاد اسلامی واحد کرج ، کرج ، p.torabzadeh@gmail.com
3- دکترای تخصصی زیست شناسی ، دانشیار گروه زیست‌شناسی (تکوین جانوری)، دانشگاه آزاد اسلامی واحد تهران مرکزی ، تهران
چکیده:   (161324 مشاهده)

Background and Objective: Use of antidepressants such as fluoxetine, which is widely used worldwide and easily accessible to the public, causes complications such as temporary or permanent infertility. The present study was conducted to investigate the effects of fluoxetine on the ovaries and oviducts of mature female Balb/C mice.
Materials and Methods: In this study after determining the appropriate dose of fluoxetine, it was injected intraperitoneally (IP) for 30 days into 75 adult Balb/C mice with doses of 15 mg/kg (group 1), 20 mg /kg (group 2), 25 mg /kg (group 3), control group (non-injection) and sham (distilled water injection). ANOVA analysis and Duncan test were used to compare the means with significant levels being considered (P<0.05) and (P <0.001).
Results: During macroscopic examination, significant ovary weight decrease was observed in all three doses
(P <0.001) and in microscopic studies, reduction of the small and large diameter, number of graph follicles and corpus luteum were observed (P <0.05 and P <0.001 respectively). Meanwhile, an increase in the number of degenerative follicles and damaged zona pellucidas was significant (P <0.001 and P <0.05), and oviduct diameter was significantly higher than the control group (P <0.05).
Conclusion: It can generally be concluded that fluoxetine has a damaging effect on ovarian and oviduct tissue of mice.

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نوع مطالعه: کارآزمایی بالینی |
دریافت: 1396/12/12 | پذیرش: 1396/12/12 | انتشار: 1396/12/12
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